Prenatal tolbutamide treatment alters plasma glucose and insulin concentrations and negatively affects the postnatal performance of chickens
To examine the relationship of insulin and glucose, broiler embryos were subjected to acute or prolonged hypoglycemia during the late embryonic phase by respectively injecting once (at embryonic day (ED) 16 or 17), or on three consecutive days (ED 16, 17 and 18) with tolbutamide (80 μg/g embryo weight), a substance that stimulates insulin secretion from the pancreas. After one tolbutamide injection, a prolonged (32 h) decrease of plasma glucose and a profound acute increase in plasma insulin were observed. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 27, 2015 Category: Endocrinology Authors: L. Franssens, J. Lesuisse, Y. Wang, B. De Ketelaere, E. Willems, A. Koppenol, X. Guo, J. Buyse, E. Decuypere, N. Everaert Source Type: research
Expression profiles of relaxin family peptides and their receptors indicate their influence on spermatogenesis in the domestic cat ()
Disturbed spermatogenesis is a common problem in felines. Studying spermatogenesis in the domestic cat can improve understanding of the biological background and help to counteract fertility problems in other feline species. Here, we analyzed three relaxin family peptides (relaxin, relaxin-3 and INSL3) and their receptors (RXFP1, RXFP2 and RXFP3) as potential spermatogenic factors involving their expression in the testis at different stages of its development. It may be concluded from its stage-dependent expression that relaxin together with RXFP1 appears to be involved in the first stage of spermatogenesis, whereas relaxi...
Source: Domestic Animal Endocrinology - January 27, 2015 Category: Endocrinology Authors: B.C. Braun, K. Müller, K. Jewgenow Source Type: research
Effects of season, age, sex, and housing on salivary cortisol concentrations in horses
In this study, we have analyzed salivary cortisol concentration for more than 6 mo in horses (n = 94) differing in age, sex, reproductive state, and housing. Salivary cortisol followed a diurnal rhythm with the highest concentrations in the morning and a decrease throughout the day (P < 0.001). (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 21, 2015 Category: Endocrinology Authors: J. Aurich, M. Wulf, N. Ille, R. Erber, M. von Lewinski, R. Palme, C. Aurich Source Type: research
Effects of season, age, sex and housing on salivary cortisol concentrations in horses
In this study, we have analysed salivary cortisol concentration over 6 mo in horses (n = 94) differing in age, sex, reproductive state and housing. Salivary cortisol followed a diurnal rhythm with highest concentrations in the morning and a decrease throughout the day (P < 0.001). (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 21, 2015 Category: Endocrinology Authors: J. Aurich, M. Wulf, N. Ille, R. Erber, M. von Lewinski, R. Palme, C. Aurich Source Type: research
Molecular characterization and hormonal regulation of tissue inhibitor of metalloproteinase 1 in goat ovarian granulosa cells
In this study, the full-length complementary DNA of goat (Capra hircus) Timp1 was cloned from adult goat ovary for the first time to better understand the regulatory role of TIMP1. The putative TIMP1 protein shared a high amino acid sequence identity with other species. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 19, 2015 Category: Endocrinology Authors: J.Y. Peng, P. Han, H.Y. Xin, S.Y. Ji, K.X. Gao, X.P. An, B.Y. Cao Source Type: research
Undernutrition regulates the expression of a novel splice variant of myostatin and insulin-like growth factor 1 in ovine skeletal muscle
Undernutrition suppresses the growth of skeletal muscles and alters the expression of insulin-like growth factor 1 (IGF1), a key mitogen, and myostatin, a potent inhibitor of myogenesis. These changes can explain, at least in part, the reduced growth of skeletal muscles in underfed lambs. We have recently identified a myostatin splice variant (MSV) that binds to and antagonizes the canonical signaling of myostatin. In the present study, we hypothesized that the expression of MSV would be reduced in conjunction with myostatin and IGF1 in response to underfeeding in skeletal muscles of sheep. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 19, 2015 Category: Endocrinology Authors: F. Jeanplong, C.C. Osepchook, S.J. Falconer, H.K. Smith, J.J. Bass, C.D. McMahon, J.M. Oldham Source Type: research
Molecular characterization and hormonal regulation of tissue inhibitor of metalloproteinase 1 (TIMP1) in goat ovarian granulosa cells
In this study, the full-length cDNA of goat (Capra hircus) Timp1 was cloned from adult goat ovary for the first time to better understand the regulatory role of TIMP1. The putative TIMP1 protein shared a high amino acid sequence identity with other species. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 19, 2015 Category: Endocrinology Authors: J.Y. Peng, P. Han, H.Y. Xin, S.Y. Ji, K.X. Gao, X.P. An, B.Y. Cao Source Type: research
Undernutrition regulates the expression of a novel splice variant of myostatin and IGF1 in ovine skeletal muscle
Undernutrition suppresses the growth of skeletal muscles and alters the expression of insulin-like growth factor 1 (IGF1), a key mitogen, and myostatin, a potent inhibitor of myogenesis. These changes can explain, at least in part, the reduced growth of skeletal muscles in underfed lambs. We have recently identified a myostatin splice variant (MSV) that binds to and antagonizes the canonical signalling of myostatin. In the current study, we hypothesized that expression of MSV would be reduced in conjunction with myostatin and IGF1 in response to underfeeding in skeletal muscles of sheep. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - January 19, 2015 Category: Endocrinology Authors: F. Jeanplong, C.C. Osepchook, S.J. Falconer, H.K. Smith, J.J. Bass, C.D. McMahon, J.M. Oldham Source Type: research
Genetic variants in glucocorticoid and mineralocorticoid receptors are associated with concentrations of plasma cortisol, muscle glycogen content, and meat quality traits in male Nellore cattle
The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are key components in the regulation of the hypothalamic-pituitary-adrenal neuroendocrine axis and coordinate the physiological response to stress agents to reestablish homeostasis. Genetic variations of GR (NR3C1) and MR (NR3C2) genes could explain the alterations in animals to adapt to challenges, and therefore, their influence on production traits. The present study aimed to identify single-nucleotide polymorphisms (SNPs) in the bovine NR3C1 and NR3C2 genes and explore their associations to relevant traits of beef cattle production. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - December 20, 2014 Category: Endocrinology Authors: M.D. Poleti, R.H. DeRijk, A.F. Rosa, C.T. Moncau, P.S. Oliveira, L.L. Coutinho, J.P. Eler, J.C.C. Balieiro Source Type: research
Genetic variants in gluco- and mineralocorticoid receptors are associated with concentrations of plasma cortisol, muscle glycogen content and meat quality traits in male Nellore cattle
The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are key components in the regulation of the hypothalamic-pituitary-adrenal (HPA) neuroendocrine axis and coordinate the physiological response to stress agents to re-establish homeostasis. Genetic variations of GR (NR3C1) and MR (NR3C2) genes could explain the alterations in animals to adapt to challenges and therefore their influence on production traits. The present study aimed to identify single nucleotide polymorphisms (SNPs) in the bovine NR3C1 and NR3C2 genes and explore their associations to relevant traits of beef cattle production. (Source: Domes...
Source: Domestic Animal Endocrinology - December 20, 2014 Category: Endocrinology Authors: M.D. Poleti, R.H. DeRijk, A.F. Rosa, C.T. Moncau, P.S. Oliveira, L.L. Coutinho, J.P. Eler, J.C.C. Balieiro Source Type: research
Pharmacology of the glucagon-like peptide-1 analog exenatide extended-release in healthy cats
Exenatide extended-release (ER) is a microencapsulated formulation of the glucagon-like peptide 1-receptor agonist exenatide. It has a protracted pharmacokinetic profile that allows a once-weekly injection with comparable efficacy to insulin with an improved safety profile in type II diabetic people. Here, we studied the pharmacology of exenatide ER in 6 healthy cats. A single subcutaneous injection of exenatide ER (0.13 mg/kg) was administered on day 0. Exenatide concentrations were measured for 12 wk. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - December 19, 2014 Category: Endocrinology Authors: A.J. Rudinsky, C.A. Adin, S. Borin-Crivellenti, P. Rajala-Schultz, M.J. Hall, C. Gilor Source Type: research
Pharmacology of the glucagon-like peptide 1 analog exenatide extended-release in healthy cats
Exenatide extended-release (ER) is a microencapsulated formulation of the glucagon-like peptide 1-receptor agonist exenatide. It has a protracted pharmacokinetic profile that allows a once-weekly injection with comparable efficacy to insulin with an improved safety profile in type II diabetic people. Here, we studied the pharmacology of exenatide ER in 6 healthy cats. A single subcutaneous injection of exenatide ER (0.13 mg/kg) was administered on day 0. Exenatide concentrations were measured for 12 wk. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - December 19, 2014 Category: Endocrinology Authors: A.J. Rudinsky, C.A. Adin, S. Borin-Crivellenti, P. Rajala-Schultz, M.J. Hall, C. Gilor Source Type: research
Pharmacology of the GLP-1 analog exenatide extended-release in healthy cats
Exenatide extended-release (ER) is a microencapsulated formulation of the GLP-1-receptor agonist exenatide. It has a protracted pharmacokinetic profile that allows a once-weekly injection with comparable efficacy to insulin with an improved safety profile in type-2 diabetic people. Here we studied the pharmacology of Exenatide-ER in six healthy cats. A single subcutaneous injection of Exenatide-ER (0.13 mg/kg) was administered on day 0. Exenatide concentrations were measured for 12 wk. A hyperglycemic clamp (target = 225 mg/dL) was performed on days -7 (Clamp-I) and 21 (Clamp-II) with measurements of insulin and glucagon c...
Source: Domestic Animal Endocrinology - December 19, 2014 Category: Endocrinology Authors: A.J. Rudinsky, C.A. Adin, S. Borin-Crivellenti, P. Rajala-Schultz, M.J. Hall, C. Gilor Source Type: research
Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats
Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a protracted pharmacokinetic profile that is used in people for treatment of type II diabetes mellitus and obesity. The aim of this study was to determine the pharmacokinetics and pharmacodynamics of liraglutide in healthy cats. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - December 12, 2014 Category: Endocrinology Authors: M.J. Hall, C.A. Adin, S. Borin-Crivellenti, A.J. Rudinsky, P. Rajala-Schultz, J. Lakritz, C. Gilor Source Type: research
Pharmacokinetics and pharmacodynamics of the GLP-1 analog liraglutide in healthy cats
Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a protracted pharmacokinetic profile that is used in people for treatment of type II diabetes mellitus (T2DM) and obesity. The aim of this study was to determine the pharmacokinetics and pharmacodynamics of liraglutide in healthy cats. (Source: Domestic Animal Endocrinology)
Source: Domestic Animal Endocrinology - December 12, 2014 Category: Endocrinology Authors: M.J. Hall, C.A. Adin, S. Borin-Crivellenti, A.J. Rudinsky, P. Rajala-Schultz, J. Lakritz, C. Gilor Source Type: research
