Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients

Conclusions:
DMF shifts the immunophenotypes of circulating T cells, causing a reduction of memory cells and a relative expansion of naïve cells, regardless of the absolute lymphocyte count. This may represent one mechanism of action of the drug. Lymphopenic patients had a disproportionate loss of CD8+ T-cells, which may affect their immunocompetence.

Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Longbrake, E. E., Ramsbottom, M. J., Cantoni, C., Ghezzi, L., Cross, A. H., Piccio, L. Tags: Original Research Papers Source Type: research