Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during ageing
Changes in sensory and sympathetic innervation during diabetes mellitus (DM) can be a predictor of arrhythmias, silent myocardial ischemia and chronic heart failure, but knowledge about these changes is still unsatisfactorily. We analysed whether prolonged DM induces changes in density of sensory and sympathetic nerve terminals of rat's heart, and whether it contributes to cardiomyopathy during ageing. DM was induced by i/p injecting 55 mg/kg streptozotocin (STZ) to male Sprague-Dawley rats, while a control group received a citrate buffer. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 15, 2017 Category: Cardiology Authors: Marija Bakovic, Natalija Filipovic, Lejla Ferhatovic Hamzic, Nenad Kunac, Elena Zdrilic, Marija Vitlov Uljevic, Sandra Kostic, Livia Puljak, Katarina Vukojevic Tags: Original Article Source Type: research
Comorbidities in relation to fatality of first myocardial infarction
Present knowledge concerning potential associations between comorbidities and the fatality of a first myocardial infarction (MI) is limited. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 13, 2017 Category: Cardiology Authors: Hedley Knewjen Quintana, Imre Janszky, Alkass Kanar, Bruna Gigante, Henrik Druid, Anders Ahlbom, Ulf de Faire, Johan Hallqvist, Karin Leander Source Type: research
Cardiac sarcoidosis presenting as arrhythmogenic right ventricular cardiomyopathy/dysplasia with ventricular aneurysms: a case report
A 70-year old Caucasian man with recurrent ventricular tachycardia and progressive biventricular failure attributed to arrhythmogenic right ventricular cardiomyopathy/dysplasia was evaluated for heart transplantation. Cardiac ventriculography revealed an abnormal left ventricle with five saccular aneurysms. Heart transplantation was performed. Pathology of the explanted heart showed multifocal sarcoid granulomas. Replacement fibrosis was widespread in both ventricles and associated with saccular aneurysms. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 10, 2017 Category: Cardiology Authors: Marija Petrovic, L. Maximilian Buja, Biswajit Kar, Jure Colnaric, Sarita Damaraju, Bihong Zhao, Bindu Akkanti, Milan Radovanovic, Rajko Radovancevic, Pranav Loyalka, Igor D. Gregoric Tags: Clinical Case Report Source Type: research
Virtual Journal Club: An Example of the Growing Importance of Social Media in Pathology
Evidence-based medicine is contingent upon an evolving body of data founded on solid, basic research which informs and advances clinical practice. Maintaining an awareness of ever-expanding scientific and clinical knowledge is increasingly a challenge, particularly when factoring in the increasing demands placed on practitioners. Journal clubs evolved in continuing medical education during the 19th century to assist in the task of keeping students of medicine, at all levels, up-to-date [1,2]. From conception, they gained popularity due to their efficacy at propagating new information among medical professionals and by thei...
Source: Cardiovascular Pathology - November 9, 2017 Category: Cardiology Authors: Melanie C. Bois, Joseph J. Maleszewski Tags: Editorial Source Type: research
Betaglycan (TGFBR3) up-regulation correlates with increased TGF- β signaling in Marfan patient fibroblasts in vitro
Marfan syndrome (MFS), a congenital connective tissue disorder leading to aortic aneurysm development, is caused by fibrillin-1 (FBN1) gene mutations. Transforming growth factor beta (TGF- β) might play a role in the pathogenesis. It is still a matter of discussion if and how TGF-β up-regulates the intracellular downstream pathway, although TGF-β receptor 3 (TGFBR3 or Betaglycan) is thought to be involved. We aimed to elucidate the role of TGFBR3 protein in TGF-β signaling in Marf an patients. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 4, 2017 Category: Cardiology Authors: Menno Evert Groeneveld, Natalija Bogunovic, Ren é John Philip Musters, Geert Jan Tangelder, Gerard Pals, Willem Wisselink, Dimitra Micha, Kak Khee Yeung Tags: Original Article Source Type: research
Betaglycan (TGFBR3) upregulation correlates with increased TGF- ß signaling in Marfan patient fibroblasts in vitro
Marfan syndrome (MFS) is a connective tissue disorder that is characterized by abnormalities in the skeletal, ocular, pulmonary, nervous and cardiovascular system.1 –3 The most severe cardiovascular manifestation of MFS is the development of aortic aneurysms (AA), predominantly thoracic AA, which can lead to rupture associated with high mortality.4,5 The syndrome is caused by mutations in the fibrillin-1 gene (FBN1). Fibrillin-1 constitutes the core of microf ibrils, which provide structural stability to extracellular matrix (ECM) and are also responsible for the elastic properties of the vessel wall. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 4, 2017 Category: Cardiology Authors: Menno Evert Groeneveld, Natalija Bogunovic, Ren é John Philip Musters, Geert Jan Tangelder, Gerard Pals, Willem Wisselink, Dimitra Micha, Kak Khee Yeung Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 1, 2017 Category: Cardiology Source Type: research
Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 1, 2017 Category: Cardiology Source Type: research
Clearance of plasmin –PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta
Plasminogen is a circulating zymogen which enters the arterial wall by radial, transmural hydraulic conductance, where it is converted to plasmin by tissue plasminogen activator t-PA on an activation platform involving S100A4 on the vascular smooth muscle cell (vSMC) membrane. Plasmin is involved in the progression of human thoracic aneurysm of the ascending aorta (TAA). vSMCs protect the TAA wall from plasmin-induced proteolytic injury by expressing high levels of antiproteases. Protease nexin-1 (PN-1) is a tissue antiprotease belonging to the serpin superfamily, expressed in the vascular wall, and is able to form a coval...
Source: Cardiovascular Pathology - October 23, 2017 Category: Cardiology Authors: Kamel Boukais, Luciano F. Borges, Laurence Venisse, Ziad Touat, D éborah François, Véronique Arocas, Guillaume Jondeau, Paul Declerck, Marie-Christine Bouton, Jean-Baptiste Michel Tags: Original Article Source Type: research
Clearance of plasmin-PN-1 complexes by vascular smooth muscle cells in human aneurysm of the ascending aorta
Plasminogen, is a circulating zymogen which enters the arterial wall by radial, transmural hydraulic conductance, where it is converted to plasmin by tissue plasminogen activator t-PA, on an activation platform involving S100A4 on the vascular smooth muscle cell (vSMC) membrane. Plasmin is involved in the progression of human thoracic aneurysm of the ascending aorta (TAA). vSMCs protect the TAA wall from plasmin-induced proteolytic injury by expressing high levels of antiproteases. Protease Nexin-1 (PN-1) is a tissue antiprotease belonging to the serpin superfamily, expressed in the vascular wall, and able to form a covale...
Source: Cardiovascular Pathology - October 23, 2017 Category: Cardiology Authors: Kamel Boukais, Luciano F. Borges, Laurence Venisse, Ziad Touat, D éborah François, Véronique Arocas, Guillaume Jondeau, Paul Declerck, Marie-Christine Bouton, Jean-Baptiste Michel Source Type: research
Malignant lymphoma arising in cardiac myxoma, presenting with peripheral arterial emboli
Composite tumors of cardiac myxoma and malignant lymphoma are extremely rare, with 11 of such cases reported in the literature. A 44-year-old man presented to us with abrupt right lower leg pain. A computed tomography angiogram revealed segmental obstruction of the right common femoral artery, and embolectomy was performed. The embolectomy specimen contained several clusters of degenerated round/oval atypical cells in the fibrinous or myxoid background. Immunohistochemical examination revealed that these atypical cells were negative for cytokeratin and non-specifically expressed CD45. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - October 13, 2017 Category: Cardiology Authors: Cheol Keun Park, Yoon Ah Cho, Moon Sik Kim, Hyo Sup Shim Tags: Case report Source Type: research
Globular chitosan treatment of bovine jugular veins: Evidence of anticalcification efficacy in the subcutaneous rat model
Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ( ‘Chitozol’) as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 13, 2017 Category: Cardiology Authors: Anna A. Krasilnikova, David S. Sergeevichev, Vladislav V. Fomenko, Alexander A. Korobeynikov, Maria B. Vasilyeva, Alexander S. Yunoshev, Alexander M. Karaskov, Evgeniy A. Pokushalov Source Type: research
Adventitial tertiary lymphoid organ classification in human atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall. Adjacent to lamina intima lesion progression, a cellular compound develops in the lamina adventitia, defined as tertiary lymphoid organs (TLO) in mice. But in human system, it remains unknown whether these adventitial cellular accumulations represent these highly organized immunological structures. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 7, 2017 Category: Cardiology Authors: Mohammadreza Akhavanpoor, Christian A. Gleissner, Hamidreza Akhavanpoor, Felix Lasitschka, Andreas O. Doesch, Hugo A. Katus, Christian Erbel Tags: Original Article Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 1, 2017 Category: Cardiology Source Type: research
