Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome

Conclusion:
Infiltration of activated macrophages evidenced by USPIO enhancement, is present at the onset of multiple sclerosis and is associated with higher and persistent local loss of tissue structure. Macrophage infiltration affects more tissue structure while tissue recovery during the following year has a similar pattern for USPIO and Gd-enhanced lesions, leading to relative higher persistent local loss of tissue structure in lesions showing USPIO enhancement at baseline.

Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Maarouf, A., Ferre, J.-C., Zaaraoui, W., Le Troter, A., Bannier, E., Berry, I., Guye, M., Pierot, L., Barillot, C., Pelletier, J., Tourbah, A., Edan, G., Audoin, B., Ranjeva, J.-P. Tags: Original Research Papers Source Type: research