Cerebral Thrombotic Complications Related to L-Asparaginase Treatment for Acute Lymphoblastic Leukemia: Retrospective Review of 10 Cases
l-Asparaginase is a potent antileukemia agent and an essential part of treatment protocols for acute lymphoblastic leukemia. However, toxicity limits dose escalation, especially in adults. This includes a significant risk of thrombosis, which remains an important source of avoidable morbidity and mortality. Here, we provide a detailed report of 10 cases of cerebral thrombotic complications that occurred over a 5-year period at 4 large tertiary referral hospitals. To our knowledge, this is the first report of this type in the published literature.
Source: Clinical and Applied Thrombosis/Hemostasis - Category: Hematology Authors: Eden, D., Hipkins, R., Bradbury, C. A. Tags: Original Articles Source Type: research
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