Undernutrition regulates the expression of a novel splice variant of myostatin and IGF1 in ovine skeletal muscle

Undernutrition suppresses the growth of skeletal muscles and alters the expression of insulin-like growth factor 1 (IGF1), a key mitogen, and myostatin, a potent inhibitor of myogenesis. These changes can explain, at least in part, the reduced growth of skeletal muscles in underfed lambs. We have recently identified a myostatin splice variant (MSV) that binds to and antagonizes the canonical signalling of myostatin. In the current study, we hypothesized that expression of MSV would be reduced in conjunction with myostatin and IGF1 in response to underfeeding in skeletal muscles of sheep.

Source: Domestic Animal Endocrinology - January 19, 2015 Category: Endocrinology Authors: F. Jeanplong, C.C. Osepchook, S.J. Falconer, H.K. Smith, J.J. Bass, C.D. McMahon, J.M. Oldham Source Type: research