Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 1, 2017 Category: Cardiology Source Type: research
Molecular Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy
The article is based on work presented in the Distinguished Achievement Award lecture at the Society for Cardiovascular Pathology meeting in Seattle, WA in March, 2016. It reviews our current understanding of mechanisms responsible for a highly arrhythmogenic, non-ischemic cardiomyopathy. It highlights the armamentarium of powerful methods available to the experimental pathologist in efforts to define how complex cardiovascular diseases work. It concludes with acknowledgment of the need for a far more detailed approach as to how we categorize human disease, a task for which pathologists are especially well positioned. (Sou...
Source: Cardiovascular Pathology - February 25, 2017 Category: Cardiology Authors: Jeffrey E. Saffitz Source Type: research
The content of collagen type II in human arteries is correlated with the stage of atherosclerosis and calcification foci
The signature processes during atherosclerosis development are arterial calcification and accumulation in the arterial walls of proteins that are specific to bone and cartilage, e.g. collagen type II. The purpose of this study was to characterize localization of collagen type II and quantify its content in human arteries. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 13, 2017 Category: Cardiology Authors: Aleksandra Kuzan, Agnieszka Chwi łkowska, Celina Pezowicz, Wojciech Witkiewicz, Andrzej Gamian, Krzysztof Maksymowicz, Magdalena Kobielarz Source Type: research
Cardiac myxoma: report of a case with bizarre histiocytic infiltration
We report a case of cardiac myxoma with highly atypical histiocytic cells located superficially within the myxoma and mimicking malignant cells. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 12, 2017 Category: Cardiology Authors: Deepika Savant, Leonard Kahn Tags: Case Report Source Type: research
Cardiac Myxoma - Report of a Case with Bizarre Histiocytic Infiltration
We report a case of cardiac myxoma with highly atypical histiocytic cells located superficially within th e myxoma and mimicking malignant cells. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 12, 2017 Category: Cardiology Authors: Deepika Savant, Leonard Kahn Source Type: research
Atrial angioleiomyoma with myopericytoma-like features: A case report
A 66year-old female patient was referred to our hospital for resection of a right atrial mass. Four months earlier she had suffered an acute cerebrovascular accident due to occlusion of the sylvian segment of the right middle cerebral artery from atheromatous tight stenosis in the right internal carotid artery. Later, investigations with transthoracic and transesophageal echocardiography revealed a 3.4cm right atrial mass, that was resected surgically. Microscopic evaluation revealed a well circumscribed nodular tumor, located within the interatrial septum, and corresponding to an angioleiomyoma (ALM). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 7, 2017 Category: Cardiology Authors: Hussein Nassereddine, Aur élie Cazes, Constance Verdonk, Benjamin Assous, Raphael Dautry, Patrick Nataf, Michel Wassef, Lydia Deschamps Source Type: research
Fatal fungal endocarditis by Aspergillus udagawae: An emerging cause of invasive aspergillosis
We present the first reported case of infectious endocarditis caused by A. udagawae. An awareness of this newly described Aspergillus species is vital for further clarification. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 7, 2017 Category: Cardiology Authors: Atsuko Seki, Atsushi Yoshida, Yoko Matsuda, Mitsuhiro Kawada, Takashi Nishimura, Jun Tanaka, Yoshiki Misawa, Yuta Nakano, Ryoko Asami, Koji Chida, Ken Kikuchi, Tomio Arai Source Type: research
A congenital diverticulum of the left ventricular apex manifested by stroke and recurrent ventricular tachycardia
Left ventricular (LV) outpouchings include acquired pathologies comprising ventricular aneurysm or pseudoaneurysm and congenital abnormality ventricular diverticulum (CVD) [1 –3]. CVD is a rare cardiac malformation consisting of a localized protrusion from the free wall of the LV. Although it is often associated with other cardiac and extracardiac congenital anomalies, it may also present alone, as an incidental finding in adult patients. Although very rare, CVD may be associated with significant morbidity and even mortality. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 2, 2017 Category: Cardiology Authors: Gabriela Dost álová, Tomáš Paleček, Petr Kuchynka, Štěpán Havránek, Martin Mašek, Zuzana Hlubocká, Debora Karetová, Dan Wichterle, Jaroslava Dušková, Jaroslav Lindner, Aleš Linhart Source Type: research
Multiple Myocardial Abscesses secondary to Late Stent Infection
A 53-year-old woman presented to our hospital with dizziness and low grade fever. She underwent percutaneous coronary intervention to the obtuse marginal artery with a drug-eluting stent 20-months prior to this presentation. Physical examination was remarkable for bradycardia. Electrocardiogram showed a junctional rhythm with heart rate of 35bpm. Blood and urine cultures were negative. Despite successful urgent pacemaker placement, she had cardiac arrest the following day with unsuccessful cardiopulmonary resuscitation attempt. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - February 1, 2017 Category: Cardiology Authors: Ayman Elbadawi, Marwan Saad, Islam Y. Elgendy, Aniqa Zafar, Ming-Yan Chow Source Type: research
Abdominal aortic aneurysm —an independent disease to atherosclerosis?
Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute toward disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that comorbidity is usually between ~25% and 55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Most recent epidemiological, clinical, and biological evidence suggests that the two pathologies are more distinct than traditionally though...
Source: Cardiovascular Pathology - January 28, 2017 Category: Cardiology Authors: Bradley J. Toghill, Athanasios Saratzis, Matthew J. Bown Tags: Original Article Source Type: research
Abdominal aortic aneurysm – an independent disease to atherosclerosis?
Atherosclerosis and abdominal aortic aneurysms (AAAs) are multifactorial and polygenic diseases with known environmental and genetic risk factors that contribute towards disease development. Atherosclerosis represents an important independent risk factor for AAA, as people with AAA often have atherosclerosis. Studies have shown that co-morbidity is usually between~25 –55%, but it is still not fully known whether this association is causal or a result of common shared risk profiles. Most recent epidemiological, clinical and biological evidence suggests that the two pathologies are more distinct than traditionally thought....
Source: Cardiovascular Pathology - January 28, 2017 Category: Cardiology Authors: Bradley J Toghill, Athanasios Saratzis, Matthew J Bown Tags: Original Article Source Type: research
Sudden cardiac death and sarcoidosis of the heart in a young patient
Sarcoidosis is a granulomatous disease of unknown aetiology affecting any organ, microscopically characterized by non caseating granulomata [1 –4]. Cardiac involvement in sarcoidosis was reported in 2–5% of patients with systemic sarcoidosis but both autopsy studies and modern cardiac imaging suggest that clinically manifest cases may represent just the tip of the iceberg in cardiac sarcoidosis [5]. It might be asymptomatic or manifest as dyspnoea, unexplained fatigue, arrhythmias, and sudden death. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 24, 2017 Category: Cardiology Authors: Jotterand Morgane, Grabherr Silke, Lobrinus Johannes Alexandre, Michaud Katarzyna Source Type: research
Vascular inflammation and media calcification are already present in early stages of chronic kidney disease
While patients with CKD have a high prevalence of classical coronary risk factors, there is increasing evidence that atherosclerosis is different in renal compared to non-renal patients. Therefore, the present study compares changes in different vessels obtained at cardiac surgery between patients with early and advanced CKD and non-renal control patients. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 22, 2017 Category: Cardiology Authors: Kerstin Benz, Ildiko Varga, Daniel Neureiter, Valentina Campean, Christoph Daniel, Christian Heim, Albrecht Reimann, Michael Weyand, Karl F. Hilgers, Kerstin Amann Source Type: research
Eosinophilic endomyocardial disease
We describe the case of a 58-year-old woman with a history of asthma found to have a left ventricular apical thrombus. Cardiac catheterization with endomyocardial biopsy was consistent with eosinophilic endomyocardial disease. The disease affects several organ systems and shares many features with more common conditions, making it a difficult diagnosis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 22, 2017 Category: Cardiology Authors: Victor Y Liu, Raymundo A Quintana-Quezada, L Maximilian Buja Source Type: research
Leukocytoclastic Vasculitis Associated with Endocarditis in a Patient with Transposition of the Great Arteries and Mechanical Valve Replacement
Immunological vascular phenomena can be the initial manifestation of bacterial infection and endocarditis. Here, we report a rare case of leukocytoclastic vasculitis without immune complexes or cryoglobulinemia in a patient with infective endocarditis, congenital heart disease and a prior mechanical valve replacement. The patient completely recovered following antibiotic therapy and skin lesions disappeared without immune suppression, which suggested infection-mediated vasculitis. While the treatment of leukocytoclastic vasculitis typically involves immunosuppressive therapy, the treatment for infection-mediated vasculitis...
Source: Cardiovascular Pathology - January 22, 2017 Category: Cardiology Authors: Christian Riehle, Gesine M. Scharf, Jan-Thorben Sieweke, Florian Zauner, Ulrike Flierl, Jens Treptau, Christos Zormpas, Jana Senf, Nicholas S. McCarty, Johann Bauersachs, Daniel G. Sedding, Mechthild Westhoff-Bleck Source Type: research
