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Biomarkers for Prediction of Central Venous Catheter Related-Thrombosis in Patients With Hematological Malignancies
Conclusion: Elevated leukocyte count, high PAI-1, and high FVIII were associated with an increased incidence of symptomatic CVC-related thrombosis. We hope in future that simple, easy to determine laboratory tests that reflect the hemostatic and fibrinolytic activity in combination with clinical parameters may help to identify hematological patients at highest risk of CVC-related thrombosis and help to tailor the management of thromboprophylaxis in hematological patients undergoing CVC placement. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Boersma, R. S., Hamulyak, K., van Oerle, R., Tuinenburg, A., ten Cate-Hoek, A. J., Schouten, H. C. Tags: Original Articles Source Type: research

Rediscussing Anticoagulation in Distal Deep Venous Thrombosis
Conclusion: Distal DVT is associated with a high incidence of PE compared to proximal DVT. Distal DVT and ICVT can provoke PE with involvement of proximal vessels in the pulmonary arterial tree, even in asymptomatic patients. Our study arises discussion in the controversial debate regarding the need for routine anticoagulation in distal DVT. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Krutman, M., Kuzniec, S., Ramacciotti, E., Varella, A. Y. M., Zlotnik, M., Teivelis, M. P., Tachibana, A., de Campos Guerra, J. C., Wolosker, N. Tags: Original Articles Source Type: research

Patterns and Predictors of Use of Anticoagulants for the Treatment of Venous Thromboembolism Following Approval of Rivaroxaban
Conclusion: Several months following its availability, rivaroxaban was rarely prescribed for acute VTE disease. It also appears to be prescribed in different patient populations than VKA. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Dault, R., Vanasse, A., Blais, L., Perreault, S., Farand, P., Le Templier, G., Beauchesne, M.-F. Tags: Original Articles Source Type: research

VKORC1 -1639 G>A Polymorphism in Romanian Patients With Deep Vein Thrombosis
Aim: The purpose of the research was to study the influence of several genetic factors, especially the -1693 G>A polymorphism of the VKORC1 gene, on the risk of acute unprovoked lower extremity deep vein thrombosis (DVT). Materials and Methods: The study included 127 patients (median age 63 [53.2; 72] years; 61 [48%] women and 66 [52%] men) who were diagnosed with acute lower extremity DVT and 114 controls (median age 62 [53; 73] years; 64 [56.1%] women and 50 [43.9%] men) without DVT. We recorded data regarding the history of DVT and the presence of varicose veins. We determined the genotypes for factor V Leiden (FVL)...
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Vesa, S. C., Trifa, A. P., Crisan, S., Buzoianu, A. D. Tags: Original Articles Source Type: research

Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model
Conclusion: This study suggests that, in trauma, fibrinogen supplementation may shorten some measurements of the speed of coagulation initiation and produce a short-lived increase in endogenous thrombin potential, potentially through increased clotting substrate availability. Approximately 12 and 24 hours after starting fibrinogen concentrate/saline infusion, all parameters measured in this study were comparable in the 2 study groups. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Zentai, C., Solomon, C., van der Meijden, P. E. J., Spronk, H. M. H., Schnabel, J., Rossaint, R., Grottke, O. Tags: Original Articles Source Type: research

Increased Level of Thrombotic Biomarkers in Patients with Atrial Fibrillation Despite Traditional and New Anticoagulant Therapy
The aim of this study was to examine the effect of the traditional oral anticoagulant, warfarin (W), and new anticoagulants, apixaban (A) and rivaroxaban (R), on the level of thrombotic biomarkers in patients with atrial fibrillation (AF). Circulating plasma levels of von Willebrand factor (vWF), prothrombin fragment 1.2 (F1.2), microparticle tissue factor (MP-TF), and plasminogen activator inhibitor (PAI-1) were analyzed as potential markers of clot formation in 30 patients with AF prior to ablation surgery. Patients with AF were divided into 2 groups based on their usage (n = 21) and nonusage (n = 9) of any oral anticoag...
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Liles, J., Liles, J., Wanderling, C., Syed, M., Hoppensteadt, D., Fareed, J. Tags: Original Articles Source Type: research

Antiphospholipid Antibodies and Procoagulant Profile in Tunisians With Inflammatory Bowel Diseases
The hypercoagulable state accompanying inflammatory bowel diseases (IBDs) is still poorly understood. The aim of this study was to assess antiphospholipid antibodies (APAs) and a large panel of inherited and acquired thrombotic markers simultaneously in a sample of Tunisian patients with IBD. In total, 89 consecutive patients with IBD (mean age 38 ± 15 years; 48 with Crohn disease and 41 with ulcerative colitis) and 129 controls were prospectively evaluated for immunoglobulin (Ig) G, IgM, and IgA antibodies against cardiolipin (aCL), β2glycoprotein I (aβ2GPI), and prothrombin (aPT); IgG and IgM antibodies ...
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Kraiem, I., Hadhri, S., Ben Rejeb, M., Ifa, L., Jmaa, A., Ajmi, S., Skouri, H. Tags: Original Articles Source Type: research

The Effect of Danazol in Primary Immune Thrombocytopenia: An Analysis of a Large Cohort From a Single Center in China
Conclusion: Low-to-medium dosage of danazol is better tolerated and effective in patients with ITP, even in those refractory to other treatments. Combination of danazol and glucocorticoids for initial treatment may decrease relapse rates to achieve well-tolerated long-term remission. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Liu, W., Gu, X., Fu, R., Li, Y., Lv, M., Sun, T., Lv, C., Liu, X., Xue, F., Zhang, L., Yang, R. Tags: Original Articles Source Type: research

Serum and Urinary Orosomucoid in Young Patients With Type 1 Diabetes: A Link Between Inflammation, Microvascular Complications, and Subclinical Atherosclerosis
Orosomucoid is an acute-phase serum protein that is upregulated in urine samples of patients with diabetic nephropathy. We assessed serum and urinary orosomucoid levels in children and adolescents with type 1 diabetes and their relation to microvascular complications and carotid intima–media thickness (CIMT). Sixty patients with type 1 diabetes were divided into 2 groups according to the presence of microvascular complications and compared with 60 healthy controls. High-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), urinary albumin–creatinine ratio (UACR), serum and urinary orosomucoid, and CI...
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: El-Beblawy, N. M. S., Andrawes, N. G., Ismail, E. A. R., Enany, B. E.-S., El-Seoud, H. S. A., Erfan, M. A. Tags: Original Articles Source Type: research

Efficacy and Safety of Fondaparinux in Patients With Suspected Heparin-Induced Thrombocytopenia
Conclusion: In this small retrospective review, fondaparinux appeared similarly efficacious and safe compared to DTIs for the treatment of suspected HIT. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Snodgrass, M. N., Shields, J., Rai, H. Tags: Original Articles Source Type: research

Acquired Isolated FVII Deficiency: An Underestimated and Potentially Important Laboratory Finding
Conclusions: Isolated FVII deficiency is a rare defect, which appears to be a finding associated with several morbid conditions, especially sepsis and tumors. This indicates the need for a careful investigation of even a mild prolongation of prothrombin time, especially when fibrinogen and partial thromboplastin time are normal. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Girolami, A., Santarossa, C., Cosi, E., Ferrari, S., Lombardi, A. M. Tags: Review Source Type: research

Thromboelastography as a Surrogate Marker of Perisurgical Hemostasis in Gaucher Disease
Thromboelastography (TEG) has long been available for routine monitoring of perisurgical and postpartum hemostasis, especially at point of care. The purpose of this study is to retrospectively compare TEG parameters to concomitant standard clotting test results in an unselected cohort of patients with Gaucher disease to ascertain whether TEG values are specific and sensitive enough to substitute for classic coagulation tests for decision making. This remains a cogent concern because of high incidence of thrombocytopenia in patients with Gaucher disease. Thromboelastography values were compared to concomitant platelet count...
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Ioscovich, A., Fadeev, D., Kenet, G., Naamad, M., Schtrechman, G., Zimran, A., Elstein, D. Tags: Original Articles Source Type: research

Treatment of Postpartum Hemorrhage With Blood Products in a Tertiary Hospital: Outcomes and Predictive Factors Associated With Severe Hemorrhage
Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality and morbidity worldwide. This retrospective observational study describes patient characteristics and hemostatic therapies administered to 352 parturients experiencing PPH and analyzes risk factors for developing severe PPH. During the study period, bleeding was controlled in all cases and 99.4% survived. The majority (98%) of patients received packed red blood cells. The most frequent hemostatic therapies administered were fibrinogen concentrate (56%), fresh frozen plasma (49%), and platelets (30%). A total of 124 (35%) women experienced severe PPH....
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Guasch, E., Gilsanz, F. Tags: Original Articles Source Type: research

Plasma Concentrations of Protein Z and Protein Z-Dependent Protease Inhibitor in Patients With Essential Thrombocythemia
The pathological consequences of decreased protein Z (PZ) and/or Z-dependent protease inhibitor (ZPI) levels remain as yet unclear, despite a growing body of evidence which supports their involvement in an increased thrombotic risk. The purpose of the present study was 2-fold: to evaluate plasma concentrations of protein Z and ZPI in patients with essential thrombocythemia (ET) and to determine their significance in thrombotic complications. The median (range) plasma concentrations of PZ in our patients with ET were lower, but not significantly, than in healthy individuals: PZ (1.42 µg/mL, 0.36-3.14 µg/mL vs 1....
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Szumowska, A., Galar, M., Bolkun, L., Kloczko, J. Tags: Original Articles Source Type: research

Effects of Paclitaxel on the Ability of Aspirin and Clopidogrel to Inhibit Platelet Aggregation
In conclusion, paclitaxel can reduce the ability of aspirin, clopidogrel, and aspirin combined with clopidogrel to inhibit platelet aggregation. Furthermore, the ability to inhibit platelet aggregation was weakened as paclitaxel concentration increased in all 3 experimental groups. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Zhang, S., Sun, C., Hu, H., He, Y., Yao, Y., Cao, Y., Zeng, Z. Tags: Original Articles Source Type: research