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Retrospective Evaluation of Oral Anticoagulant Therapy may not Reveal the Reality
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Basaran, O., Basaran, N. F., Dogan, V., Biteker, M. Tags: Letters to the Editor Source Type: research

Prevalence of the Factor V E666D Mutation and Its Correlation With Activated Protein C Resistance in the Chinese Population
Conclusions: The prevalence of APCR either in the nonthrombotic patients or in the patients with thrombosis was lower than that reported in other Chinese studies. Our study couldn’t provide illustration whether FV E666D mutation is correlated with APCR in the Chinese population. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Xin-guang, C., Yong-qiang, Z., Shu-jie, W., Lian-kai, F., Hua-cong, C. Tags: Original Articles Source Type: research

The Association Between the Neutrophil-to-Lymphocyte Ratio and the Presence of Ventricular Premature Contractions in Young Adults
In conclusion, the NLR is independently and significantly associated with VPC existence. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Yildiz, A., Oylumlu, M., Yuksel, M., Aydin, M., Polat, N., Acet, H., Akil, M. A., Bilik, M. Z., Kaya, H., Ertas, F. Tags: Original Articles Source Type: research

Thrombomodulin is a Strong Predictor of Multiorgan Dysfunction Syndrome in Patients With Sepsis
Conclusion: The level of thrombomodulin not only was able to distinguish the severity of sepsis but also was a significant predictor of MODS development. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Mihajlovic, D. M., Lendak, D. F., Draskovic, B. G., Mikic, A. S. N., Mitic, G. P., Cebovic, T. N., Brkic, S. V. Tags: Original Articles Source Type: research

The Relation of Platelet-Lymphocyte Ratio and Coronary Collateral Circulation in Patients With Stable Angina Pectoris and Chronic Total Occlusion
Conclusion: PLR may be an important, simple, and cost effective tool predicting the degree of collateralization in patients with SAP and CTO. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Acar, G., Kalkan, M. E., Avci, A., Alizade, E., Tabakci, M. M., Toprak, C., Ozkan, B., Alici, G., Esen, A. M. Tags: Original Articles Source Type: research

Clopidogrel Plus Aspirin Prevents Early Neurologic Deterioration and Improves 6-Month Outcome in Patients With Acute Large Artery Atherosclerosis Stroke
Conclusion: Clopidogrel plus aspirin is superior to aspirin alone for reducing END and RIS within 30 days and improves outcomes in certain subgroups at 6 months. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Wang, C., Yi, X., Zhang, B., Liao, D., Lin, J., Chi, L. Tags: Original Articles Source Type: research

White Blood Cell Subtypes and Neutrophil-Lymphocyte Ratio in Prediction of Coronary Thrombus Formation in Non-ST-Segment Elevated Acute Coronary Syndrome
Leukocytes are reported as crucial not only for plaque activation but also in thrombus formation in acute coronary syndromes (ACSs). Among the markers of inflammation, in coronary artery disease neutrophil–lymphocyte ratio (NLR) has been reported to have the greatest predictive power of poor outcomes. Our aim was to evaluate the association of NLR with coronary thrombus in patients with non-ST-segment elevated ACSs (NST-ACSs). A total of 251 patients were hospitalized with a diagnosis of NST-ACS including non-ST-segment elevated myocardial infarction and unstable angina pectoris. Coronary angiographies were performed...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Yilmaz, M., Tenekecioglu, E., Arslan, B., Bekler, A., Ozluk, O. A., Karaagac, K., Agca, F. V., Peker, T., Akgumus, A. Tags: Original Articles Source Type: research

Laboratory Assessment of the Anticoagulant Activity of Dabigatran
Conclusion: The role of ETP in estimating anticoagulant activity of dabigatran possibly requires further research. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Kyriakou, E., Ikonomidis, I., Stylos, D., Bonovas, S., Papadakis, I., Nikolopoulos, G. K., Kokoris, S., Kalantzis, D., Economopoulou, C., Kopterides, P., Lekakis, J., Tsantes, A. E. Tags: Original Articles Source Type: research

Is There Any Association Between Thrombosis and Tissue Factor Pathway Inhibitor Levels in Patients With Vitamin D Deficiency?
Conclusion: Further studies are needed for evaluation of the role of TFPI in hemostasis and thrombotic process in patients with vitamin D deficiency. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Topaloglu, O., Arslan, M. S., Karakose, M., Ucan, B., Ginis, Z., Cakir, E., Akkaymak, E. T., Sahin, M., Ozbek, M., Cakal, E., Delibasi, T. Tags: Original Articles Source Type: research

Investigation of Proposed Mechanisms of Chemotherapy-Induced Venous Thromboembolism: Endothelial Cell Activation and Procoagulant Release Due to Apoptosis
Conclusions: During chemotherapy for breast cancer, VECA is induced; however, this is not the primary mechanism for VTE. Chemotherapy-induced apoptosis may enhance hypercoagulability and initiate VTE. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Kirwan, C. C., McCollum, C. N., McDowell, G., Byrne, G. J. Tags: Original Articles Source Type: research

Evaluation of the Practice Pattern of Medical Patients' VTE Prophylaxis With a Standard Risk Assessment Model Form: MERAM Study
This study aimed to determine VTE prophylaxis practices for inpatients in Turkey and to evaluate the impact of physicians’ training via a modified "Standard Medical Patients’ VTE Risk Assessment Model (MERAM)." A total of 607 inpatients included in this national multicenter noninterventional observational registry were evaluated in terms of demographics, VTE risk, and preventive measures at 2 consecutive cross-sectional visits. Physicians were asked to complete a questionnaire on current VTE method risk assessment and other models including MERAM. The VTE prophylaxis rates significantly increased from 49.4% to ...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Ongen, G., Demir, M., Molinas, N., Ince, B., Ongen, Z. Tags: Original Articles Source Type: research

Immunoenzymatic and Biochip Array Profiling of the Biomarkers of Inflammation and Hemostatic Activation Processes in ESRD
In this study, 72 patients on maintenance hemodialysis were recruited and 53 normal healthy male and female adults volunteers. Blood samples from patients with ESRD were drawn prior to maintenance hemodialysis. Of the 15 statistically significant biomarkers, 10 were elevated in the ESRD group, most notably soluble tumor necrosis factor receptor 1, heart-type fatty acid binding protein, and von Willebrand factor activity. These results are consistent with previously reported studies proposing ESRD represents a poly-pathologic process with the activation of hemostatic and inflammatory processes, which contribute to the signi...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Richards, J., Bansal, V., Iqbal, O., Hoppensteadt, D., Fareed, J. Tags: Original Articles Source Type: research

Immune Thrombocytopenia: Recent Progress in Pathophysiology and Treatment
Immune thrombocytopenia (ITP) is a rare autoimmune disorder with an incidence of 3 to 5 per 100 000 individuals. In children, the disease is self-limited and is most commonly virus related (acute ITP) whereas in adults, the disease is typically chronic. The age distribution of adult ITP displays 2 peaks; the first in younger adults aged 18 to 40 with a female predominance and the second in people aged older than 60 with men and women affected equally. Our approach to ITP has evolved over the past several years: there has been a change in nomenclature and ITP now denotes "immune thrombocytopenia" (the "I" no longer denoting...
Source: Clinical and Applied Thrombosis/Hemostasis - May 26, 2015 Category: Hematology Authors: Abadi, U., Yarchovsky-Dolberg, O., Ellis, M. H. Tags: Review Source Type: research

Red Cell Distribution Width in Patients With Cerebral Venous Sinus Thrombosis
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Balta, S., Karademir, I., Demirkol, S., Ozturk, C., Celik, T. Tags: Letter to the Editor Source Type: research

Relation of Neutrophil-to-Lymphocyte Ratio With GRACE Risk Score to In-Hospital Cardiac Events in Patients With ST-Segment Elevated Myocardial Infarction
In this study, we aimed to investigate the association of the neutrophil-to-lymphocyte ratio (NLR) with Global Registry of Acute Coronary Events (GRACE) risk score in patients with ST-segment elevated myocardial infarction (STEMI). We analyzed 101 consecutive patients with STEMI. Patients were divided into 3 groups by use of GRACE risk score. The association between NLR and GRACE risk score was assessed. The NLR showed a proportional increase correlated with GRACE risk score (P < .001). The occurrence of in-hospital cardiac death, reinfarction, or new-onset heart failure was significantly related to NLR at admission (P ...
Source: Clinical and Applied Thrombosis/Hemostasis - March 30, 2015 Category: Hematology Authors: Oncel, R. C., Ucar, M., Karakas, M. S., Akdemir, B., Yanikoglu, A., Gulcan, A. R., Altekin, R. E., Demir, I. Tags: Original Articles Source Type: research