Vitamin D in multiple sclerosis patients: Not the same risk for everybody
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Rito, Y., Flores, J., Fernandez Aguilar, A., Escalante Membrillo, C., Gutierrez Lanz, E., Barboza, M. A., Rivas Alonso, V., Trevino Frenk, I., Corona Vazquez, T. Tags: Letters to the Editor Source Type: research
Aquaporin-4: A novel diagnostic biomarker for seronegative neuromyelitis optica
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Zajda, M., Kazmierczak, B., Zakrzewska-Pniewska, B. Tags: Letters to the Editor Source Type: research
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis
Conclusions:
Lymphomatoid papulosis is a benign subtype of cutaneous T-cell lymphoma, but up to 20% of cases can transform to a malignant course. Patients on fingolimod and physicians caring for them should be mindful of the need to monitor the skin. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Samaraweera, A. P., Cohen, S. N., Akay, E. M., Evangelou, N. Tags: Case Report Source Type: research
Baseline clinical status as a predictor of methylprednisolone response in multiple sclerosis relapses
Conclusions:
Clinical baseline status prior to MS relapse is a predictor of response to methylprednisolone treatment. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Ramo-Tello, C., Tintore, M., Rovira, A., Ramio-Torrenta, L., Brieva, L., Saiz, A., Cano, A., Carmona, O., Hervas, J. V., Grau-Lopez, L. Tags: Short Reports Source Type: research
Progressive multiple sclerosis exhibits decreasing glutamate and glutamine over two years
Conclusions:
The high rates of change of both glutamate and glutamine over two years suggest they are promising new biomarkers of MS disease progression. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: MacMillan, E., Tam, R., Zhao, Y., Vavasour, I., Li, D., Oger, J., Freedman, M., Kolind, S., Traboulsee, A. Tags: Short Reports Source Type: research
Level of education and multiple sclerosis risk after adjustment for known risk factors: The EnvIMS study
Conclusion:
These findings suggest that factors related to lower socioeconomic status other than established risk factors are associated with MS risk. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Bjornevik, K., Riise, T., Cortese, M., Holmoy, T., Kampman, M. T., Magalhaes, S., Myhr, K.-M., Wolfson, C., Pugliatti, M. Tags: Original Research Papers Source Type: research
Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - a randomized controlled trial
Conclusions:
The findings indicate that the step training programme is feasible, safe and effective in improving stepping, standing balance, coordination and functional performance in people with MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Hoang, P., Schoene, D., Gandevia, S., Smith, S., Lord, S. R. Tags: Original Research Papers Source Type: research
Comparative analysis of first-year fingolimod and natalizumab drug discontinuation among Swedish patients with multiple sclerosis
Conclusion:
FGL and NTZ were both well tolerated, but FGL less so than NTZ, especially in patients switching to FGL from NTZ. Group differences were not explained by differences in recorded baseline characteristics. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Frisell, T., Forsberg, L., Nordin, N., Kiesel, C., Alfredsson, L., Askling, J., Hillert, J., Olsson, T., Piehl, F. Tags: Original Research Papers Source Type: research
Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration
Conclusion:
"Normal appearing" cerebellar white matter can be damaged in a very early stage of RRMS. DTI seems to be a sensitive tool for detecting this hidden cerebellar damage. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Deppe, M., Tabelow, K., Krämer, J., Tenberge, J.-G., Schiffler, P., Bittner, S., Schwindt, W., Zipp, F., Wiendl, H., Meuth, S. G. Tags: Original Research Papers Source Type: research
No evidence of disease activity in multiple sclerosis: Implications on cognition and brain atrophy
Conclusions:
NEDA status was achieved in a small proportion of our cohort, and did not preclude cognitive deterioration. Absence of MRI activity and especially of new/enlarging T2 lesions was associated with less cortical and subcortical GM atrophy. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Damasceno, A., Damasceno, B. P., Cendes, F. Tags: Original Research Papers Source Type: research
Diffusivity signatures characterize trigeminal neuralgia associated with multiple sclerosis
Conclusions:
The study demonstrates objective differences in CN V microstrucuture in TN and MS-TN using non-invasive neuroimaging. This represents a significant improvement in the methods currently available to study pain in MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Chen, D. Q., DeSouza, D. D., Hayes, D. J., Davis, K. D., OConnor, P., Hodaie, M. Tags: Original Research Papers Source Type: research
Corticospinal tract integrity measured using transcranial magnetic stimulation and magnetic resonance imaging in neuromyelitis optica and multiple sclerosis
Conclusion:
Corticospinal pathway damage in individuals with NMO was evident by reduced recruitment curve slope and lower myelin water fraction. These specific measures of corticospinal function and structure may be used to obtain a better understanding and monitor brain injury caused by inflammatory central nervous system disorders. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Manogaran, P., Vavasour, I., Borich, M., Kolind, S. H., Lange, A. P., Rauscher, A., Boyd, L., Li, D. K., Traboulsee, A. Tags: Original Research Papers Source Type: research
Cognitive reserve moderates the impact of subcortical gray matter atrophy on neuropsychological status in multiple sclerosis
Conclusions:
SCGM atrophy occurs in normal controls, but significantly more so in MS. While CPS did not change in normal controls, low cognitive reserve was associated with CPS decline in MS. High cognitive reserve protect MS patients from cognitive decline related to SCGM atrophy. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Modica, C. M., Bergsland, N., Dwyer, M. G., Ramasamy, D. P., Carl, E., Zivadinov, R., Benedict, R. H. Tags: Original Research Papers Source Type: research
Temporal lobe cortical pathology and inhibitory GABA interneuron cell loss are associated with seizures in multiple sclerosis
Conclusion:
We confirm that seizure frequency rises in MS. Type I GMLs in the temporal lobe underlie a loss of inhibitory interneurons in cortical layers IV and VI and these changes could together with concurrent infection enhance susceptibility to seizures. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Nicholas, R., Magliozzi, R., Campbell, G., Mahad, D., Reynolds, R. Tags: Original Research Papers Source Type: research
HLA associations in South Asian multiple sclerosis
Conclusion:
Our study confirms that the risk effects attributable to the HLA- DRB1*15:01and DRB1*03 alleles seen in Europeans are also seen in Indians. The absence of any evidence of association with DQB1 alleles reflects the lower linkage disequilibrium between DQB1 alleles and DRB1 risk alleles present in this population, and illustrates the potential value of fine mapping signals of association in different ethnic groups. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Pandit, L., Malli, C., Singhal, B., Wason, J., Malik, O., Sawcer, S., Ban, M., DCunha, A., Mustafa, S. Tags: Original Research Papers Source Type: research
