Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study

Conclusions:
AQP4-IgG1 antibodies are present in the sera years before the first NMO attack in patients with SLE; elevation of anti-AQP4 is part of a polyclonal B cell response during NMO relapses; in spite of multiple autoantibodies in the serum, MOG antibodies were not present; Th1 responses accompany autoantibody responses in NMO/SLE.

Source: Multiple Sclerosis - July 25, 2016 Category: Neurology Authors: Kovacs, K. T., Kalluri, S. R., Boza-Serrano, A., Deierborg, T., Csepany, T., Simo, M., Rokusz, L., Miseta, A., Alcaraz, N., Czirjak, L., Berki, T., Molnar, T., Hemmer, B., Illes, Z. Tags: Original Research Papers Source Type: research