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Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?
Conclusion: Plateletcrit is a low-cost, widely available marker for prediction of RPL in patients with a history of at least 1 abortus. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Aynıoglu, O., Isık, H., Sahbaz, A., Harma, M. I., Isık, M., Kokturk, F. Tags: Original Articles Source Type: research

Levels of Matrix Metalloproteinases in Arthroplasty Patients and Their Correlation With Inflammatory and Thrombotic Activation Processes
An imbalance of matrix metalloproteinases (MMPs) and their inhibitors is thought to play a major role in the pathophysiology of joint diseases. The aim of this study is to provide additional insights into the relevance of MMP levels in arthroplasty patients in relation to inflammation and thrombosis. Deidentified plasma samples from 100 patients undergoing total hip arthroplasty or total knee arthroplasty were collected preoperatively, on postoperative day 1, and on postoperative day 3. Tissue inhibitor of MMP 4, tumor necrosis factor α (TNF-α), pro-MMP1, MMP3, MMP9, MMP13, and d-dimer were measured using enzym...
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Alexander, K., Banos, A., Abro, S., Hoppensteadt, D., Fareed, J., Rees, H., Hopkinson, W. Tags: Original Articles Source Type: research

A Study of Human Killer Cell Immunoglobulin-Like Receptor and Multidrug Resistance Gene Polymorphisms in Children With Immune Thrombocytopenia
Conclusion: The frequency of MDR1 polymorphisms was not associated with susceptibility to the development and clinical progression of the disease. However, KIR2 gene polymorphisms were independently associated with childhood ITP in Egyptian patients with highest prevalence among (KIRDL2–/KIRDS2–) genotypes. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: El-beblawy, N. M. S., Elbarbary, N. S., Kamal, T. M., Mahmoud, P. M. Tags: Original Articles Source Type: research

Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors
In conclusion, our findings demonstrate that heparin-calibrated antifactor Xa activity correlates strongly with apixaban and rivaroxaban concentration. The dilution of samples allowed for this correlation to be extended over the majority of on-therapy drug concentrations. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Beyer, J., Trujillo, T., Fisher, S., Ko, A., Lind, S. E., Kiser, T. H. Tags: Original Articles Source Type: research

Evidence-Based Development and Rationale for Once-Daily Rivaroxaban Dosing Regimens Across Multiple Indications
Conclusion: The evidence for each dosing regimen demonstrates that although pharmacology studies are of paramount importance, dose regimens must be subjected to careful empirical validation. Once-daily dosing was shown to be clinically appropriate for most rivaroxaban indications. Furthermore, a "one size fits all" approach to dosing frequency is unlikely to result in a regimen that yields optimal patient outcomes across different indications. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Kubitza, D., Berkowitz, S. D., Misselwitz, F. Tags: Reviews Source Type: research

The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio
Inflammation plays an important role in the pathophysiology of vascular disease. In this review, we consider the associations between the neutrophil–lymphocyte ratio (NLR; an indicator of inflammation) and vascular disease and its associated risk factors. The NLR has received attention due to its role as an independent prognostic factor for coronary artery disease. The NLR can also be affected by atherosclerotic risk factors, such as hypercholesterolemia, metabolic syndrome, diabetes, and hypertension. Importantly, it can predict mortality in cardiovascular diseases. There are also reports of a positive correlation b...
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Balta, S., Celik, T., Mikhailidis, D. P., Ozturk, C., Demirkol, S., Aparci, M., Iyisoy, A. Tags: Reviews Source Type: research

Should Low-Molecular-Weight Heparin be Preferred Over Unfractionated Heparin After Thrombolysis for Severity Pulmonary Embolism?
Conclusion: These results suggest that LMWH treatment can be used safely in patients with PE after thrombolytic therapy. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Senturk, A., Ucar, E. Y., Berk, S., Ozlu, T., Altınsoy, B., Dabak, G., Cakır, E., Kadıoglu, E. E., Sen, H. S., Ozsu, S., The TUPEG Study Investigators Tags: Original Articles Source Type: research

Thromboembolic Events in Malignant Pleural Mesothelioma
Conclusion: The rate of TEEs was 7.9%. Presence of thrombocytosis, disease stage, and histopathology did not affect the incidence of TEEs. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Koksal, D., Safak, O., Ozcan, A., Agackiran, Y., Erturk, H., Findik, G. Tags: Original Articles Source Type: research

Alterations in Blood Coagulation and Viscosity Among Young Male Cigarette Smokers of Al-Jouf Region in Saudi Arabia
Hemorheology, a measure of rheological properties of blood, is often correlated with cerebral blood flow and cardiac output; an increased blood viscosity may increase the risk of thrombosis or thromboembolic events. Previous studies have reported a large variation in hemorheological properties of blood among smokers. This prompted us to conduct coagulation experiments to evaluate the effect of cigarette smoking on hematological parameters, like cell counts, and coagulation parameters among young males in Al-Jouf region, Saudi Arabia. The hematological and coagulation parameters were used to relate the changes in viscosity ...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Almarshad, H. A., Hassan, F. M. Tags: Original Articles Source Type: research

Factor VIII Antigen, Activity, and Mutations in Hemophilia A
Factor VIII (FVIII) activity, antigen, and its gene mutation in patients may give us some insight into structure–activity relationship and probable reason for its low level in a particular patient. A total of 53 cases with hemophilia A and 17 normal individuals were analyzed for FVIII:C and FVIII:Ag levels along with their blood groups to determine their cross-reacting material (CRM) status. In all, 37 cases (18 moderate and 19 mild) were found to have discordant CRM status. Missense mutations (Ala723Thr and Lys439Ser) and protein truncating changes (Trp1854* and Arg2326*) were observed in 2 each of these cases. Alth...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Nair, P. S., Shetty, S., Ghosh, K. Tags: Original Articles Source Type: research

Enoxaparin Treatment Followed by Rivaroxaban for the Treatment of Acute Lower Limb Venous Thromboembolism: Initial Experience in a Single Center
Rivaroxaban is a target-specific oral anticoagulant approved for the treatment of venous thromboembolism (VTE). On its major clinical trials, treatment was initiated directly with a 3-week dose of oral 15 mg twice daily followed by 20 mg every day for at least 3 months. We retrospectively evaluated an initial therapy for confirmed VTE with 1 to 18 days of enoxaparin (1 mg/kg twice daily parenteral) followed by oral rivaroxaban 20 mg every day. Of 49 patients, we found no symptomatic recurrence, no major bleeding, and only 1 clinically relevant nonmajor bleeding. We concluded in this pilot study that it is safe and effectiv...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Wolosker, N., Varella, A. Y. M., Fukuda, J. M., Teivelis, M., Kuzniec, S., Krutman, M., Guerra, J. C. d. C., Ramacciotti, E. Tags: Original Articles Source Type: research

Fibrinolytic Dysregulation in Total Joint Arthroplasty Patients: Potential Clinical Implications
Conclusion: These results confirm the perturbation in the fibrinolytic system of patients undergoing total joint arthroplasty surgery. Surgical intervention may also enhance the observed changes. The alterations in the fibrinolytic system may lead to the observed hemostatic complications such as bleeding, hematoma formation, or potential need for blood transfusion. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Guler, N., Burleson, A., Syed, D., Banos, A., Hopkinson, W., Hoppensteadt, D., Rees, H., Fareed, J. Tags: Original Articles Source Type: research

Monitoring Residual Platelet Activity Among Patients With Acute Coronary Syndrome Post-PCI by Modified Impedance Whole Blood Platelet Aggregation and Release Method
In this study, RPA was tested in 133 patients with ACS postpercutaneous coronary intervention between 24 and 36 hours after a 300-mg clopidogrel loading dose by modified assay. Then, these patients were followed up for 3 months for clinical ischemic events. Meanwhile, platelet activity of 58 healthy volunteers was also tested by modified assay. Results showed that in modified assay the point of platelet magnified activation time (MAT) and maximal platelet adenosine triphosphate release values (RV) have significant differences between healthy volunteers and patients ([90.86 ± 27.60 seconds] vs [206.44 ± 58.97 ...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Cui, C., Qiao, R., Zhang, J. Tags: Original Articles Source Type: research

Comparison of Renoprotective Effect of Dabigatran With Low-Molecular-Weight Heparin
Conclusion: Dabigatran etexilate, a univalent direct thrombin inhibitor, may protect the renal tissue more effectively when compared to low-molecular-weight heparins. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Yazici, S., Karahan, O., Oral, M. K., Bayramoglu, Z., Unal, M., Caynak, B., Sagbas, E. Tags: Original Articles Source Type: research

Thrombocytopenia, Platelet Transfusion, and Outcome Following Liver Transplantation
We examined the impact of thrombocytopenia and intraoperative platelet transfusion on short-term graft and overall survival after orthotopic liver transplantation (OLT). A total of 399 patients undergoing first OLT were studied. Graft and overall survival in patients with different degrees of thrombocytopenia and with or without intraoperative platelet transfusion were described. The degree of thrombocytopenia prior to OLT did not affect graft or overall survival after transplant. However, graft survival in patients receiving platelets was significantly reduced at 1 year (P = .023) but not at 90 days (P = .093). Overall su...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Chin, J. L., Hisamuddin, S. H., OSullivan, A., Chan, G., McCormick, P. A. Tags: Original Articles Source Type: research