Cardiopulmonary fitness is related to disease severity in multiple sclerosis
Conclusion:
There was a significant association between disease severity and cardiopulmonary fitness. The close relation between cardiopulmonary fitness and chronic conditions associated with physical inactivity, suggest a progressive increase in risk of secondary health conditions in pwMS (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Heine, M., Wens, I., Langeskov-Christensen, M., Verschuren, O., Eijnde, B. O., Kwakkel, G., Dalgas, U. Tags: Original Research Papers Source Type: research
Neuroenhancement through cognitive training and anodal tDCS in multiple sclerosis
Conclusions:
These results indicate that a-tDCS on the DLPFC during cognitive training fosters improvements in attention and executive function in MS patients and shortens treatment duration. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Mattioli, F., Bellomi, F., Stampatori, C., Capra, R., Miniussi, C. Tags: Original Research Papers Source Type: research
Prolonged-release fampridine and walking and balance in MS: randomised controlled MOBILE trial
Conclusions:
PR-fampridine therapy resulted in early and sustained improvements in broad measures of walking and balance over six months. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Hupperts, R., Lycke, J., Short, C., Gasperini, C., McNeill, M., Medori, R., Tofil-Kaluza, A., Hovenden, M., Mehta, L. R., Elkins, J. Tags: Original Research Papers Source Type: research
Fingolimod effects on left ventricular function in multiple sclerosis
Conclusion:
Fingolimod significantly reduces left ventricular systolic function in MS patients. This effect has no clinical consequences in subjects without previous cardiac disorders, but suggests that more caution is required in patients with current or previous heart failure. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Racca, V., Di Rienzo, M., Cavarretta, R., Toccafondi, A., Vaini, E., Ferratini, M., Rovaris, M. Tags: Original Research Papers Source Type: research
Menarche increases relapse risk in pediatric multiple sclerosis
Conclusion:
Pubertal status may influence MS course at least in female patients. Understanding how puberty influences MS clinical features may offer new insights into important factors regulating disease processes. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Lulu, S., Graves, J., Waubant, E. Tags: Original Research Papers Source Type: research
Treatment of acute relapses in neuromyelitis optica: Steroids alone versus steroids plus plasma exchange
Conclusions:
PLEX+IVMP are more likely to improve EDSS after NMO relapses compared to IVMP alone, especially in patients taking preventive medications. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Abboud, H., Petrak, A., Mealy, M., Sasidharan, S., Siddique, L., Levy, M. Tags: Original Research Papers Source Type: research
Clinical and MRI phenotype of children with MOG antibodies
Conclusion:
MOG antibodies are found across a variety of pediatric demyelinating syndromes having some distinct clinical and MRI features. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Fernandez-Carbonell, C., Vargas-Lowy, D., Musallam, A., Healy, B., McLaughlin, K., Wucherpfennig, K. W., Chitnis, T. Tags: Original Research Papers Source Type: research
Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica
Conclusion:
Although NMO and MS neutrophils display an activated phenotype in comparison with HC, NMO neutrophils show a compromised functionality when compared with MS patients. These results suggest a distinct functional profile of neutrophils in MS and NMO. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Hertwig, L., Pache, F., Romero-Suarez, S., Stürner, K. H., Borisow, N., Behrens, J., Bellmann-Strobl, J., Seeger, B., Asselborn, N., Ruprecht, K., Millward, J. M., Infante-Duarte, C., Paul, F. Tags: Original Research Papers Source Type: research
Characteristics of lesional and extra-lesional cortical grey matter in relapsing-remitting and secondary progressive multiple sclerosis: A magnetisation transfer and diffusion tensor imaging study
Conclusion:
Magnetic resonance abnormalities in lesional and extra-lesional cortical grey matter are greater in SPMS than RRMS. Changes in extra-lesional compared with lesional cortical grey matter are more consistently associated with disability. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Yaldizli, O., Pardini, M., Sethi, V., Muhlert, N., Liu, Z., Tozer, D. J., Samson, R. S., Wheeler-Kingshott, C. A., Yousry, T. A., Miller, D. H., Chard, D. T. Tags: Original Research Papers Source Type: research
Linking synaptopathy and gray matter damage in multiple sclerosis
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Musella, A., Mandolesi, G., Mori, F., Gentile, A., Centonze, D. Tags: Personal Viewpoint Source Type: research
Modeling the course and outcomes of MS is statistical twaddle--Commentary
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Hutchinson, M. Tags: Controversies in Multiple Sclerosis Source Type: research
Modeling the course and outcomes of MS is statistical twaddle--No
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Bergamaschi, R., Montomoli, C. Tags: Controversies in Multiple Sclerosis Source Type: research
Modeling the course and outcomes of multiple sclerosis is statistical twaddle--Yes
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Taylor, B. V. Tags: Controversies in Multiple Sclerosis Source Type: research
Implications of dietary salt intake for multiple sclerosis pathogenesis
In recent years it has become increasingly clear that, alongside genetic risk factors, environmental factors strongly influence the incidence and severity of multiple sclerosis (MS). Based on observations from epidemiological studies, the potential contribution of dietary habits has lately been a matter of debate. Recently it was shown that high salt conditions promote pathogenic T-cell responses and aggravate autoimmunity in an animal model of MS, suggesting that high dietary salt intake might promote central nervous system (CNS) autoimmunity. However, so far, not much is known about the influence of dietary salt intake o...
Source: Multiple Sclerosis - February 1, 2016 Category: Neurology Authors: Hucke, S., Wiendl, H., Klotz, L. Tags: Topical Review Source Type: research
Antibodies to myelin oligodendrocyte glycoprotein are uncommon in Japanese opticospinal multiple sclerosis
(Source: Multiple Sclerosis)
Source: Multiple Sclerosis - December 18, 2015 Category: Neurology Authors: Ramanathan, S., Sato, S., Matsushita, T., Masaki, K., Yamasaki, R., Dale, R. C., Kira, J.-i., Brilot, F. Tags: Letters to the Editor Source Type: research
