Reduced epicardial vagal nerve density and impaired vagal control in a rat myocardial infarction –heart failure model
Autonomic remodeling, characterized by sympathetic activation and vagal withdrawal, contributes to heart failure (HF) progression. However, the exact mechanism(s) responsible for vagal withdrawal in HF remain(s) unclear, and whether HF causes epicardial autonomic nerve remodeling is unknown. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 22, 2016 Category: Cardiology Authors: Matthew S. Delfiner, John Siano, Ying Li, Eduard I. Dedkov, Youhua Zhang Tags: Original Article Source Type: research
Reduced Epicardial Vagal Nerve Density and Impaired Vagal Control in a Rat Myocardial Infarction-Heart Failure Model
Autonomic remodeling, characterized by sympathetic activation and vagal withdrawal, contributes to heart failure (HF) progression. However, the exact mechanism(s) responsible for vagal withdrawal in HF remain(s) unclear, and whether HF causes epicardial autonomic nerve remodeling is unknown. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 22, 2016 Category: Cardiology Authors: Matthew S. Delfiner, John Siano, Ying Li, Eduard I. Dedkov, Youhua Zhang Source Type: research
Woven coronary artery anomaly presenting as sudden cardiac death
Woven coronary artery is a rare anomaly characterized by thin channels arising from the coronary artery and reanastomosing at the distal arterial segment. To our knowledge, no data are available currently on the histologic structure of the woven segment. A 39-year-old man presented with sudden atypical chest pain while he was practicing cycling. During the transfer of the patient to the hospital he suffered cardiac arrest. After 50 min of cardiopulmonary resuscitation, the patient could not return to sinus rhythm and died. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 19, 2016 Category: Cardiology Authors: Jos é-Fernando Val-Bernal, Séfora Malaxetxebarria, Irene González-Rodilla, Miguel Salas-García Tags: Case Report Source Type: research
Altered protein levels in the isolated extracellular matrix of failing human hearts with dilated cardiomyopathy
Dilated cardiomyopathy is associated with extensive pathological cardiac remodeling and involves numerous changes in the protein expression profile of the extracellular matrix of the heart. We obtained 7 human, end-stage, failing hearts with dilated cardiomyopathy (DCM-failing) and 9 human, non-failing donor hearts and compared their extracellular matrix protein profiles. We first showed that the DCM-failing hearts had indeed undergone extensive remodeling of the left ventricle myocardium relative to non-failing hearts. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 14, 2016 Category: Cardiology Authors: Joshua L. DeAguero, Elizabeth N. McKown, Liwen Zhang, Jeremy Keirsey, Edgar G. Fischer, Von G. Samedi, Benjamin D. Canan, Ahmet Kilic, Paul M.L. Janssen, Dawn A. Delf ín Source Type: research
Fatal coronary sinus thrombosis due to hypercoagulability in Crohn's disease
A 27-year-old male, admitted to hospital for a psoas muscle abscess secondary to Crohn's disease, suddenly died while in hospital. A medicolegal autopsy showed coronary sinus thrombosis. Coronary sinus thrombosis is rare and is usually associated with invasive cardiac procedures. Coronary sinus thrombosis associated with Crohn's disease has not been reported. Autopsy examination of the coronary sinus is advocated, especially in individuals with hypercoagulable states. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 5, 2016 Category: Cardiology Authors: Janet Martin, Vidhya Nair, Allison Edgecombe Tags: Original Article Source Type: research
Right atrial ball thrombus after an intraatrial repair in a 3-year-old girl
We describe the case of a 3-year-old girl who presented with a large, mobile, ball mass in the right atrium on routine transthoracic echocardiography at one year after an intraatrial repair. Considering the risk of pulmonary embolization, emergent surgery was successfully performed to remove the mass, and histopathological examination revealed that it was a ball thrombus with a fibrin clot. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 5, 2016 Category: Cardiology Authors: Masato Kimura, Hisao Yaoita, Osam Adachi, Shigeo Kure Tags: Images in Cardiovascular Pathology Source Type: research
Atherosclerosis of aberrant arteries from the left gastric artery into the right intralobar pulmonary sequestration complicated by mycobacterial epithelioid cell granuloma
Vascular changes observed in intralobar pulmonary sequestration (PS) have been reported to be similar to those observed in pulmonary hypertension (PH). However, atherosclerosis in the pulmonary artery, which is one of the characteristic arterial changes of PH, has scarcely been reported in PS. Here, we report this unique manifestation in a 66-year-old man, in whom an intralobar PS fed by an aberrant artery branching from the left gastric artery had been identified 10 years earlier, and who was diagnosed with pneumonia after having symptoms of fever and cough. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 4, 2016 Category: Cardiology Authors: Hirotsugu Hashimoto, Masahiro Yanagiya, Masashi Kusakabe, Atsushi Kurata, Sayaka Ohara, Yoshio Suzuki, Jun Matsumoto, Hajime Horiuchi Source Type: research
Studies on postmortem heart weight and missing citation — a response to Dr. Wingren
Wingren has correctly addressed that the interesting study by him and Ottosson on postmortem heart weight [1] was not cited in our study on the same topic [2]. That should not have happened, and it was by all means not deliberate. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 29, 2016 Category: Cardiology Authors: Ivar Skj åk Nordrum, Ane Christine Skurdal Tags: Images in Cardiovascular Pathology Source Type: research
Studies on postmortem heart weight and missing citation – a response to Dr. Wingren
Wingren has correctly addressed that the interesting study by him and Ottosson on postmortem heart weight (1) was not cited in our study on the same topic (2). That should not have happened, and it was by all means not deliberate. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 29, 2016 Category: Cardiology Authors: Ivar Skj åk Nordrum, Ane Christine Skurdal Tags: Images in Cardiovascular Pathology Source Type: research
Addressing the interplay between observed and modelled data in a “A retrospective study of postmortem heart weight in an adult Norwegian population”
It was with interest we read the article by Skurdal and Nordrum published in the journal during July 2016 [1]. In the article the authors model heart weight using linear regression in a population of 692 cases subjected to either a forensic or a medical autopsy. Reference heart weights are presented separately in men and women and in steps of 5 kg between 40 to 130 kg. To motivate their study the authors state that most previous research on the subject is aged. However, the authors have failed to recognize a study of ours published in 2015 [2]. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 26, 2016 Category: Cardiology Authors: Carl Johan Wingren Source Type: research
The concept of double inlet-double outlet right ventricle: a distinct congenital heart disease
The aim of this study was to estimate the incidence and to analyze the anatomy of double inlet-double outlet right ventricle complex and its associated cardiac anomalies in our autopsy series. Among the 1640 hearts with congenital heart disease of our Anatomical Collection, we reviewed the specimens with double inlet-double outlet right ventricle, according to the sequential-segmental analysis, identifying associated cardiac anomalies and examining lung histology to assess the presence of pulmonary vascular disease. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 24, 2016 Category: Cardiology Authors: Veronica Spadotto, Carla Frescura, Siew Yen Ho, Gaetano Thiene Tags: Original Article Source Type: research
The Concept of Double Inlet- Double Outlet Right Ventricle: A Distinct Congenital Heart Disease
The aim of this study was to estimate the incidence and to analyze the anatomy of double inlet-double outlet right ventricle complex and its associated cardiac anomalies in our autopsy series. Among the 1640 hearts with congenital heart disease of our Anatomical Collection, we reviewed the specimens with double inlet-double outlet right ventricle, according to the sequential-segmental analysis, identifying associated cardiac anomalies and examining lung histology to assess the presence of pulmonary vascular disease. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 24, 2016 Category: Cardiology Authors: Veronica Spadotto, Carla Frescura, Siew Yen Ho, Gaetano Thiene Source Type: research
An Obesity Paradox: An Inverse Correlation between Body Mass Index and Atherosclerosis of the Aorta
Morbid obesity generally has been associated with higher morbidity and mortality for a variety of diseases. However, a number of exceptions to this have been reported and referred to as the “obesity paradox.” The purpose of the present study was to obtain objective data on aortic atherosclerosis and its relationship to body mass index (BMI, kg/m2), based on autopsy findings in a large cohort of overweight and obese decedents. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 12, 2016 Category: Cardiology Authors: Sergey V. Brodsky, Rolf F. Barth, Xiaokui Mo, Vedat Yildiz, Patricia Allenby, Iouri Ivanov, Stephen Moore, Charles L. Hitchcock, Stephen Smith, Taha Sachak, Keluo Yao, Matthew Ball, Kelly Rosborough, Zachary Olson, Micah Kiehl, Navin Muni, Renu Virmani Source Type: research
Bifid cardiac apex and high take off: an unusual association in a case of Sudden Death
We present the case of an 11-year old boy, with a positive family history for sudden cardiac death, who died while he was playing with his friends. An autopsy was performed and, on gross examination, bifid cardiac apex and high take off of right coronary artery were found. Furthermore, on histological examination signs of myo-pericarditis were observed. This is, at our knowledge, the first case in literature in which bifid cardiac apex is associated with a high take off of right coronary artery. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 7, 2016 Category: Cardiology Authors: Debora De Bartolo, Ester De Luca, Vincenzo Arena, Francesco Ausania, L. Maximilian Buja, Pietrantonio Ricci Source Type: research
Peristrut microhemorrhages: a possible cause of in-stent neoatherosclerosis?
In-stent neoatherosclerosis is characterized by the delayed appearance of markers of atheroma in the subintima, but the pathophysiology underlying this new disease entity remains unclear. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 28, 2016 Category: Cardiology Authors: Zaven Terzian, T. Christian Gasser, Francis Blackwell, Fabien Hyafil, Liliane Louedec, Catherine Deschildre, Walid Ghodbane, Richard Dorent, Antonino Nicoletti, Marion Morvan, Mohammed Nejjari, Laurent Feldman, Graciela Pavon-Djavid, Jean-Baptiste Michel Tags: Original Article Source Type: research
