Effects of Fibrinogen Concentrate on Thrombin Generation, Thromboelastometry Parameters, and Laboratory Coagulation Testing in a 24-Hour Porcine Trauma Model

Conclusion:
This study suggests that, in trauma, fibrinogen supplementation may shorten some measurements of the speed of coagulation initiation and produce a short-lived increase in endogenous thrombin potential, potentially through increased clotting substrate availability. Approximately 12 and 24 hours after starting fibrinogen concentrate/saline infusion, all parameters measured in this study were comparable in the 2 study groups.

Source: Clinical and Applied Thrombosis/Hemostasis - October 6, 2016 Category: Hematology Authors: Zentai, C., Solomon, C., van der Meijden, P. E. J., Spronk, H. M. H., Schnabel, J., Rossaint, R., Grottke, O. Tags: Original Articles Source Type: research