Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone that induces glucose-dependent stimulation of insulin secretion while suppressing glucagon secretion. Glucagon-like peptide-1 also increases beta cell mass and satiation while decelerating gastric emptying. Liraglutide is a fatty-acid derivative of GLP-1 with a protracted pharmacokinetic profile that is used in people for treatment of type II diabetes mellitus and obesity. The aim of this study was to determine the pharmacokinetics and pharmacodynamics of liraglutide in healthy cats.

Source: Domestic Animal Endocrinology - December 12, 2014 Category: Endocrinology Authors: M.J. Hall, C.A. Adin, S. Borin-Crivellenti, A.J. Rudinsky, P. Rajala-Schultz, J. Lakritz, C. Gilor Source Type: research