Atrophy of reward-related striatal structures in fatigued MS patients is independent of physical disability

Conclusions: Fatigued MS patients have a global cortical and subcortical gray-matter atrophy that seems largely related to higher physical disability. However, striatal structures involved in effort-reward functions exhibited smaller volumes in fatigued patients, independently of physical disability and depressive symptoms, supporting the theory of cortico-striatal network impairment in MS fatigue.

http://msj.sagepub.com/cgi/content/abstract/22/6/822?rss=1

Source: Multiple Sclerosis - April 17, 2016 Category: Neurology Authors: Damasceno, A., Damasceno, B. P., Cendes, F. Tags: Original Research Papers Source Type: research