Consensus documents – past, present, and future
We present these together in our first ever special issue [1] so pathologists from diverse backgrounds and with varying experience with these topics can readily find them in one place: (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 21, 2018 Category: Cardiology Authors: Michael A. Seidman Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 14, 2018 Category: Cardiology Source Type: research
Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 14, 2018 Category: Cardiology Source Type: research
Mesothelial/monocytic incidental cardiac excrescences (MICE): report of a case and review of literature with focus on pathogenesis
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a benign lesion composed of histiocytes and mesothelial cells, usually found during cardiac surgery. To date, no more than 50 cases are reported in literature and pathogenesis is still unclear, even if different theories have been proposed. Here we report a case of MICE encountered during aortic valve replacement with typical histological features and extensive immunohistochemical investigation. To date little information is available about the pathogenesis of MICE. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 10, 2018 Category: Cardiology Authors: Ilaria Girolami, A. Eccher, E. Gilioli, L. Novelli, G. Di Stefano, M. Brunelli, L. Cima Source Type: research
CD39 and CD73 in the aortic valve —biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization
The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis, and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ectonucleotidases, mainly ectonucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5 ’nucleotidase (CD73, e5NT). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: Ewa Kaniewska-Bednarczuk, Barbara Kutryb-Zajac, Padmini Sarathchandra, Iwona Pelikant-Malecka, Alicja Sielicka, Izabela Piotrowska, Ewa M. Slominska, Adrian H. Chester, Magdi H. Yacoub, Ryszard T. Smolenski Tags: Original Article Source Type: research
Intramural capillary hemangioma of gallbladder artery: age-related or treatment-induced change?
Capillary hemangiomas (HAs) are frequent vascular tumor. However, to our knowledge, there are few data on capillary HAs strictly located in the arterial wall [1]. We had recently the opportunity to detect a microscopic capillary HA located in the thickness of a gallbladder arterial wall. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: Adriana Handra-Luca Tags: Letter to the Editor Source Type: research
CD39 and CD73 in the aortic valve – biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization
The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ecto-nucleotidases, mainly ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5 ’nucleotidase (CD73, e5NT).Objective and Methods.We investigated the localization of CD39 and CD73 proteins in human non-calcified and calcified aortic valves using immunohistochemistry together with analysis of NTPDases and e5NT activities in aortic va...
Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: Ewa Kaniewska-Bednarczuk, Barbara Kutryb-Zajac, Padmini Sarathchandra, Iwona Pelikant-Malecka, Alicja Sielicka, Izabela Piotrowska, Ewa M. Slomi ńska, Adrian H. Chester, Magdi H. Yacoub, Ryszard T. Smolenski Source Type: research
Candida parapsilosis endocarditis in an intravenous drug abuser: An autopsy report
Candida parapsilosis is a rare cause of endocarditis, which is seen to affect the native.valves in patients who are known intravenous drug abusers or following contamination during surgery for prosthetic valves. We discuss a unique constellation of autopsy findings in a 35-year-old chronic opium abuser who presented with left sided weakness followed by low grade fever. He was diagnosed to have Candida parapsilosis native valve endocarditis with septic emboli involving the myocardial vessels, left middle cerebral artery, spleen and common iliac artery. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: Manoj Gopal Madakshira, Amanjit Bal, ShivaPrakash, Manish Rathi, Rajesh Vijayvergiya Source Type: research
Hemangioma of the artery
Intramural capillary hemangioma of gallbladder artery: age-related or treatment-induced change? (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: A Handra-Luca Source Type: research
Pathological evidence of adrenergic cardiac denervation in a patient with congestive heart failure
Autonomic dysfunction, with sympathetic hyperactivity and parasympathetic depression, is a key component of congestive heart failure (CHF) and a therapeutic target. Impaired autonomic modulation correlates inversely with survival, and an inverse correlation between chronotropic incompetence and exercise capacity has also been reported [1]. Finally, in patients with CHF, cardiac denervation is associated with sudden death [2]. All these findings justify further study of cardiac innervation. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 5, 2018 Category: Cardiology Authors: D Acanfora, G Casucci, MM Ciccone, P Scicchitano, T Lonobile, L Chiariello, R Maestri, C Pedone, V Provitera, M Nolano, R Antonelli Incalzi Tags: Case Report Source Type: research
Aortic valve replacement for aortic regurgitation associated with osteogenesis imperfecta
We report a successful case of aortic valve replacement for aortic regurgitation (AR) associated with OI. Patient was implanted with a mechanical valve and the postoperative course was uneventful. It is mandatory to carefully select t he appropriate timing for surgery. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 24, 2018 Category: Cardiology Authors: Keito Suzuki, Akira Sezai, Satoshi Unosawa, Hiroyuki Hao, Masashi Tanaka Tags: Case Report Source Type: research
Achromobacter endocarditis in native cardiac valves — an autopsy case report and review of the literature
We present an autopsy report of Achromobacter endocarditis involving the native valves in a woman with end-stage renal disease (ESRD) on hemodialysis (HD). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 22, 2018 Category: Cardiology Authors: Rong Xia, Caitlin Otto, Jianying Zeng, Amir Momeni-Boroujeni, Joshua Kagan, Katharine Meleney, Jenny Libien Tags: Clinical Case Report Source Type: research
Achromobacter endocarditis in native cardiac valves – an autopsy case report and review of the literature
We present an autopsy report of Achromobacter endocarditis involving the native valves in a woman with end-stage renal disease (ESRD) on hemodialysis (HD). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 22, 2018 Category: Cardiology Authors: Rong Xia, Caitlin Otto, Jianying Zeng, Amir Momeni-Boroujeni, Joshua Kagan, Katharine Meleney, Jenny Libien Tags: Case Report Source Type: research
Coronary pathology of inherited generalized arterial calcification of infancy: a case report
Generalized arterial calcification of infancy (GACI), or idiopathic infantile arterial calcification, is a rare autosomal-recessive disease recognized aAs an inherited disorder characterized by severe pathologic calcification of large- and medium-sized arteries accompanied by smooth muscle cell (SMC) hyperplasia leading to vascular obstruction [1]. The prognosis is extremely poor, with 85% of affected infants dying within the first 6 months of life. Loss-of-function mutations in the ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) gene is recognized as the main defect associated with GACI [1]. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 18, 2018 Category: Cardiology Authors: Duccio Federici, Sho Torii, Matteo Ciuffreda, Lorenzo Galletti, Luca Lorini, Ezio Bonanomi, Andrea Gianatti, Maria Iascone, Joohyung Park, Liang Guo, Maria E. Romero, Frank D. Kolodgie, Giulio Guagliumi, Renu Virmani Tags: Clinical Case Report Source Type: research
Method for preclinical pathology evaluation and analysis of cardiovascular implantable electronic device implant sites
Cardiovascular implantable electronic devices (CIEDs) typically incorporate leads that directly contact the endocardium. Post-explant pathology evaluation of formalin-fixed CIED lead implant sites and downstream organs (i.e., lungs) can provide useful safety data to the US Food and Drug Administration; however, current regulatory guidelines do not mandate how the safety data are collected. In this paper we outline a protocol for preclinical pathology evaluation of leads associated with CIEDs, which includes formalin fixation of the heart and lungs, gross evaluation, and qualitative and quantitative histologic evaluation. (...
Source: Cardiovascular Pathology - May 18, 2018 Category: Cardiology Authors: Staci L. Jessen, Maureen T. O'Brien, Trevor W. Lancon, Harrison R. Smith, Leslie L. Suarez, Matthew D. Wilcox, Matthew Miller, Brad R. Weeks, Fred J. Clubb Tags: Original Article Source Type: research
