Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 1, 2017 Category: Cardiology Source Type: research
Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells
Oxidized low-density lipoprotein (ox-LDL) has been reported to induce apoptosis of endothelial cells (ECs) and contribute to the progression of atherosclerosis. Kaempferol has been shown to possess anti-atherosclerotic effect. The aim of the present study was to evaluate the effect of kaempferol on ox-LDL-induced apoptosis of human umbilical vein endothelial cells (HUVECs) and its possible molecular basis. The results showed that kaempferol alleviated ox-LDL-induced apoptosis. Kaempferol increased the ratio of LC3-II/I and beclin-1 level in ox-LDL-induced HUVECs. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 9, 2017 Category: Cardiology Authors: Jianbo Che, Bing Liang, Yuan Zhang, Yi Wang, Jianyu Tang, Gongning Shi Tags: Original Article Source Type: research
Aortic Fibromuscular Dysplasia Complicated by Dissection: A Case Report and Review of Literature
We describe the case of a 40-year-old woman diagnosed with aortic FMD complicated by the occurrence of a type A aortic dissection. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 8, 2017 Category: Cardiology Authors: Takashi Tasaki, Kazuhito Hatanaka, Mari Kirishima, Shun Ohnishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Sohsuke Yamada, Michiyo Higashi, Akihide Tanimoto Tags: Case Report Source Type: research
Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an immunocompetent Chinese elderly woman
Primary cardiac lymphoma is a rare type of extranodal lymphoma that involves only heart and/or pericardium. It is usually observed in immunodeficient people. However, immunocompetent patients may also suffer from this disease. Most primary cardiac lymphomas are of B-cell lineage, and they usually present as diffuse large B-cell lymphoma (DLBCL). Diffuse large B-cell lymphoma with concurrently high MYC and BCL2 expression, which is named as double- expressor lymphoma (DEL), is a rare subtype of DLBCL. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 4, 2017 Category: Cardiology Authors: Ying Wan, Du He, Yunxia Ye, Wenyan Zhang, Sha Zhao, Yanhong Long, Min Chen, Can K üçük Source Type: research
Four New Cases of Pediatric Thoracic Aortic Aneurysm (TAA) with Review of the Molecular Genetic Basis, Utilizing the Newly Published Consensus Nomenclature
The majority of thoracic aortic aneurysms (TAA) in the pediatric population are due to post repair etiology (iatrogenic). Although rare, underlying inheritable disease and congenital cardiac anomalies represent the most common non-iatrogenic cause of TAA among patients in this age group (1 –21years of age). Herein, we present a case series of aortic aneurysms with varying underlying etiology. We discuss the molecular genetic basis of these syndromes in conjunction with the radiological findings and histological description utilizing the newly published consensus criteria article. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 28, 2017 Category: Cardiology Authors: Shriprasad Deshpande, Adina Alazraki, Nasim Khoshnam, Diana Kantarovich, Pooya Hoseinzadeh, Camden Hebson, Ajay Bhatia, Lauren Schaffer, Elana Maccou, Bahig M. Shehata Tags: Original Article Source Type: research
Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure
Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGF β1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 17, 2017 Category: Cardiology Authors: Kevin J. Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J. Aronovitz, Emily E. Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M. Blanton, S. Paul Oh, Richard H. Karas, Navin K. Kapur Tags: Original Article Source Type: research
Reduced Activin Receptor Like-Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure
Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGF β1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 17, 2017 Category: Cardiology Authors: Kevin J. Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J. Aronovitz, Emily E. Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M. Blanton, S. Paul Oh, Richard H. Karas, Navin K. Kapur Tags: Original Article Source Type: research
Increased β-Catenin Accumulation and Nuclear Translocation are Associated with Concentric Hypertrophy in Cardiomyocytes
Defective Wnt/ β-Catenin signaling, activated under various pathological conditions can result in cardiac and vascular abnormalities. In the present study, the possible role of β-catenin over expression during cardiac hypertrophy was investigated. 10 samples from hearts of human patients with acute infarction, g ranulation tissue from 20 patients and 10 from normal ones were collected in order to investigate roles of β-catenin in cardiac hypertrophy. H9c2 cardiomyoblast cells and Wistar rat primary neonatal cardiomyocytes were overexpressed with β-catenin. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 12, 2017 Category: Cardiology Authors: Cheng-Yu Lee, Wei Wen Kuo, Rathinasamy Baskaran, Cecilia Hsuan Day, Pei Ying Pai, Chao Hung Lai, Yu-Feng Chen, Ray-Jade Chen, Viswanadha Vijaya Padma, Chih Yang Huang Source Type: research
Intimal sarcoma of the pulmonary trunk showing broad intimal extension and focal chondrosarcomatous differentiation: an autopsy case
We report an autopsy case of intimal sarcoma arising in the pulmonary artery with focal chondrosarcomatous differentiation. A 77-year-old woman presented with a thrombosis-like mass in the pulmonary trunk, and underwent endarterectomy. Macroscopically, solid and myxomatous tumor expanded to the pulmonary valve and bilateral main pulmonary arteries. Microscopically, the tumor comprised atypical spindle cells proliferating in a fascicular fashion, as well as occasional bizarre multinucleated cells, within a myxomatous stroma. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 8, 2017 Category: Cardiology Authors: Kosuke Miyai, Hiroaki Takeo, Susumu Matsukuma Tags: Case report Source Type: research
Hereditary Multiple Exostoses as a Novel Cause of Bilateral Popliteal Artery Aneurysms in the Elderly
We report an autopsy study of an elderly man who presented with bilateral popliteal artery pseudoaneurysms in the setting of HME at age 81. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 7, 2017 Category: Cardiology Authors: Eliza J. Ferrari, Rory K. Crotty, Katharina Eikermann-Haerter, James R. Stone Source Type: research
Complete step section microscopic study of a Swan –Ganz catheter-related pulmonary artery rupture: a frequently lethal complication that to our knowledge has not had a comprehensive microscopic examination: case report and literature review
Introduced in 1970, the Swan –Ganz catheter (SGC) soon became widely used because of its unique usefulness in managing intensive care patients. Unfortunately, SGC usage was complicated by pulmonary artery rupture (PAR) with a 50% mortality rate that led to a near banning of the SCG in the late 1980s. Increasing knowledge and decreasing incidence of SGC-related PARs (SGPARs) led to the current feeling that the present SGPAR incidence is now low enough to tolerate given the lives saved by SGC usage. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 4, 2017 Category: Cardiology Authors: Ya Xu, L Clarke Stout Tags: Clinical Case Report Source Type: research
Extranodal Rosai –Dorfman disease arising in the heart: clinical course and review of literature
Rosai –Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a nonmalignant disease of unknown etiology. It may present as bilateral, massive, painless cervical lymphadenopathy; however, one third of the cases have extranodal involvement. Extranodal sites include soft tissue, skin, upper respiratory and gastrointestinal tracts, and central nervous system, with head and neck being the most common. Here we report a rare case of intracardiac RDD in a 46-year-old, African–American female who presented with worsening shortness of breath and fatigue for 7 weeks. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 4, 2017 Category: Cardiology Authors: Amin Heidarian, Ayesha Anwar, M.A. Haseeb, Raavi Gupta Tags: Clinical Case Report Source Type: research
Complete Step Section Microscopic Study of a Swan-Ganz Catheter Related Pulmonary Artery Rupture: A frequently lethal complication that to our knowledge has not had a comprehensive microscopic examination: Case Report and Literature Review
Introduced in 1970 the Swan-Ganz catheter (SGC) soon became widely used because of its unique usefulness in managing intensive care patients. Unfortunately SGC usage was complicated by pulmonary artery rupture (PAR) with a 50% mortality rate that led to a near banning of the SCG in the late 1980s. Increasing knowledge and decreasing incidence of SGC related PARs (SGPAR)s led to the current feeling that the present SGPAR incidence is now low enough to tolerate, given the lives saved by SGC usage. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 4, 2017 Category: Cardiology Authors: Ya Xu, L Clarke Stout Source Type: research
Ultrastructural aspects of vacuolar degeneration of cardiomyocytes in human endomyocardial biopsies
Vacuolar degeneration of cardiomyocytes is a histological finding commonly encountered during routine light microscopic examination of human endomyocardial biopsy specimens. The vacuoles appear as intracellular clear areas lacking myofibers. By itself, this finding has little diagnostic value, but may have important clinical implications when the vacuolar contents are of etiological significance (e.g., accumulation of abnormal metabolites), and the clinical importance is increased when the disease is treatable. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 4, 2017 Category: Cardiology Authors: Genzou Takemura, Hiromitsu Kanamori, Hideshi Okada, Akiko Tsujimoto, Nagisa Miyazaki, Chihiro Takada, Yasuaki Hotta, Yoshiki Takatsu, Takako Fujiwara, Hisayoshi Fujiwara Source Type: research
Extranodal Rosai-Dorfman disease arising in the heart: clinical course and review of literature
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a non-malignant disease of unknown etiology. It may present as bilateral, massive, painless cervical lymphadenopathy; however, one-third of the cases have extranodal involvement. Extranodal sites include soft tissue, skin, upper respiratory and gastrointestinal tracts, central nervous system, and head and neck being the most common. Here we report a rare case of intracardiac RDD in a 46-year-old, African-American female who presented with worsening shortness of breath and fatigue for 7weeks. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 4, 2017 Category: Cardiology Authors: Amin Heidarian, Ayesha Anwar, M.A. Haseeb, Raavi Gupta Source Type: research
