Response to letter regarding article 'Fingolimod effects on left ventricular function in multiple sclerosis
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Racca, V., Di Rienzo, M., Cavarretta, R., Toccafondi, A., Vaini, E., Ferratini, M., Rovaris, M. Tags: Letters to the Editor Source Type: research
Comment on "Fingolimod effects on left ventricular function in multiple sclerosis" Mult Scler 2015
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Bakshi, R., Häring, D. A. Tags: Letters to the Editor Source Type: research
An investigation of the relationship between latitude and multiple sclerosis severity in New Zealand
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Alla, S., Pearson, J. F., Taylor, B. V., Roxburgh, R., Clarke, G., Miller, D. H., Richardson, A., Abernethy, D. A., Willoughby, E., Sabel, C. E., Mason, D. F. Tags: Letters to the Editor Source Type: research
Multiple sclerosis masquerading as Alzheimer-type dementia: Clinical, radiological and pathological findings
Conclusions:
Multiple sclerosis (MS) can cause severe cortical dysfunction and mimic ADem. Cortical demyelination is not well detected by standard imaging modalities and may not be detected on autopsy without myelin immunohistochemistry. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Tobin, W., Popescu, B., Lowe, V., Pirko, I., Parisi, J., Kantarci, K., Fields, J., Bruns, M., Boeve, B., Lucchinetti, C. Tags: Short Reports Source Type: research
Reconsidering outdoor temperature and cognition in multiple sclerosis
Conclusions:
The results of the current work underscore the need to better understand if, when, and how cognitive performance may be influenced by seasonal variables in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Roberg, B. L., Bruce, J. M. Tags: Short Reports Source Type: research
Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study
Conclusion:
Alcohol dependence and smoking were associated with anxiety and depression. Awareness of the effects of adverse health behaviours on mental health in MS might help target counselling and support for those ‘at risk’. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: McKay, K. A., Tremlett, H., Fisk, J. D., Patten, S. B., Fiest, K., Berrigan, L., Marrie, R. A., for the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS) Tags: Original Research Papers Source Type: research
The Chalder Fatigue Questionnaire is a valid and reliable measure of perceived fatigue severity in multiple sclerosis
Conclusions:
The CFQ measuring a composite of physical and mental fatigue severity (i.e. a total score) is a psychometrically sound measure of fatigue severity in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Chilcot, J., Norton, S., Kelly, M. E., Moss-Morris, R. Tags: Original Research Papers Source Type: research
Effect of intramuscular interferon beta-1a on gray matter atrophy in relapsing-remitting multiple sclerosis: A retrospective analysis
Conclusions:
These results suggest that GMF change is more meaningful than WMF as a marker of tissue loss and may be useful to augment whole brain atrophy measurements in MS clinical trials. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Fisher, E., Nakamura, K., Lee, J.-C., You, X., Sperling, B., Rudick, R. Tags: Original Research Papers Source Type: research
Cognitive impairment at diagnosis predicts 10-year multiple sclerosis progression
Conclusion:
Cognitive impairment, with particular involvement of processing speed and memory, predicts disability progression and SP conversion in newly diagnosed RRMS, highlighting the importance of cognitive assessment from the beginning of MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Moccia, M., Lanzillo, R., Palladino, R., Chang, K. C.-M., Costabile, T., Russo, C., De Rosa, A., Carotenuto, A., Sacca, F., Maniscalco, G. T., Brescia Morra, V. Tags: Original Research Papers Source Type: research
Length of optic nerve double inversion recovery hypersignal is associated with retinal axonal loss
Conclusions:
Optic nerve DIR hypersignal length may be a biomarker for retinal axonal loss, easily applicable in routine and research on new anti-inflammatory or neuroprotective drug evaluation. Detection of subclinical ON with 3D-DIR in a non-negligible proportion of MS patients argues in favor of optic nerve imaging in future OCT MS studies, in order to achieve a better understanding of retinal axonal loss in non-ON eyes. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Hadhoum, N., Hodel, J., Defoort-Dhellemmes, S., Duhamel, A., Drumez, E., Zephir, H., Pruvo, J., Leclerc, X., Vermersch, P., Outteryck, O. Tags: Original Research Papers Source Type: research
Retinal ganglion cell layer thinning within one month of presentation for optic neuritis
Conclusion:
GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1–2 months of onset, prior to pRNFL thinning. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Kupersmith, M. J., Garvin, M. K., Wang, J.-K., Durbin, M., Kardon, R. Tags: Original Research Papers Source Type: research
Regional hippocampal involvement and cognitive impairment in pediatric multiple sclerosis
Conclusions:
Hippocampal subregions have different vulnerability to damage in pediatric MS. Regional rather than global hippocampal involvement contributes to global cognitive impairment as well as to deficits of selected cognitive tests. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Rocca, M. A., Morelli, M. E., Amato, M. P., Moiola, L., Ghezzi, A., Veggiotti, P., Capra, R., Pagani, E., Portaccio, E., Fiorino, A., Pippolo, L., Pera, M. C., Comi, G., Falini, A., Filippi, M. Tags: Original Research Papers Source Type: research
Diffusion tensor magnetic resonance imaging in very early onset pediatric multiple sclerosis
Conclusions:
In very young pediatric MS patients, DT MRI abnormalities affect brain WM tracts differentially, and are only partially correlated with focal WM lesions. Impaired maturation of WM tracts with age may be an additional factor contributing to these findings. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Rocca, M., Sonkin, M., Copetti, M., Pagani, E., Arnold, D., Narayanan, S., Sled, J., Banwell, B., Filippi, M. Tags: Original Research Papers Source Type: research
Multi-parametric structural magnetic resonance imaging in relation to cognitive dysfunction in long-standing multiple sclerosis
Conclusion:
From all imaging markers, deep grey matter atrophy and diffuse white matter damage emerged as the strongest predictors for cognitive dysfunction in long-standing multiple sclerosis. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Daams, M., Steenwijk, M. D., Schoonheim, M. M., Wattjes, M. P., Balk, L. J., Tewarie, P. K., Killestein, J., Uitdehaag, B. M., Geurts, J. J., Barkhof, F. Tags: Original Research Papers Source Type: research
Contribution of the cerebellum to cognitive performance in children and adolescents with multiple sclerosis
Conclusion:
Smaller cerebellar posterior lobe volume, a known region for cognitive processing, and increased lesion burden in the posterior fossa adversely impact cognitive function, an important functional consequence of MS onset during childhood. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 23, 2016 Category: Neurology Authors: Weier, K., Till, C., Fonov, V., Yeh, E. A., Arnold, D. L., Banwell, B., Collins, D. L. Tags: Original Research Papers Source Type: research
