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Thrombophilia in 67 Patients With Thrombotic Events After Starting Testosterone Therapy
We compared thrombophilia in 67 cases (59 men and 8 women) with thrombotic events after starting testosterone therapy (TT) versus 111 patient controls having unprovoked venous thrombotic events without TT. In the 67 patients, thrombosis (47 deep venous thrombosis–pulmonary embolism, 16 osteonecrosis, and 4 ocular thrombosis) occurred 6 months (median) after starting TT. Cases differed from controls for factor V Leiden heterozygosity (16 of the 67 [24%] vs 13 [12%] of the 111, P = .038) and for lupus anticoagulant (9 [14%] of the 64 vs 4 [4%] of the 106, P = .019). After a first thrombotic event and continuing TT, 11 ...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Glueck, C. J., Prince, M., Patel, N., Patel, J., Shah, P., Mehta, N., Wang, P. Tags: Original Articles Source Type: research

Serum Apelin 13 Levels in Patients With Pulmonary Embolism
Conclusion: This study demonstrated that apelin 13 levels are elevated in patients with PE. These results suggest that apelin may be a novel biomarker and a potential therapeutic target in patients with acute PE in the future. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Selimoglu Sen, H., Kaplan, I., Abakay, O., Sezgi, C., Yilmaz, S., Taylan, M., Abakay, A., Tanrikulu, A. C. Tags: Original Articles Source Type: research

Association of Hemostatic Gene Polymorphisms With Early-Onset Ischemic Heart Disease in Egyptian Patients
The association between hereditary thrombophilia and venous thrombosis is well established but controversial data exist with respect to arterial thrombosis. We performed a pilot study on 31 patients with acute myocardial infarction (AMI), 21 patients with unstable angina (UA), and 20 healthy volunteers to investigate the role of various hemostatic gene polymorphisms in young Egyptian patients, who survived their first ischemic heart disease (IHD). Thrombophilic gene polymorphisms were tested using multiplex polymerase chain reaction and reverse-hybridization technique. We showed an increased risk of AMI with factor V (FV) ...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Alkhiary, W., Azzam, H., Yossof, M. M. A., Aref, S., Othman, M., El-Sharawy, S. Tags: Original Articles Source Type: research

Real-World Impact of Setting a Narrow International Normalized Ratio Target Range in the Management of Older Adult Patients on Warfarin
Conclusion: Patients assigned to a narrow INR target range in real-world practice spent a significantly lower amount of time below an INR of 3.0 compared to conventional INR target range with lower incidents of bleeding complications and no increase in subtherapeutic INRs. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Ong, P. Y. S., Koomanan, N., Cheen, M. H. H., Lai, Y. F., Lim, S. H., Kong, M. C., Ng, H. J. Tags: Original Articles Source Type: research

Analysis of Heparins Derived From Bovine Tissues and Comparison to Porcine Intestinal Heparins
Heparin is a widely used clinical anticoagulant. It is also a linear glycosaminoglycan with an average mass between 10 and 20 kDa and is primarily made up of trisulfated disaccharides comprised of 1,4-linked iduronic acid and glucosamine residues containing some glucuronic acid residues. Heparin is biosynthesized in the Golgi of mast cells commonly found in the liver, intestines, and lungs. Pharmaceutical heparin currently used in the United States is primarily extracted from porcine intestines. Other sources of heparin including bovine intestine and bovine lung are being examined as potential substitutes for porcine intes...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: St Ange, K., Onishi, A., Fu, L., Sun, X., Lin, L., Mori, D., Zhang, F., Dordick, J. S., Fareed, J., Hoppensteadt, D., Jeske, W., Linhardt, R. J. Tags: Original Articles Source Type: research

Prothrombotic Risk Factors and Preventive Strategies in Adolescent Venous Thromboembolism
Venous thromboembolism (VTE) in adolescents is a serious condition that requires prompt recognition and optimal management to prevent mortality and long-term morbidity. Adolescents account for a large proportion of cases of VTE in children. As teenagers transition from childhood to adulthood, they are at risk of developing medical conditions and exposure to risky habits that predispose them to VTE. This review focuses on the variety of risk factors and comorbidities seen in adolescent VTE and takes a quick look into risk-based preventive strategies for primary and secondary prevention. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Srivaths, L., Dietrich, J. E. Tags: Reviews Source Type: research

A Snapshot of Coagulopathy After Cardiopulmonary Bypass
Cardiac surgery involving cardiopulmonary bypass (CPB) is often associated with important blood loss, allogeneic blood product usage, morbidity, and mortality. Coagulopathy during CPB is complex, and the current lack of uniformity for triggers and hemostatic agents has led to a wide variability in bleeding treatment. The aim of this review is to provide a simplified picture of the data available on patients’ coagulation status at the end of CPB in order to provide relevant information for the development of tailored transfusion algorithms. A nonsystematic literature review was carried out to identify changes in coagu...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Höfer, J., Fries, D., Solomon, C., Velik-Salchner, C., Ausserer, J. Tags: Reviews Source Type: research

The Relation Between Endocan Levels and Subclinic Atherosclerosis
(Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Balta, S., Demirkol, S., Ozturk, C., Yildirim, A. O., Demir, M., Celik, T. Tags: Letter to the Editor Source Type: research

Risk Characteristics of Venous Thromboembolism in Chinese Patients
Conclusions: This registry demonstrated the different risk characteristics in Chinese patients compared to Western patients. Our results will be available for establishing the prevention of VTE in China. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Wang, H., Ye, J., Wang, L., Jin, W. Tags: Original Articles Source Type: research

The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial
This study could not support the potential benefit of the high-dose vitamin D on plasma level of P-selectin and hs-CRP in patients with VTE. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Gholami, K., Talasaz, A. H., Entezari-Maleki, T., Salarifar, M., Hadjibabaie, M., Javadi, M. R., Dousti, S., Hamishehkar, H., Maleki, S. Tags: Original Articles Source Type: research

Association of Monocyte-to-HDL Cholesterol Ratio with Slow Coronary Flow is Linked to Systemic Inflammation
Conclusion: Higher MHR which indicates an enhanced inflammation and oxidative stress was significantly and independently associated with the presence of SCF. Besides, MHR was positively correlated with serum hsCRP level as a conventional marker for systemic inflammation. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Canpolat, U., Cetin, E. H., Cetin, S., Aydin, S., Akboga, M. K., Yayla, C., Turak, O., Aras, D., Aydogdu, S. Tags: Original Articles Source Type: research

Evaluation of the Value of D-Dimer, P-Selectin, and Platelet Count for Prediction of Portal Vein Thrombosis After Devascularization
Conclusion: The level of d-dimer, P-selectin, and platelet count might be good candidate predictive markers for PVT in patients with cirrhotic PHT after devascularization. The combined test of the 3 markers can increase the value of prediction. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Fei, Y., Zong, G.-q., Chen, J., Liu, R.-m. Tags: Original Articles Source Type: research

Elevated Levels of LDL-C are Associated With ApoE4 but Not With the rs688 Polymorphism in the LDLR Gene
Conclusion: Our results show that carrier women of the ApoE4 isoform are more likely to have elevated levels of LDL-C and therefore increased risk of developing atherosclerosis. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Cahua-Pablo, G., Cruz, M., Moral-Hernandez, O. d., Leyva-Vazquez, M. A., Antunez-Ortiz, D. L., Cahua-Pablo, J. A., Alarcon-Romero, L. d. C., Ortuno-Pineda, C., Moreno-Godinez, M. E., Hernandez-Sotelo, D., Flores-Alfaro, E. Tags: Original Articles Source Type: research

Clinical Characteristics and Outcome of Cardiovascular Implantable Electronic Device Infections in Turkey
Infection is one of the most devastating outcomes of cardiovascular implantable electronic device (CIED) implantation and is related to significant morbidity and mortality. In our country, there is no evaluation about CIED infection. Therefore, our aim was to investigate clinical characteristics and outcome of patients who had infection related to CIED implantation or replacement. The study included 144 consecutive patients with CIED infection treated at 11 major hospitals in Turkey from 2005 to 2014 retrospectively. We analyzed the medical files of all patients hospitalized with the diagnosis of CIED infection. Inclusion ...
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Aydin, M., Yildiz, A., Kaya, Z., Kaya, Z., Basarir, A. O., Cakmak, N., Donmez, I., Morrad, B., Avci, A., Demir, K., Cagliyan, E. C., Yuksel, M., Elbey, M. A., Kayan, F., Ozaydogdu, N., Islamoglu, Y., Cayli, M., Alan, S., Ulgen, M. S., Ozhan, H. Tags: Original Articles Source Type: research

Evaluation of Factor Xa-Specific Chromogenic Substrate Assays and the Determination of Pharmacokinetics of Fondaparinux
Fondaparinux (FPX), a synthesized factor Xa inhibitor, is one of the most popular anticoagulants for the prevention of postoperative venous thromboembolism (VTE). Although routine monitoring is not required, the bleeding adverse events cannot be neglected, and the measurement of anti-Xa activity is expected to be monitored. The primary purpose of this study is to evaluate the performances of 2 chromogenic assays for the detection of anti-Xa activity. Furthermore, the pharmacokinetics of FPX was examined using chromogenic assays. Anti-Xa activity was measured using 2 FPX-based chromogenic substrates (S2222 and STA-Liquid An...
Source: Clinical and Applied Thrombosis/Hemostasis - May 28, 2016 Category: Hematology Authors: Yuri, M., Tabe, Y., Tsuchiya, K., Sadatsuki, R., Aoki, J., Horii, T., Iba, T., Ohsaka, A. Tags: Original Articles Source Type: research