Effect of fingolimod on cardiac autonomic regulation in patients with multiple sclerosis

Conclusions:
After an initial increase in parasympathetic regulation, continuous fingolimod dosing shifts cardiac autonomic regulation towards sympathetic predominance, especially in men. Careful follow-up of fingolimod-treated relapsing–remitting multiple sclerosis patients is warranted as sympathetic predominance associates generally with impaired outcome.
ClinicalTrials.cov: NCT01704183

Source: Multiple Sclerosis - July 5, 2016 Category: Neurology Authors: Simula, S., Laitinen, T., Laitinen, T. M., Tarkiainen, T., Hartikainen, P., Hartikainen, J. E. Tags: Original Research Papers Source Type: research