Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis
Conclusion:
MOG-ON and AQP4-ON are more commonly bilateral and longitudinally extensive. MOG-ON tends to involve the anterior optic pathway, whereas AQP4-ON the posterior optic pathway. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Ramanathan, S., Prelog, K., Barnes, E. H., Tantsis, E. M., Reddel, S. W., Henderson, A. P., Vucic, S., Gorman, M. P., Benson, L. A., Alper, G., Riney, C. J., Barnett, M., Parratt, J. D., Hardy, T. A., Leventer, R. J., Merheb, V., Nosadini, M., Fung, V. S. Tags: Original Research Papers Source Type: research
Population attributable fractions and joint effects of key risk factors for multiple sclerosis
Conclusions:
A high proportion of FCD onset can be explained by the currently known risk factors, with HLA-DR15, ever smoking and low cumulative sun exposure explaining most. We identified a significant interaction between HLA-DR15 and history of IM in predicting an FCD of CNS demyelination, which together with previous observations suggests that this is a true interaction. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: van der Mei, I., Lucas, R., Taylor, B., Valery, P., Dwyer, T., Kilpatrick, T., Pender, M., Williams, D., Chapman, C., Otahal, P., Ponsonby, A.-L. Tags: Original Research Papers Source Type: research
Metabolomics in multiple sclerosis
Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system with inflammatory and degenerative components. The cause of MS remains unknown although genetic and environmental factors appear to play a role in its etiopathogenesis. Metabolomics is a new "omics" technology that aims at measuring small molecules in various biological matrices and can provide information that is not readily obtained from genomics, transcriptomics, or proteomics. Currently, several different analytical platforms exist for metabolomics, and both untargeted and targeted approaches are being employed. Methods of analysi...
Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: Bhargava, P., Calabresi, P. A. Tags: Topical Review Source Type: research
PACTRIMS abstracts
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Tags: Abstracts Source Type: research
PML in DMF-treated patients with normal lymphocytes: Worried well or well to be worried?
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Carruthers, R., Healy, B. Tags: Letters to the Editor Source Type: research
Are Lebers mitochondial DNA mutations associated with aquaporin-4 autoimmunity?
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Dujmovic, I., Jancic, J., Dobricic, V., Jankovic, M., Novakovic, I., Comabella, M., Drulovic, J. Tags: Letters to the Editor Source Type: research
Assessing PML risk under immunotherapy: if all you have is a hammer, everything looks like a nail
Recently, three progressive multifocal leukoencephalopathy (PML) cases have been reported in multiple sclerosis (MS) patients, two treated with fingolimod (Gilenya, Novartis), the third with dimethyl fumarate (Tecfidera, Biogen). Because our immunotherapeutic arsenal in MS and other diseases is increasing, and because PML is a very serious health risk, it is of interest to the clinical community to show how we can assess this risk in a statistically sound way. The null-hypothesis for this analysis was that there is no elevated risk for PML in patients treated with one of these recent drugs, compared to the incidence in the...
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Van Schependom, J., Gielen, J., Laton, J., Nagels, G. Tags: Short Reports Source Type: research
Viral exposures and MS outcome in a prospective cohort of children with acquired demyelination
Epstein–Barr virus (EBV) infection is associated with increased multiple sclerosis (MS) risk. Recently, cytomegalovirus (CMV) infection has been proposed as a protective factor against MS development. We determined EBV, herpes simplex virus, varicella-zoster virus and CMV seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ADS). Remote EBV infection was more common in children with MS than those with monophasic ADS while CMV infection was more common in children with monophasic ADS. Children displaying evidence of remote EBV without CMV infection were at highest risk of subseq...
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Makhani, N., Banwell, B., Tellier, R., Yea, C., McGovern, S., OMahony, J., Ahorro, J. M., Arnold, D., Sadovnick, A. D., Marrie, R. A., Bar-Or, A., on behalf of the Canadian Pediatric Demyelinating Disease Network Tags: Short Reports Source Type: research
The effects of robot-assisted gait training in progressive multiple sclerosis: A randomized controlled trial
Conclusion:
RAGT is a treatment option in progressive MS patients with severe gait impairments to induce short-lasting effects on mobility and QoL. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Straudi, S., Fanciullacci, C., Martinuzzi, C., Pavarelli, C., Rossi, B., Chisari, C., Basaglia, N. Tags: Original Research Papers Source Type: research
Outer retinal changes following acute optic neuritis
Conclusions:
Following AON, dynamic changes occur in the deep retinal layers, which are proportional to GCIP thinning. These novel findings help further our understanding of the biological and/or anatomical sequelae resulting from AON. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Al-Louzi, O. A., Bhargava, P., Newsome, S. D., Balcer, L. J., Frohman, E. M., Crainiceanu, C., Calabresi, P. A., Saidha, S. Tags: Original Research Papers Source Type: research
Cognitive and patient-reported outcomes in adults with pediatric-onset multiple sclerosis
Conclusions:
Younger age of onset was associated with more impairment in information-processing speed in adults with POMS compared to AOMS, and remained significant when controlling for disease duration in age-normed analysis. The two groups were similar in terms of patient-reported outcomes, suggesting similar qualitative experiences of MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Baruch, N. F., ODonnell, E. H., Glanz, B. I., Benedict, R. H., Musallam, A. J., Healy, B. C., Rintell, D., Chitnis, T. Tags: Original Research Papers Source Type: research
Psychiatric co-morbidity in multiple sclerosis: The risk of depression and anxiety before and after MS diagnosis
Conclusion:
During both the pre- diagnostic and post-diagnostic period, MS patient have increased risk of depression and anxiety diagnoses and redemption of antidepressant and anxiolytic prescriptions, compared to the background population. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Hoang, H., Laursen, B., Stenager, E. N., Stenager, E. Tags: Original Research Papers Source Type: research
Combined analysis of global and compartmental brain volume changes in early multiple sclerosis in clinical practice
Conclusions:
PBVC is the most sensitive marker of progressing atrophy and a higher PBVC was generally associated with more active disease; however, it did not serve to predict the course of MS on an individual basis, in this study. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Pichler, A., Khalil, M., Langkammer, C., Pinter, D., Bachmaier, G., Ropele, S., Fuchs, S., Enzinger, C., Fazekas, F. Tags: Original Research Papers Source Type: research
Comparative analysis of treatment outcomes in patients with neuromyelitis optica spectrum disorder using multifaceted endpoints
Conclusions:
The present study showed that reductions in the risks of relapse and severe relapse differed among patients who were initially treated with azathioprine, MMF, and rituximab. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Jeong, I. H., Park, B., Kim, S.-H., Hyun, J.-W., Joo, J., Kim, H. J. Tags: Original Research Papers Source Type: research
Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T
Background:
The clinical course of multiple sclerosis (MS) is mainly attributable to cervical and upper thoracic spinal cord dysfunction. High-resolution, 7T anatomical imaging of the cervical spinal cord is presented. Image contrast between gray/white matter and lesions surpasses conventional, clinical T1- and T2-weighted sequences at lower field strengths.
Objective:
To study the spinal cord of healthy controls and patients with MS using magnetic resonance imaging at 7T.
Methods:
Axial (C2–C5) T1- and T2*-weighted and sagittal T2*-/spin-density-weighted images were acquired at 7T in 13 healthy volunteers (age 22&...
Source: Multiple Sclerosis - March 7, 2016 Category: Neurology Authors: Dula, A. N., Pawate, S., Dortch, R. D., Barry, R. L., George-Durrett, K. M., Lyttle, B. D., Dethrage, L. M., Gore, J. C., Smith, S. A. Tags: Original Research Papers Source Type: research
