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Mean Platelet Volume as a Surrogate Marker for Platelet Activation in Patients With Idiopathic Pulmonary Fibrosis
Conclusions: Patients with IPF exhibit higher MPV values and lower platelet count. Further studies are needed to assess the clinical implications of these findings. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Ntolios, P., Papanas, N., Nena, E., Boglou, P., Koulelidis, A., Tzouvelekis, A., Xanthoudaki, M., Tsigalou, C., Froudarakis, M. E., Bouros, D., Mikhailidis, D. P., Steiropoulos, P. Tags: Original Articles Source Type: research

The Effect of Vitamin D Supplementation on Thrombin Generation Assessed by the Calibrated Automated Thrombogram
This study aimed to examine the relationship between vitamin D supplementation and thrombin generation. Serum 25-hydroxyvitamin D (25(OH)D) and thrombin generation parameters were measured in 73 healthy volunteers. Participants with serum 25(OH)D <50 nmol/L (n = 53) were treated with vitamin D3 and tested for 25(OH)D and thrombin generation at the end of treatment. Lag time and time to peak decreased after treatment by a mean of –0.49 ± 0.51 minute (P < .001) and –0.76 ± 0.70 minute (P < .001), respectively, whereas endogenous thrombin potential and peak height increased after treatment b...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Saliba, W., Awad, K., Ron, G., Elias, M. Tags: Original Articles Source Type: research

Effects of Hyperbaric and Decompression Stress on Blood Coagulation and Fibrinolysis: Comparison of Thromboelastography and Thromboelastometry
Hyperbaric and decompression stress from diving impairs blood coagulation and fibrinolysis. We hypothesized that thromboelastography (TEG) and rotational thromboelastometry (ROTEM) were suitable to characterize the effects of stress on global hemostatic profiles. We thus conducted a comparative study of the hyperbaric effects on human coagulation using TEG and ROTEM. Maximum clot strength (maximum amplitude [MA]) and clot lysis (lysis index at time 30 minutes [LI30]) were reduced as indicated by TEG MA and EXTEM LI30, respectively. The relative changes in coagulation and fibrinolysis by the hyperbaric effects of diving wer...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Peng, H. T., Cameron, B. A., Rhind, S. G. Tags: Original Articles Source Type: research

Evaluation of Thrombin Generation Assay in Patients With Hemophilia
We evaluated the correlation between thrombin generation (TG) parameters with bleeding symptoms and disease severity in patients with hemophilia. In this cross-sectional study, 59 patients with hemophilia without inhibitors and regardless of their severity were randomly selected from southern Iran and TG assays were conducted. Bleeding score (BS) was calculated by performing a clinical evaluation using Tosetto questionnaire. Only lag time showed a statistically significant correlation with BS (rs = .316, P = .016). All TG parameters except peak showed association with disease severity (P < .05). Endogenous thrombin po...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Haghpanah, S., Bazrafshan, A., Silavizadeh, S., Dehghani, J., Afrasiabi, A., Karimi, M. Tags: Original Articles Source Type: research

Inflammation and Hemostatic Activation may Contribute to Postsurgical Thrombosis in Patients With Bladder Cancer
The alterations of the inflammatory and thrombotic components in patients with cancer are not clearly understood. The purpose of this study was to profile markers of inflammation and thrombotic activation specifically in the patients with bladder cancer undergoing radical cystectomy. For this study, 134 samples were collected from patients undergoing radical cystectomy. Antiphospholipid antibodies (immunoglobulin G subtype), microparticles, and antiglycosaminoglycan antibodies were measured with a commercially available enzyme-linked immunosorbent assay kits. These biomarkers were compared in patients with bladder cancer a...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Abro, S., Clark, M., Barkan, G., Hoppensteadt, D., Fareed, J., Wojick, E., Quek, M. Tags: Original Articles Source Type: research

Fish Intake and Venous Thromboembolism: A Systematic Literature Review
Diet plays an important role in modulating the risk of arterial and venous thrombosis. Several lines of evidence attest that consumption of fish and its compounds, especially omega-3 fatty acids, may be effective to decrease the cardiovascular risk. Since the pathogenesis of arterial and venous thrombosis share some common aspects, we performed a systematic review of published clinical studies that investigated the association between fish intake and venous thrombosis. An electronic search was carried out in Medline, Scopus, and ISI Web of Science using the key words "fish" OR "seafood" AND "venous thromboembolism" OR "dee...
Source: Clinical and Applied Thrombosis/Hemostasis - April 3, 2016 Category: Hematology Authors: Mattiuzzi, C., Cervellin, G., Franchini, M., Lippi, G. Tags: Review Source Type: research

Hypercholesterolemia is Accounted for Atherosclerosis at the Proximal Arterial Segments of Myocardial Bridging: A Pilot Study
Arterial shear stress was generally implicated in the development of atherosclerotic plaque (AP). Atherosclerotic plaque may be associated with myocardial bridging (MB). We evaluated the metabolic abnormalities which could determine the localization of AP at the proximal coronary segment of MB. We analyzed the patients with MB, AP&MB, and AP on left anterior descending (LAD) artery who were diagnosed by multislice computed tomography coronary angiography. Serum levels of metabolic parameters were compared among study groups. Patients with MB&AP and AP were significantly older than those in the MB group. Patients wi...
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Aparci, M., Ozturk, C., Balta, S., Okutucu, S., Isilak, Z. Tags: Original Articles Source Type: research

Evaluation of Risk Factors for Rectus Sheath Hematoma
Rectus sheath hematoma (RSH) develops due to rupture of epigastric arteries or the rectus muscle. Although RSH incidence rate is low, it poses a significant diagnostic dilemma. We evaluated the risk factors for RSH, its presentation, management, and outcomes for 115 patients hospitalized with confirmed RSH by computed tomography scan between January 2005 and June 2009. More than three-fourth (77.4%) of the patients were on anticoagulation therapy, 58.3% patients had chronic kidney disease (CKD) stage ≥3, 51.3% had abdominal injections, 41.7% were on steroids/immunosuppressant therapy, 37.4% had abdominal surgery/trauma,...
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Sheth, H. S., Kumar, R., DiNella, J., Janov, C., Kaldas, H., Smith, R. E. Tags: Original Articles Source Type: research

Risk of Venous Thromboembolic Events in Pregnant Patients With Autoimmune Diseases: A Population-Based Study
Conclusion: Most autoimmune diseases considerably increase the risk of VTE. Thromboprophylaxis may be considered in pregnancies with autoimmune disease, particularly those with systemic lupus erythematosus and dermatomyositis. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Bleau, N., Patenaude, V., Abenhaim, H. A. Tags: Original Articles Source Type: research

Predictors of Inhospital Mortality in Geriatric Patients Presenting to the Emergency Department With Ischemic Stroke
Conclusion: In evaluating geriatric patients with ischemic stroke, laboratory values including platelet count, creatinine levels, hyperglycemia, and NIHSS scores should be considered to predict inhospital mortality in the ED. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Dogan, N. O., Akıncı, E., Gümüs, H., Akıllı, N. B., Aksel, G. Tags: Original Articles Source Type: research

Perioperative Factors and Their Effect on the Fibrinolytic System in Arthroplasty Patients
Conclusion: These results confirm that advanced age and elevated BMI positively contribute to fibrinolytic dysregulation in TJA patients, whereas TXA seems to decrease the fibrinolytic activity. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Burleson, A., Guler, N., Banos, A., Syed, D., Wanderling, C., Hoppensteadt, D., Rees, H., Fareed, J., Hopkinson, W. Tags: Original Articles Source Type: research

Venous Thromboembolism in Critically Ill Medical Patients Receiving Chemoprophylaxis: A Focus on Obesity and Other Risk Factors
Conclusions: The rate of VTE in critically ill medical patients remains high despite standard chemoprophylaxis. Obesity is among 8 risk factors independently associated with 90-day VTE. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Fontaine, G. V., Vigil, E., Wohlt, P. D., Lloyd, J. F., Evans, R. S., Collingridge, D. S., Stevens, S. M., Woller, S. C. Tags: Original Articles Source Type: research

Adherence to Anticoagulant Therapy in Pediatric Patients Hospitalized With Pulmonary Embolism or Deep Vein Thrombosis: A Retrospective Cohort Study
Conclusion: Nearly one-third of the pediatric patients on anticoagulant therapy after discharge from PE or DVT were still nonadherent. Further research is needed to highlight the factors responsible for nonadherence in pediatric patients. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Singh, R. R., Gupte-Singh, K. R., Wilson, J. P., Moffett, B. S. Tags: Original Articles Source Type: research

Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction
Conclusions: An association was found between reduced levels of VWF: CB/VWF: Ag, ADAMTS13/VWF: Ag, and ADAMTS13/VWF: Rcof ratios and cerebral infarction. Our data suggest that increased levels of VWF and reduced levels of ADAMTS13 activity may contribute to the pathogenesis of cerebral infarction. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Qu, L., Jiang, M., Qiu, W., Lu, S., Zhao, Y., Xia, L., Ruan, C., Zhao, Y. Tags: Original Articles Source Type: research

Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by dysregulation of T cells. Programmed death (PD) 1 and programmed death 1 ligand 1 (PD-L1) are cosignaling molecules, and the major role of the PD-1 pathway is the inhibition of self-reactive T cells and to protect against autoimmune diseases. We measured levels of serum soluble PD 1 (sPD-1) and serum soluble PD-L1 (sPD-L1) in 67 patients with ITP (24 newly diagnosed ITP [ndITP], 43 chronic ITP [cITP]) and 21 healthy controls (HCs). We determined decreased serum sPD-1 levels both in patients with ndITP and in patients with cITP when compared to HC. More...
Source: Clinical and Applied Thrombosis/Hemostasis - February 22, 2016 Category: Hematology Authors: Birtas Atesoglu, E., Tarkun, P., Demirsoy, E. T., Geduk, A., Mehtap, O., Batman, A., Kaya, F., Cekmen, M. B., Gulbas, Z., Hacıhanefioglu, A. Tags: Original Articles Source Type: research