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Cerebral Venous Sinus Thrombosis: Clinical Characteristics and Factors Influencing Clinical Outcome
In conclusion, successful recanalization substantially helps to achieve good clinical outcome in patients with CVST. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Krajickova, D., Klzo, L., Krajina, A., Vysata, O., Herzig, R., Valis, M. Tags: Original Articles Source Type: research

Are Inflammatory Biomarkers Increased in Varicose Vein Blood?
Conclusions: Blood drawn from the site of varicose veins appears to have significantly increased concentrations of IL-6, IL-8, and MCP-1 when compared to the same patient’s arm blood. This supports the hypothesis that inflammation is activated from the tissues drained by the varicose veins. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Lattimer, C. R., Kalodiki, E., Geroulakos, G., Hoppensteadt, D., Fareed, J. Tags: Original Articles Source Type: research

Four-Group Classification Based on Fibrinogen Level and Fibrin Polymerization Associated With Postoperative Bleeding in Cardiac Surgery
Fibrinogen and fibrin formation have a key role in perioperative hemostasis. The aim of this study is to examine the association of postoperative hemostasis with a combined evaluation of the fibrinogen level and fibrin polymerization in cardiac surgery. We retrospectively classified 215 consecutive cardiac surgery patients into 4 groups (Fuji-san classification) that were divided by fibrinogen level <150 mg/dL (ie, hypofibrinogenemia) and fibrinogen thromboelastometry value at 10 minutes with rotational thromboelastometry <6 mm (ie, low fibrin polymerization) at the warming of cardiopulmonary bypass. Four groups resu...
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Kawashima, S., Suzuki, Y., Sato, T., Kikura, M., Katoh, T., Sato, S. Tags: Original Articles Source Type: research

Intraoperative Hydroxyethyl Starch and its Effects on Different Fibrinogen Measurements
Conclusion: Despite providing different fibrinogen concentration values at baseline, the relative decrease in fibrinogen concentration after HES infusion was comparable among the 3 tests. In contrast, fibrin-based clot quality was more affected than fibrinogen concentration tests by HES infusion. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Winstedt, D., Solomon, C., Hillarp, A., Lundahl, T., Schött, U. Tags: Original Articles Source Type: research

Plasma D-Dimer as a Useful Marker Predicts Severity of Atherosclerotic Lesion and Short-Term Outcome in Patients With Coronary Artery Disease
Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed to evaluate whether plasma d-dimer levels could predict subsequent major clinical events in patients with coronary artery disease (CAD). First, 2209 angiographic-proven patients with CAD were consecutively enrolled. Then, all patients were subjected to follow up for an average of 18 months (ranged from 14 to 1037 days). The relationships of the plasma d-dimer with the severity of CAD and future clinical outcomes were evaluated. We found that plasma d-dimer was higher in patients with ...
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Gong, P., Yang, S.-H., Li, S., Luo, S.-H., Zeng, R.-X., Zhang, Y., Guo, Y.-L., Zhu, C.-G., Xu, R.-X., Li, J.-J. Tags: Original Articles Source Type: research

Evaluation of VTE Prophylaxis in an Educational Hospital: Comparison Between the Institutional Guideline (Caprini 2006) and the ACCP Guideline (Ninth Edition)
Venous thromboembolism (VTE) is the most common preventable cause of hospital death; the burden of VTE includes the management of the acute event (deep vein thrombosis [DVT]/pulmonary embolism) and the chronic subsequents such as postthrombotic syndrome and recurrent DVT. All experts agree that despite the abundance of knowledge available on VTE and how to prevent it, it is still underused, and since the first step in prophylaxis is to identify those who are at high risk of VTE, several risk assessment models have been developed to identify these patients and provide appropriate prophylaxis. In our study, the institutional...
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Gharaibeh, L., Albsoul-Younes, A., Younes, N. Tags: Original Articles Source Type: research

Economic Analysis Comparing Dalteparin to Vitamin K Antagonists to Prevent Recurrent Venous Thromboembolism in Patients With Cancer Having Renal Impairment
Conclusion: Secondary prophylaxis with dalteparin is a cost-effective alternative to VKA for the prevention of recurrent VTE in patients with cancer. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Dranitsaris, G., Shane, L., Burgers, L., Woodruff, S. Tags: Original Articles Source Type: research

Direct Oral Anticoagulants for the Management of Thromboembolic Disorders: The Importance of Adherence and Persistence in Achieving Beneficial Outcomes
Anticoagulation therapy is central to the management of thromboembolic disorders, and the use of direct oral anticoagulants offers several advantages over standard therapy with parenteral heparins and vitamin K antagonists. In phase III clinical trials, the direct oral anticoagulants (given once or twice daily) all demonstrated favorable benefit–risk profiles compared with conventional standard therapy for the treatment and secondary prevention of venous thromboembolism and for stroke prevention in patients with nonvalvular atrial fibrillation. In clinical practice, many factors may influence overall clinical outcome...
Source: Clinical and Applied Thrombosis/Hemostasis - August 29, 2016 Category: Hematology Authors: Amin, A., Marrs, J. C. Tags: Review Source Type: research

In Vivo Anticoagulant and Thrombolytic Activities of a Fibrinolytic Serine Protease (Brevithrombolase) With the k-Carrageenan-Induced Rat Tail Thrombosis Model
In the present study, in vivo thrombolysis efficiency of Brevithrombolase, a nontoxic fibrinolytic enzyme purified from Brevibacillus brevis strain FF02B, was affirmed by significant inhibition of thrombus formation in the k-carrageenan-induced rat tail, in a dose-dependent manner. Brevithrombolase at a dose of 600 µg/kg showed an efficacy that was comparable to streptokinase and plasmin, in dissolving in vivo thrombus of k-carrageenan-treated rats under identical conditions. The in vivo anticoagulant property of Brevithrombolase was demonstrated by its prolongation of activated partial thromboplastin time, prothromb...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Majumdar, S., Chattopadhyay, P., Mukherjee, A. K. Tags: Original Articles Source Type: research

Cerebral Thrombotic Complications Related to L-Asparaginase Treatment for Acute Lymphoblastic Leukemia: Retrospective Review of 10 Cases
l-Asparaginase is a potent antileukemia agent and an essential part of treatment protocols for acute lymphoblastic leukemia. However, toxicity limits dose escalation, especially in adults. This includes a significant risk of thrombosis, which remains an important source of avoidable morbidity and mortality. Here, we provide a detailed report of 10 cases of cerebral thrombotic complications that occurred over a 5-year period at 4 large tertiary referral hospitals. To our knowledge, this is the first report of this type in the published literature. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Eden, D., Hipkins, R., Bradbury, C. A. Tags: Original Articles Source Type: research

Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population
This study is to investigate the relationship between genetic polymorphisms and the risk of CAD and to evaluate their potential interactions. A total of 237 patients with CAD and 101 controls were genotyped. The association of the polymorphism with the risk of CAD varied among the ethnic groups. Moreover, the concomitant presence of both CETP B1 and eNOS 4a alleles significantly increased the risk of CAD in the Malay group (OR = 33.8, P < .001) and the Indian group (OR = 10.9, P = .031) but not in the Chinese group. This study has identified a novel ethnic-specific gene–gene interaction and suggested that the comb...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Chu, W. C., Aziz, A. F. A., Nordin, A. J., Cheah, Y. K. Tags: Original Articles Source Type: research

Platelet Aggregation Study in Patients With Hemoglobin E{beta} Thalassemia in India
Hemoglobin Eβ thalassemia is a major public health problem in India, especially in the state of West Bengal. Various thromboembolic events are common, especially in splenectomized patients. Platelet hyperactivity most likely plays a pathogenetic role. To investigate the role of platelets in hypercoagulability, platelet aggregation tests were undertaken in the present study. Platelet-rich plasma from 30 patients with Eβ thalassemia (15 splenectomized and 15 nonsplenectomized) were studied and compared with 15 healthy participants. The 4 agonists used were adenosine 5-diphosphate, adrenaline (epinephrine), collagen...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Ghosal, T., Dolai, T. K., Mandal, P. K., Karthik, S., Bandyopadhyay, A. Tags: Original Articles Source Type: research

Dehydration as a Possible Cause of Monthly Variation in the Incidence of Venous Thromboembolism
Conclusions: The current study demonstrates that occurrence of VTE exhibits monthly variation also existing in patients with provoked events and even in those with cancer. Dehydration is suggested as a potential explanation to the month-related variation in incidence of VTE. (Source: Clinical and Applied Thrombosis/Hemostasis)
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Elias, S., Hoffman, R., Saharov, G., Brenner, B., Nadir, Y. Tags: Original Articles Source Type: research

Thromboprophylaxis and Outcomes for Total Joint Arthroplasty in Congenital Bleeding Disorders: A Single-Center Experience
Total joint arthroplasty (TJA) improves the quality of life for patients with end-stage osteoarthritis but is associated with an increased risk of venous thromboembolism (VTE), thus pharmacologic thromboprophylaxis is recommended for most patients. Patients with congenital bleeding disorders may develop severe arthropathies due to repeated hemarthroses and derive similar benefit from TJA as the general population. No guidelines for pharmacologic thromboprophylaxis in this population exist, however, as the risks and benefits are not well defined. We undertook the current study to assess the safety and efficacy of pharmacolo...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Holderness, B. M., Goto, Y., McKernan, L., Bernini, P., Ornstein, D. L. Tags: Original Articles Source Type: research

Plasma Thrombin Generation and Sensitivity to Activated Protein C Among Patients With Myeloma and Monoclonal Gammopathy of Undetermined Significance
The etiology of the prothrombotic state in myeloma has yet to be definitively characterized. Similarly, while recent evidence suggests that patients with monoclonal gammopathy of undetermined significance (MGUS) may also be at increased risk of thrombosis, the magnitude and the etiology of this risk have also yet to be defined. The present study aims to characterize patterns of plasma thrombin generation and sensitivity to the anticoagulant activity of activated protein C (APC) at the time of initial diagnosis of myeloma and in response to therapy in comparison to that observed among patients with MGUS and matched, healthy...
Source: Clinical and Applied Thrombosis/Hemostasis - August 3, 2016 Category: Hematology Authors: Crowley, M. P., Kevane, B., OShea, S. I., Quinn, S., Egan, K., Gilligan, O. M., Ni. Ainle, F. Tags: Original Articles Source Type: research