Clinical trials for pediatric MS should be prioritized to test only one or two of the most promising agents - NO
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Francisco, C., Graves, J., Waubant, E. Tags: Controversies in Multiple Sclerosis Source Type: research
Clinical trials for pediatric MS should be prioritized to test only one or two of the most promising agents - YES
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Banwell, B. Tags: Controversies in Multiple Sclerosis Source Type: research
Observational data: Understanding the real MS world
Randomised clinical trials are the primary source of evidence, guiding the use of disease-modifying drugs in multiple sclerosis. However, the spectrum of questions that can be answered in the trial setting is relatively narrow. ‘Real-world’ observational data analysis has always been the major source of evidence for epidemiology, aetiology, outcomes and prognostics, but is now also increasingly used to study treatment effectiveness. While analyses of observational cohorts typically offer superior power, generalisability and duration of follow-up relative to prospective randomised trials, they are also subject t...
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Kalincik, T., Butzkueven, H. Tags: Topical Review Source Type: research
Biotin in progressive multiple sclerosis: A new lead?
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - November 3, 2016 Category: Neurology Authors: Chataway, J. Tags: Editorial Source Type: research
William A. Sibley (1925-2015): Clinical researcher, diagnostician, champion of interdisciplinary neuroscience
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Stuart, D. G., Gruener, R. P. Tags: Letters Source Type: research
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Matoula, T., Nikolaou, V., Marinos, L., Katsavos, S., Nasis, G., Economidi, A., Karampidou, K., Stratigos, A., Antoniou, C. Tags: Letters Source Type: research
Lymphomatoid papulosis and fingolimod--A new connection?
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Cohen, V., Saber, M., Provost, N., Friedmann, D. Tags: Letters Source Type: research
Reversible cerebral vasoconstriction syndrome associated with interferon beta-1a use for multiple sclerosis
We describe the case of a 20-year-old female who developed acute onset severe headache and was found to have subarachnoid hemorrhage 2 months after initiating Rebif (Interferon beta-1a) for multiple sclerosis (MS). Cerebral angiography showed multiple areas of distal stenosis and dilatation with radiographic resolution 1 month later.
Results/conclusions:
This is the first case report of RCVS in an MS patient treated with Rebif. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Strohm, T., Chaudhry, B., Willis, M. A., Shook, S. Tags: Case Report Source Type: research
Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis
Conclusions:
Findings inform the development of targeted evidence-based enrichment programs aiming to bolster reserve against memory decline. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Sumowski, J. F., Rocca, M. A., Leavitt, V. M., Riccitelli, G., Meani, A., Comi, G., Filippi, M. Tags: Short Reports Source Type: research
Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Jeong, I. H., Choi, J. Y., Kim, S.-H., Hyun, J.-W., Joung, A., Lee, J., Kim, H. J. Tags: Short Reports Source Type: research
The contribution of depressive symptoms to slowness of information processing in relapsing remitting multiple sclerosis
Conclusion:
The contribution of DS to slowness depends on the level of cognitive demands. However, its impact on MS is more deleterious than on the general population. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Lubrini, G., Rios Lago, M., Perianez, J. A., Tallon Barranco, A., De Dios, C., Fernandez-Fourier, M., Diez Tejedor, E., Frank Garcia, A. Tags: Original Research Papers Source Type: research
Validity of visual perceptive computing for static posturography in patients with multiple sclerosis
Conclusion:
Postural control can be reliably assessed by VPC-based static posturography in patients with MS. Abnormal postural control seems to predominantly reflect involvement of cerebellar circuits with impact on gait and walking disability. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Behrens, J. R., Mertens, S., Krüger, T., Grobelny, A., Otte, K., Mansow-Model, S., Gusho, E., Paul, F., Brandt, A. U., Schmitz-Hübsch, T. Tags: Original Research Papers Source Type: research
Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone
Conclusion:
Increased CSF levels of sTREM-2, a new marker of microglial activation, in MS and normalization upon treatment with either natalizumab or mitoxantrone support a role for microglial activation in active MS. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Öhrfelt, A., Axelsson, M., Malmeström, C., Novakova, L., Heslegrave, A., Blennow, K., Lycke, J., Zetterberg, H. Tags: Original Research Papers Source Type: research
Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis
Conclusions:
Joint clinical evaluation of T2-FLAIR and FLAIR* images modestly improves diagnostic accuracy for MS and does not require counting lesions with central veins. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: George, I. C., Sati, P., Absinta, M., Cortese, I. C., Sweeney, E. M., Shea, C. D., Reich, D. S. Tags: Original Research Papers Source Type: research
Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types
Conclusion:
Using multi-scale spectral analysis, it may be possible for standard MRI to evaluate myelin integrity in MS lesions. This can be critical for monitoring disease activity and assessing remyelination therapies for MS patients. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 13, 2016 Category: Neurology Authors: Zhang, Y., Jonkman, L., Klauser, A., Barkhof, F., Yong, V. W., Metz, L. M., Geurts, J. J. Tags: Original Research Papers Source Type: research
