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Aspirin Half Maximal Inhibitory Concentration Value on Platelet Cyclooxygenase1 in Severe Type-2 Diabetes Mellitus is not Significantly Different from that of Healthy Individuals
It is implicated that diabetic patients are more resistant to aspirin therapy than patients with other diseases or healthy individuals. We evaluated the inhibitory effects of aspirin on aggregation and the cyclooxygenase activity of platelets of 10 patients with severe type-2 diabetes mellitis (DM) and compared the results with those of healthy individuals. Although platelet aggregation had a tendency to be more resistant to aspirin with the DM group, there was no significant difference in half maximal inhibitory concentration 50 values of aspirin on the cyclooxygenase activity between the patients with DM and healthy indi...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Kimura, Y., Takano, K., Satoh, K., Aida, K., Kobayashi, T., Ozaki, Y. Tags: Original Articles Source Type: research

Anticoagulant and Antithrombotic Actions of AVE5026, an Enriched Anti-Xa Hemisynthetic Ultra-Low-Molecular-Weight Heparin
Conclusions: This superior safety efficacy index in animal models in comparison with other LMWH may translate into improved antithrombotic efficacy with decreased bleeding risk. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Hoppensteadt, D. A., Gray, A., Jeske, W. P., Walenga, J. M., Fareed, J. Tags: Original Articles Source Type: research

A Randomized Trial of the Topical Effect of Antifibrinolytic Epsilon Aminocaproic Acid on Coronary Artery Bypass Surgery Without Cardiopulmonary Bypass
We assessed the effect of the topical application of epsilon-aminocaproic antifibrinolytic acid (EACA) on the pericardium of patients submitted to coronary artery bypass graft (CABG) without the use of cardiopulmonary bypass (CPB). This is a prospective, randomized, and double-blind study. We evaluated 26 patients with chronic coronary heart disease indicated for CABG without CPB (EACA and placebo groups). The analysis of the postoperative hematological results showed no difference between groups in hemoglobin and hematocrit. There was no difference between the groups regarding the postoperative bleeding through the drains...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Gurian, D. B., Meneghini, A., Abreu, L. C. d., Murad, N., Matos, L. L. d., Pires, A. C., Valenti, V. E., Breda, J. R. Tags: Original Articles Source Type: research

Cost-Effectiveness Analysis of Plasma Versus Recombinant Factor VIIa for Placing Intracranial Pressure Monitors in Pretransplant Patients With Acute Liver Failure
Both plasma- and recombinant activated factor VII (rFVIIa)-based algorithms can be used to correct coagulopathy in preliver transplant patients with acute liver failure requiring intracranial pressure monitor (ICPM) placement. A decision model was created to compare the cost-effectiveness of these methods. A 70-kg patient could receive either 1 round of plasma followed by coagulation testing or 2 units of plasma and 40 μg/kg rFVIIa. Intracranial pressure monitor is placed without coagulation testing after rFVIIa administration. In the plasma algorithm, the probability of ICPM placement was estimated based on expected in...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Pham, H. P., Sireci, A. N., Kim, C. H., Schwartz, J. Tags: Original Articles Source Type: research

Venous Thromboembolism in Patients With Myeloma: Incidence and Risk Factors in a "Real-World" Population
Myeloma has a well-described association with venous thromboembolism (VTE). There are few dedicated studies investigating the incidence and risk factors. Many assessment scores have been suggested to estimate the risk of VTE in patients with cancer but these have been validated in solid organ tumors. The records of patients with myeloma attending a university hospital between January 2007 and December 2012 were reviewed to investigate the incidence of VTE and the associated risk factors. In all, 217 patients with a mean (standard deviation) age at diagnosis of 65 (12) years were included. Of 217 patients, 12% had an episod...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Crowley, M. P., Eustace, J. A., O'Shea, S. I., Gilligan, O. M. Tags: Original Articles Source Type: research

The Efficacy of Sulodexide in the Prevention of Postthrombotic Syndrome
Conclusions: Sulodexide administration after DVT appears to be effective in preventing PTS in association with recommended management and a number of recurrent DVTs. Modalities of treatment, dosages, and timing of administration should be explored in more comprehensive and complete studies. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Luzzi, R., Belcaro, G., Dugall, M., Hu, S., Arpaia, G., Ledda, A., Ippolito, E., Corsi, M., Ricci, A., Cotellese, R., Agus, G., Errichi, B. M., Cornelli, U., Cesarone, M. R., Hosoi, M. Tags: Original Articles Source Type: research

Thrombophilia in Patients With Lower Limb Deep Veins Thrombosis (LDVT) Results of a Monocentric Survey on 103 Consecutive Outpatients
A debate concerns the utility of large screening for acquired or inherited thrombophilia. The study concerns relationship between inherited thrombophilic status and lower limb deep vein thrombosis (LDVT) and highlights the possible use of extensive thrombophilia screening to determine an emerging risk of LDVT. From January 2010 to January 2012, 103 consecutive patients with LDVT were considered. In all, 57 (55.3%) patients with LDVT showed inherited thrombophilia. The most frequent trombophilic alterations were deficiency of protein S (33 patients, 32.0%), methylentethrafolate reductase (MTHFR) gene C677T variant (22 patie...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Signorelli, S. S., Fiore, V., Puccia, G., Mastrosimone, G., Anzaldi, M. Tags: Original Articles Source Type: research

Endothelial Dysfunction in Patients With Coronary Artery Disease: Insights From a Flow-Mediated Dilation Study
Conclusion: This study confirms that FMD is reduced in patients with CAD and that such reduction in FMD is related to the extent of the disease. Therefore, FMD at the brachial artery is likely to represent a reliable indicator of CAD burden. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Manganaro, A., Ciraci, L., Andre, L., Trio, O., Manganaro, R., Saporito, F., Oreto, G., Ando, G. Tags: Original Articles Source Type: research

Relationship Between Red Cell Distribution Width and the GRACE Risk Score With In-Hospital Death in Patients With Acute Coronary Syndrome
The aim of this study was to evaluate the relationship between red cell distribution width (RDW) and Global Registry of Acute Coronary Events (GRACE) risk score in patients with unstable angina pectoris (UAP) and non-ST elevation myocardial infarction (NSTEMI). We retrospectively enrolled 193 patients with UAP/NSTEMI (mean age 63.6 ± 12.6 years; men 57%) in this study. Higher RDW values were associated with increased in-hospital mortality (P = .001). There is a significant correlation between RDW and GRACE score (P < .001). In multivariate logistic regression analysis, RDW was found to be an independent predictor...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Polat, N., Yildiz, A., Oylumlu, M., Kaya, H., Acet, H., Akil, M. A., Yuksel, M., Bilik, M. Z., Aydin, M., Ulgen, M. S. Tags: Original Articles Source Type: research

Acquired and Heritable Thrombophilia in Indian Patients With Pediatric Deep Venous Thrombosis (DVT)
In conclusion, the risk factors for venous thrombosis vary in different age groups. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Pai, N., Ghosh, K., Shetty, S. Tags: Original Articles Source Type: research

Comparative Biochemical and Functional Studies on a Branded Human Recombinant Factor VIIa and a Biosimilar Equivalent Product
This study compared the composition and functional activities of AryoSeven and NovoSeven. Each product was compared at equigravimetric (1 mg/mL) stock solution for protein content. The proteomic profile was obtained using surface-enhanced laser desorption ionization mass spectrometry. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis was carried out to determine the protein profile and Western blotting was performed using a polyclonal rabbit antihuman FVIIa antibody. The FVIIa-related antigen was also measured using a commercially available enzyme-linked immunosorbent assay method. Functional as...
Source: Clinical and Applied Thrombosis/Hemostasis - August 4, 2014 Category: Hematology Authors: Sadeghi, N., Kahn, D., Syed, D., Iqbal, O., Abro, S., Eshraghi, R., Hoppensteadt, D., Fareed, J. Tags: Original Articles Source Type: research

Platelet Reactivity and Intramyocardial Hemorrhage in Patients With ST-Segment Elevation Myocardial Infarction
The aim of the study was to analyze the relation between platelet reactivity and intramyocardial hemorrhage (IMH) in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Platelet reactivity was measured in 49 patients with means of impedance aggregometry (Multiplate) before reperfusion and repeated in the subacute phase of STEMI. Cardiovascular magnetic resonance was used to detect IMH, which was found in 16 (33%) patients. There were no differences in platelet reactivity between patients with and without IMH before reperfusion. Reassessment in the subacute phase o...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2014 Category: Hematology Authors: Małek, Łukasz A., Kłopotowski, M., Śpiewak, M., Woźniak, K., Waś, J., Miśko, J., Ruzyłło, W., Witkowski, A. Tags: Original Articles Source Type: research

Experience With Vena Cava Filters at a Large Community Hospital and Level-I Trauma Center: Indications, Complications, and Compliance Barriers
Conclusion: The study demonstrates that most IVCF are being placed for prophylaxis with low retrieval rate. This contradicts current recommendations. Moreover frequent migration and penetration of IVCF can lead to serious complications. Strict enforcement of IVCF placement guidelines and setting up of filter clinics for timely retrieval is suggested. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2014 Category: Hematology Authors: Swami, U., Annunziata, G., Fulger, I. Tags: Original Articles Source Type: research

Hypoxia Biomarkers, Oxidative Stress, and Circulating Microparticles in Pediatric Patients With Thalassemia in Upper Egypt
In conclusion, the increased tissue hypoxia, oxidative stress in β thalassemia, and its relationship with DNA damage and MPs release could explain many complications of thalassemia and may have therapeutic implications. The VEGF could serve as an important indicator for adequacy of blood transfusion in thalassemia. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2014 Category: Hematology Authors: Elsayh, K. I., Zahran, A. M., El-Abaseri, T. B., Mohamed, A. O., El-Metwally, T. H. Tags: Original Articles Source Type: research

Safety and Efficacy of Periprocedural Anticoagulation With Enoxaparin in Patients Undergoing Peripheral Endovascular Revascularization
Conclusion: We conclude that low-molecular-weight heparin either in a low-dose or high-dose regime during a peripheral EVR is safe concerning bleeding complications and acute reobstructions. The long-term follow-up showed no significant difference between our high- and low-risk groups concerning reobstruction. The periprocedural anticoagulation seems to have no influence on the long-term patency rate after peripheral EVR. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2014 Category: Hematology Authors: Brodmann, M., Dorr, A., Hafner, F., Gary, T., Froehlich, H., Kvas, E., Deutschmann, H., Pilger, E. Tags: Original Articles Source Type: research