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Lack of Impact of Cytotoxic T-Lymphocyte Antigen 4 Gene Exon 1 Polymorphism on Susceptibility to or Clinical Course of Egyptian Childhood Immune Thrombocytopenic Purpura
In conclusion, CTLA-4 exon 1 49 A>G polymorphism is not associated with susceptibility to ITP in the Egyptian population; neither it affects the clinical picture of the disease. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Radwan, E. R., Goda, R. L. M. Tags: Original Articles Source Type: research

Thrombophilic Mutations as Risk Factor for Retinal Vein Occlusion: A Case-Control Study
Conclusions: In our study, the FII G20210A and the MTHFR C677T mutations resulted significantly higher in patients than in controls; in contrast, thrombophilic mutation of FV, ACE, and PAI-1 genes was not statistically correlated with RVO. In spite of having found an association between some thrombophilic mutations and RVO, more studies with a major number of patients are necessary to determine the final role of these gene variants. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Russo, P. D., Damante, G., Pasca, S., Turello, M., Barillari, G. Tags: Original Articles Source Type: research

Thrombophilic Mutations and Polymorphisms, Alone or in Combination, and Recurrent Spontaneous Abortion
In conclusion, we found no association between the polymorphisms studied and the occurrence of RSAs. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Lino, F. L., Traina, E., Barreto, J. A., Moron, A. F., Mattar, R. Tags: Original Articles Source Type: research

Myocardial Infarctions and Other Acute Coronary Syndromes in Rare Congenital Bleeding Disorders: A Critical Analysis of All Reported Cases
Conclusion: The congenital hypocoagulability present in these patients was unable to allow a protection from acute coronary diseases. The significance of the findings is discussed. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Girolami, A., Ferrari, S., Sambado, L., Peroni, E., Cosi, E. Tags: Original Articles Source Type: research

Red Cell Distribution Width Identifies Cerebral Venous Sinus Thrombosis in Patients With Headache
Conclusion: We suppose that among patients presenting with the complaint of headache, RDW value may lead to diagnose CVST. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Demir, R., Saritemur, M., Ozel, L., Ozdemir, G., Emet, M., Ulvi, H. Tags: Original Articles Source Type: research

Hemostatic Efficacy of a Traditional Medicinal Plant Extract (Ankaferd Blood Stopper) in Bleeding Control
The aim of this study is to assess the in vivo hemostatic effect of Ankaferd Blood Stopper (ABS) on rats using a tail bleeding model. Wistar rats were randomized into 4 groups of 9 each: group 1, control, no pretreatment, irrigated with saline; group 2, no pretreatment, irrigated with ABS; group 3, control, heparin pretreatment, irrigated with saline; and group 4, heparin pretreatment, irrigated with ABS. To control bleeding, compressive dressings were placed after instilling 1 mL of either ABS or saline to the bleeding area. Without heparin pretreatment, ABS shortened hemostasis time by 1.57 minutes and reduced the amount...
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Sogut, O., Erdogan, M. O., Kose, R., Boleken, M. E., Kaya, H., Gokdemir, M. T., Ozgonul, A., Iynen, I., Albayrak, L., Dokuzoglu, M. A. Tags: Original Articles Source Type: research

Changes in Platelet, Coagulation, and Fibrinolytic Activities in Mitral Stenosis After Percutaneous Mitral Valvotomy: Role of Hemodynamic Changes and Systemic Inflammation
In conclusion, MS is associated with heightened inflammatory, platelet, thrombin, and fibrinolytic activities that decrease after PMV. Altered hemodynamics and reduced inflammatory activity might have a possible role in these changes. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Hasan-Ali, H., Mosad, E. Tags: Original Articles Source Type: research

Monitoring the Efficacy of ADP Inhibitor Treatment in Patients With Acute STEMI Post-PCI by VASP-P Flow Cytometry Assay
Conclusion: Our results hint VASP-phosphorylation assay as a relevant method for guiding and tailoring DAPT. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Fedor, M., Samoš, M., Šimonova, R., Fedorova, J., Škorňova, I., Duraj, L., Staško, J., Kovař, F., Mokaň, M., Kubisz, P. Tags: Original Articles Source Type: research

The Relationship Between Neutrophil-to-Lymphocyte Ratio and Coronary Collateral Circulation
Neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker to determine systemic inflammatory response and atherosclerosis. Our aim was to determine the relationship between NLR and development of coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD). A total of 521 consecutive patients with stable CAD who underwent coronary angiography and documented total occlusion in one of those major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell, and NLR were significantly higher in patients with poor collateral than in those with ...
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Uysal, O. K., Turkoglu, C., Sahin, D. Y., Duran, M., Yıldırım, A., Elbasan, Z., Ozkan, B., Tekin, K., Kunak, A. U., Yilmaz, Y., Kaya, M. G., Gur, M., Cayli, M. Tags: Original Articles Source Type: research

The Relationship Between Eosinophil and Cardiac Syndrome X
Conclusion: As a result, our study revealed a relationship between eosinophil count and MPV in patients with CSX. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Demir, M., Şenturk, M., Kuzeytemiz, M. Tags: Original Articles Source Type: research

Parenteral Anticoagulants Use in General Practice: A Cross-Sectional Study in South Western France
This study showed that the use of parenteral anticoagulants complies with indications and regimens of SPCs in only 1 of the 3 outpatients. Further studies should be conducted in primary care to explore reasons for such low compliance rates. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Courrier, V., Fournier, J.-P., Sommet, A., Montastruc, J.-L., Poutrain, J.-C. Tags: Original Articles Source Type: research

Practical Management of Rivaroxaban for the Treatment of Venous Thromboembolism
Traditional anticoagulants, such as low-molecular-weight heparin and vitamin K antagonists, have been the mainstay for the treatment of venous thromboembolism (VTE) in the hospital setting and after discharge. These anticoagulants are effective but are associated with some limitations that may lead to their underuse. Based on the results of the EINSTEIN clinical trial program, the oral, direct factor Xa inhibitor rivaroxaban is approved for the treatment of acute deep vein thrombosis (DVT) and pulmonary embolism (PE) and for the prevention of recurrent VTE. The single-drug approach with rivaroxaban is now available in both...
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Imberti, D., Benedetti, R. Tags: Reviews Source Type: research

Rivaroxaban in the Treatment of Venous Thromboembolism and the Prevention of Recurrences: A Practical Approach
Anticoagulation therapy is the standard treatment of patients with symptomatic venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Until recently, treatment of VTE was based on parenteral or low-molecular-weight heparin for initial therapy (5-10 days) and oral vitamin K antagonists for long-term therapy. Those treatments have some limitations, including parenteral administration (heparins), the need for frequent monitoring and dose adjustments, interactions with several medications, and dietary restrictions (vitamin K antagonists). Rivaroxaban is a new oral direct factor Xa inhibitor with a...
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Arcelus, J. I., Domenech, P., Fernandez-Capitan, M. d. C., Guijarro, R., Jimenez, D., Jimenez, S., Lozano, F. S., Monreal, M., Nieto, J. A., Paramo, J. A. Tags: Reviews Source Type: research

VEGFR-1, Bcl-2, and HO-1 Ratios in Pregnant Women With Hypertension
Conclusion: The Bcl-2 and HO-1 proteins seem to have important roles in the antiangiogenic environment of preeclampsia. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 27, 2015 Category: Hematology Authors: Varol, F., Uzunoğlu, R., Erbaş, H., Sut, N., Sayın, C. Tags: Brief Report Source Type: research

Evaluation Factors of Pulmonary Embolism Severity and Prognosis
Management of pulmonary embolism (PE) is still unclear. We summarized 16 kinds of evaluation factors of PE severity and prognosis, and we analyzed the single and joint value for short-term and long-term prognosis. Among them, biomarkers such as brain natriuretic peptide or N-terminal probrain natriuretic peptide, troponin, and heart-type fatty acid-binding protein are the best indicators of PE severity and short-term prognosis. They might replace imaging detections in evaluating PE severity. But the positive predictive value of all the biomarkers is low, and we need to improve each value through joint detection. The PE sev...
Source: Clinical and Applied Thrombosis/Hemostasis - February 27, 2015 Category: Hematology Authors: Tong, C., Zhang, Z. Tags: Original Articles Source Type: research