Reduced Activin Receptor Like-Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure

Activin receptor-like kinase 1 (ALK1) mediates signaling via the transforming growth factor beta-1 (TGF β1), a pro-fibrogenic cytokine. No studies have defined a role for ALK1 in heart failure.

Source: Cardiovascular Pathology - July 17, 2017 Category: Cardiology Authors: Kevin J. Morine, Xiaoying Qiao, Vikram Paruchuri, Mark J. Aronovitz, Emily E. Mackey, Lyanne Buiten, Jonathan Levine, Keshan Ughreja, Prerna Nepali, Robert M. Blanton, S. Paul Oh, Richard H. Karas, Navin K. Kapur Tags: Original Article Source Type: research