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Cerebral Sinovenous Thrombosis in Children and Neonates: Clinical Experience, Laboratory, Treatment, and Outcome
This study included 12 patients who were treated for CSVT at the Ankara University, School of Medicine, Department of Pediatric Neurology. This study included 5 girls (41.7%) and 7 boys (58.3%) with a mean age of symptom onset of 5.2 ± 6.29 years (range: 0-18 years), who were followed at our institution for a mean of 1.8 ± 1.73 years (range: 0-6.5 years). Among the patients, 3 had no risk factors, 2 had 1 risk factor, and 7 had multiple risk factors. Anticoagulant therapy was administered to 4 patients, of which 1 had neurological sequelae; neurological sequelae or exitus occurred in 4 of the 8 patients who d...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Bektas, O., Teber, S., Akar, N., Uysal, L. Z., Arsan, S., Atasay, B., Deda, G. Tags: Original Articles Source Type: research

Correlates of Syncope in Patients With Acute Pulmonary Thromboembolism
In conclusion, among patients with PTE, RV dysfunction and saddle embolism were the independent correlates of syncope. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Jenab, Y., Lotfi-Tokaldany, M., Alemzadeh-Ansari, M.-J., Seyyedi, S. R., Shirani, S., Soudaee, M., Ghaffari-Marandi, N. Tags: Original Articles Source Type: research

Protein Z G79A Polymorphism and Puerperal Cerebral Venous Thrombosis
Protein Z (PZ), a cofactor for PZ-dependent protease inhibitor, is known to play an important role in inhibiting the coagulation cascade. The aim of the study was to investigate whether PZ G79A polymorphism is a risk factor for puerperal cerebral venous thrombosis (CVT). A total of 71 patients with puerperal CVT and 98 healthy controls were genotyped for PZ 79GA polymorphism by polymerase chain reaction-restriction fragment length polymorphism method. In patients, the genotype distribution for GG, GA, and AA genotypes was 22.5%, 43.7%, and 33.8%, and in controls, 25.5%, 40.8%, and 33.7%, respectively. The risk associated w...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Yadav, D. D., De, T., Nagaraja, D., Christopher, R. Tags: Original Articles Source Type: research

Prothrombotic SERPINC1 Gene Polymorphism may Affect Heparin Sensitivity Among Different Ethnicities of Chinese Patients Receiving Heart Surgery
The purpose of this study was to investigate a possible correlation between single-nucleotide polymorphisms (SNPs) of the antithrombin (gene, SERPINC1, and perioperative sensitivity to heparin in patients receiving heart surgery. The SERPINC1 genotype and allele frequency, coagulation parameters 24 hours before and after surgery, and clinical findings were compared among 3 ethnic groups, Han, Uighur, and Kazakh, patientswho received heart surgery. In Han patients, longer coagulation time as well as higher heparin and protamine dosage was observed. SERPINC1 gene sequencing identified 2 mutations in exon 5, g.981A>G (rs58...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Wang, J., Ma, H.-P., Ti, A. L. T. T. L., Zhang, Y.-Q., Zheng, H. Tags: Original Articles Source Type: research

Detection of Hemophilia A Carriers in Azeri Turkish Population of Iran: Usefulness of HindIII and BclI markers
Hemophilia A (HA) is an inherited X-linked coagulation disorder caused by the deficiency of factor VIII (FVIII). Linkage analysis is a common indirect method for the detection of female carriers in families with HA. In the current study, 173 patients from 30 unrelated families with HA were recruited from the Azeri Turkish population of northwest Iran and analyzed for BclI and HindIII markers by polymerase chain reaction-restriction fragment length polymorphism. We investigated the potential of using these markers for the detection of mutation in carriers through linkage analysis, which would be of tremendous use in prenata...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Moharrami, T., Derakhshan, S. M., Pourfeizi, A. A. H., Khaniani, M. S. Tags: Original Articles Source Type: research

Improving Adherence Rate of Extended Prophylaxis for Venous Thromboembolic Disease After Abdominal and Pelvic Oncologic Surgery: A Pilot Educational Study
Conclusion: The EIP for the surgical team significantly improved their adherence but only in the colon–rectal surgeries. The adherence to the recommended guidelines is still low. Reasons could be the subjective perception of elevated bleeding risk and the variable grade of recommendation in different guidelines. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Vazquez, F. J., Bilbao, M. S., Saimovici, J., Vaccaro, C. Tags: Original Articles Source Type: research

Hepcidin is Linked to Hypoferremia in Patients With Rheumatic Valve Disease
Conclusion: Hepcidin levels are decreased independently from hs-CRP levels as a compensatory mechanism to increase the iron absorption in response to decreased serum iron levels in patients with RVD. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Akcay, M., Yeter, E., Ayhan, H., Durmaz, T., Keles, T., Kasapkara, H. A., Bilen, E., Bozkurt, E. Tags: Original Articles Source Type: research

Vascular Dysfunction in Patients With Young {beta}-Thalassemia: Relation to Cardiovascular Complications and Subclinical Atherosclerosis
We aimed to study the endothelial dysfunction among children and adolescents with transfusion-dependent β-thalassemia using von Willebrand factor antigen (VWF:Ag) and flow cytometric analysis of circulating CD144+ endothelial microparticles (EMPs) and endothelial progenitor cells (CD34+VEGFR2+) and assess their relation to iron overload, erythropoietin and chelation therapy as well as echocardiographic parameters and carotid intima–media thickness. The VWF:Ag, EMPs, and CD34+VEGFR2+ cells were significantly higher among patients with β-thalassemia than controls (P < .001). The type of chelation and patie...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Adly, A. A. M., El-Sherif, N. H., Ismail, E. A. R., El-Zaher, Y. A., Farouk, A., El-Refaey, A. M., Wahba, M. S. Tags: Original Articles Source Type: research

Home Treatment of Deep Venous Thrombosis in the Era of New Oral Anticoagulants
This is a retrospective cohort study of adults with a primary diagnosis of deep venous thrombosis (DVT) unaccompanied by pulmonary embolism (PE), seen in 4 emergency departments in 2013 and part of 2014. The purpose was to assess the prevalence of home treatment of DVT in the present era of new oral anticoagulants. Among 96 patients with DVT and no PE, 85 (88.5%) were hospitalized and 11 (11.5%) were discharged to home. Most of the patients discharged to home received low-molecular-weight heparin, 9 (81.8%) of 11. None were prescribed new oral anticoagulants. Early discharge in ≤2 days occurred 28 (32.9%) of 85 patients...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Stein, P. D., Matta, F., Hughes, P. G., Ghiardi, M., Marsh, J. H., Khwarg, J., Brandon, M. S., Fowkes, H. A. N., Kazan, V., Wiepking, M., Keyes, D. C., Kakish, E. J., Hughes, M. J. Tags: Original Articles Source Type: research

A Comparison Between Recombinant Activated Factor VII (Aryoseven) and Novoseven in Patients With Congenital Factor VII Deficiency
In order to establish the efficacy and biosimilar nature of AryoSeven to NovoSeven in the treatment of congenital factor VII (FVII) deficiency, patients received either agent at 30 μg/kg, intravenously per week for 4 weeks, in a randomized fashion. The primary aim was to compare FVII:coagulation activity (FVII:C), 20 minutes after recombinant activated FVII (rFVIIa) injection, in the 2 groups. A secondary measure was self-reported bleeding. The median interquartile baseline range of the plasma level of activated FVII (FVIIa) activity in the 2 groups was 1.6 (1.1-14.0) IU/dL and 5.0 (1.1-25.5) IU/dL. All patients achieve...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Faranoush, M., Abolghasemi, H., Toogeh, G., Karimi, M., Eshghi, P., Managhchi, M., Hoorfar, H., Dehdezi, B. K., Mehrvar, A., Khoeiny, B., Kamyar, K., Heshmat, R., Baghaeipour, M. R., Mirbehbahani, N. B., Fayazfar, R., Ahmadinejad, M., Naderi, M. Tags: Original Articles Source Type: research

Analysis of Enoxaparin Dose Titration at a Large, Tertiary Teaching Facility
Therapeutic drug monitoring of enoxaparin with antifactor Xa levels (AXALs) is recommended in some populations; however, the approach to dose titration is poorly described. Our study at a large, tertiary teaching facility examined the dose response to titration of enoxaparin based on AXAL. Patients from 2008 to 2012 receiving enoxaparin were included, provided 2 or more steady state AXAL were obtained within 30 days and that the enoxaparin was prescribed for treatment rather than prophylaxis. The primary outcome was the percentage of dose change required to obtain goal range AXAL following dose titration. Eighty-seven pati...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Freer, J. M., Green, M. S., Iuppa, J. A., Deal, E. N., Thoelke, M. S. Tags: Original Articles Source Type: research

Baseline SYNTAX Score and Long-Term Outcome in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Conclusion: The SXscore is an independent predictor of both in-hospital and long-term mortality and MACE in patients with acute STEMI undergoing primary PCI. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Akgun, T., Oduncu, V., Bitigen, A., Karabay, C. Y., Erkol, A., Kocabay, G., Ozveren, O., Yildiz, A., Cimen, A. O., Kirma, C. Tags: Original Articles Source Type: research

Clinical Relevance of Matrix Metalloproteinase 9 in Patients With Acute Coronary Syndrome
We measured levels of matrix metalloproteinase 9 (MMP-9) as a potential risk factor in 75 patients with acute coronary syndrome (ACS) compared to 25 patients with stable angina (SA) and 20 healthy participants. Patients were studied stressing on smoking, hypertension, diabetes, lipid profile, cardiac enzymes, MMP-9, and electrocardiography. Patients with ACS had higher MMP-9 levels than the SA group. The highest MMP-9 levels were found among ST-elevated myocardial infarction (MI), while the lowest levels were found among the control group. The MMP-9 level was significantly higher among patients with ACS having poor disease...
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Hamed, G. M., Fattah, M. F. A. Tags: Original Articles Source Type: research

Characterization of the Antithrombotic Fingerprint of the Branded and Copies of the Low-Molecular-Weight Enoxaparin Using Thrombin Generation Assay
Conclusion: Enoxaparin copies showed significant variability regarding their inhibitory potency on thrombin generation. Platelets and cancer cells significantly increased the variability of the antithrombotic efficiency of the copies as compared to the branded enoxaparin. The present study underlines the need for the elaboration of additional functional criteria to evaluate the global antithrombotic capacity of enoxaparin copies in order to evaluate their potential sameness with the branded drug. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 5, 2015 Category: Hematology Authors: Gerotziafas, G. T., Rouseau, A., Mbemba, E., Khartechi, A., Van Dreden, P., Walenga, J., Fareed, J., Elalamy, I. Tags: Original Articles Source Type: research

Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins
The purpose of the study was to analyze a systemic activation of hemostasis and concentration of matrix metalloproteinase 10 (MMP-10) in patients with primary varicose veins (PVVs). A study group consisted of 41 patients with noncomplicated PVVs. A control group consisted of 30 age- and sex-matched healthy individuals without varicose veins. The concentration of d-dimers (DD), prothrombin fragments 1 and 2 (F1+2), antigen of von Willebrand factor (vWF), and activity of plasminogen activator inhibitor (PAI-1) in plasma and concentration of MMP-10 in serum were analyzed. In patients with PVVs, higher concentrations of DD (P ...
Source: Clinical and Applied Thrombosis/Hemostasis - September 2, 2015 Category: Hematology Authors: Dzieciuchowicz, L., Espinosa, G., Paramo, J. A. Tags: Brief Report Source Type: research