Population attributable fractions and joint effects of key risk factors for multiple sclerosis

Conclusions:
A high proportion of FCD onset can be explained by the currently known risk factors, with HLA-DR15, ever smoking and low cumulative sun exposure explaining most. We identified a significant interaction between HLA-DR15 and history of IM in predicting an FCD of CNS demyelination, which together with previous observations suggests that this is a true interaction.

Source: Multiple Sclerosis - March 17, 2016 Category: Neurology Authors: van der Mei, I., Lucas, R., Taylor, B., Valery, P., Dwyer, T., Kilpatrick, T., Pender, M., Williams, D., Chapman, C., Otahal, P., Ponsonby, A.-L. Tags: Original Research Papers Source Type: research