Retained Surgical Sponge
(See Figs. 1 and 2.) (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 9, 2017 Category: Cardiology Authors: Melanie C. Bois, John P. Bois, Sunil V. Mankad, Phillip M. Young, Joseph John Maleszewski Source Type: research
Progressive heart disease in mucopolysaccharidosis type I mice may be mediated by increased cathepsin B activity
Mucopolysaccharidosis type I (MPS I) is a lysosomal disorder characterized by a deficiency of alpha-L-iduronidase and storage of undegraded glycosaminoglycans (GAGs). Clinical findings of the disease include heart failure, and patients often need valve replacement. It has been shown that later in life, MPS I mice develop those abnormalities, but to date, there have not been studies on the progression and pathogenesis of the disease. Therefore, in the present study, we evaluated heart function in normal and MPS I male mice from 2 to 8 months of age. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 5, 2017 Category: Cardiology Authors: Guilherme Baldo, Angela Maria Vicente Tavares, Esteban Gonzalez, Edina Poletto, Fabiana Quoos Mayer, Ursula da Silveira Matte, Roberto Giugliani Source Type: research
Noncompaction cardiomyopathy in Hirschsprung's disease: a case report
Noncompaction cardiomyopathy is a rare disorder, often associated with cardiac and noncardiac malformations. Hirschsprung's disease, a well-known aganglionosis, is associated with congenital heart diseases and has been reported to be due to impairment migration and differentiation of neural crest cells. Here, we present an 8-month-old male infant who died for cardiogenic shock after surgical resection of the involved bowel segment. The child was affected by both noncompaction cardiomyopathy and Hirschsprung's disease, two entities which can share a common neural crest-derived etiology. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Silvia D. Vison à, Gaetano Thiene, Savina Mannarino, Giulia Corana, Antonio Osculati, Annalisa Angelini, Stefania Rizzo Source Type: research
Association between herpes simplex virus Types 1 and 2 with cardiac myxoma
We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Maryam Sotoudeh Anvari, Moud Sabagh, Hamidreza Goodarzynejad, Shayan Ziaei, Mohammad Ali Boroumand, Leyla Pourgholi, Yaser Jenab, Kyomars Abbasi Source Type: research
Role of miRNA-1 in regulating connexin 43 in ischemia –reperfusion heart injury: a rat model
MiRNA-1 may participate in regulating ischemia –reperfusion injury (IRI) by affecting the expression and distribution of connexin 43 (Cx43). The aim of this study is to investigate miR-1 expression and its potential role in regulating Cx43 during ischemic postconditioning (IPOST) in a rat model. Fifty-five Wistar male rats were randomly divide d into five groups: N, IR, IPOST, agomir-1, and antagomir-1 group. The hearts were perfused with the Langendorff system. The reperfusion arrhythmia (RA) and myocardial infarct size were observed and recorded. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Bo Bian, Xue-Fang Yu, Guo-Qin Wang, Tian-Ming Teng Tags: Original Article Source Type: research
Association between herpes simplex virus types 1 and 2 with cardiac myxomas
We examined if herpes simplex virus (HSV)-1 and HSV-2 antigens and/or DNA could be detected in a cohort of Iranian patients with cardiac myxomas. From July 2004 to June 2014, among a total of 36,703 patients undergoing open heart surgeries, consecutive patients with cardiac myxoma who were treated by surgical excision at our center included in this study. Of 73 patients studied, 56% were female with a mean age of 54 years (ranging from 23 to 77 years). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Maryam Sotoudeh Anvari, Moud Sabagh, Hamidreza Goodarzynejad, Shayan Ziaei, Mohammad Ali Boroumand, Leyla Pourgholi, Yaser Jenab, Kyomars Abbasi Source Type: research
Role of miRNA-1 in regulating connexin 43 in ischemia-reperfusion heart injury: A rat model
MiRNA-1 may participate in regulating ischemia-reperfusion injury (IRI) by affecting the expression and distribution of connexin 43 (Cx43). The aim of this study is to investigate miR-1 expression and its potential role in regulating Cx43 during ischemic postconditioning (IPOST) in a rat model. 55 Wistar male rats were randomly divided into 5 groups: N, IR, IPOST, agomir-1, and antagomir-1 group. The hearts were perfused with the Langendorff system. The reperfusion arrhythmia (RA) and myocardial infarct size were observed and recorded. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Bo Bian, Xue-Fang Yu, Guo-Qin Wang, Tian-Ming Teng Source Type: research
Non-compaction cardiomyopathy in Hirschsprung's disease: a case report
Non-compaction cardiomyopathy is a rare disorder, often associated with cardiac and non-cardiac malformations. Hirschsprung's disease, a well-known aganglionosis, is associated to congenital heart diseases and has been reported to be due to impairment migration and differentiation of neural crest cells. Here, we present a 8-month-old young boy, who died for cardiogenic shock after surgical resection of the involved bowel segment. The child was affected by both non-compaction cardiomyopathy and Hirschsprung's disease, two entities which can share a common neural crest-derived etiology. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Silvia D. Vison à, Gaetano Thiene, Savina Mannarino, Giulia Corana, Antonio Osculati, Annalisa Angelini, Stefania Rizzo Source Type: research
Thrombosis of a mechanical prosthetic aortic valve in early pregnancy: Histopathological findings
We present results of the histopathological workup of a prosthetic aortic valve which was explanted from a 31-year-old woman due to valve thrombosis during early pregnancy. Our images demonstrate nicely thrombotic material directly adherent to the pyrolytic carbon surface in a human specimen. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - January 2, 2017 Category: Cardiology Authors: Roman Scheidmann, Rudi Foth, Matthias Sigler Source Type: research
Deficiency of scavenger receptor class B type 1 leads to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling
Scavenger receptor class B type 1 (SR-BI) is the main high-density lipoprotein (HDL) receptor in mammalians. Loss of SR-BI has been proven to disturb HDL metabolism and accelerate atherosclerosis. However, little is known about the plaque features and arterial remodeling in the increased atherogenesis caused by SR-BI deficiency. Here we explored this issue in atherosclerosis-prone low-density lipoprotein receptor (LDL-R) knockout (KO) mice deficient of SR-BI. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - December 21, 2016 Category: Cardiology Authors: Jiawei Liao, Xin Guo, Mengyu Wang, Mingming Gao, Qiang Shen, Yuhui Wang, Wei Huang, George Liu Tags: Original Article Source Type: research
Role of atrial endothelial cells in the development of atrial fibrosis and fibrillation in response to pressure overload
Monocyte chemoattractant protein-1 (MCP-1)-mediated inflammatory mechanisms have been shown to play a crucial role in atrial fibrosis induced by pressure overload. In the present study, we investigated whether left atrial endothelial cells would quickly respond structurally and functionally to pressure overload to trigger atrial fibrosis and fibrillation.Methods and Results.Six-week-old male Sprague –Dawley rats underwent suprarenal abdominal aortic constriction (AAC) or a sham operation. By day 3 after surgery, macrophages were observed to infiltrate into the endocardium. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - December 13, 2016 Category: Cardiology Authors: Osamu Kume, Yasushi Teshima, Ichitaro Abe, Yuki Ikebe, Takahiro Oniki, Hidekazu Kondo, Shotaro Saito, Akira Fukui, Kunio Yufu, Masahiro Miura, Tatsuo Shimada, Naohiko Takahashi Source Type: research
CaMKII δ Meditates Phenylephrine Induced Cardiomyocyte Hypertrophy Through Store-Operated Ca2+ Entry
This study is aimed to determine the role of CaMKIIδ in regulating the PE induced myocardial hypertrophy and the associated molecular signaling mechanisms. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - December 1, 2016 Category: Cardiology Authors: Yawei Ji, Xin Guo, Zhe Zhang, Zhuyun Huang, Jianghua Zhu, Qing-Hui Chen, Le Gui Source Type: research
Loss of Mechanical Directional Dependency of the Ascending Aorta with Severe Medial Degeneration
Biomechanical characterization of the aortic wall may help risk stratify patients with aneurysms. We investigated the degree of anisotropy, the directional dependency of mechanical properties, in control and aneurysmal ascending aortic tissue. We hypothesized that medial degeneration and aortic wall remodeling as found in aneurysmal tissue, alters energy loss in both the circumferential and longitudinal directions thereby reducing anisotropy. Aneurysmal and control ascending aortic tissue excised during surgery was subjected to biaxial tensile testing. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 14, 2016 Category: Cardiology Authors: Jennifer Chung, Kevin Lachapelle, Raymond Cartier, Rosaire Mongrain, Richard L. Leask Tags: Original Article Source Type: research
A novel role for the Kr üppel-like factor 14 on macrophage inflammatory response and atherosclerosis development
Genome-wide association studies have shown that Kr üppel-like factor 14 (KLF14) is associated with both type 2 diabetes mellitus and lipid metabolism. However, its role in chronic inflammatory responses and the pathogenesis of atherosclerosis remains unknown. The present study was designed to investigate both in vivo and in vitro the impact of KLF1 4 on chronic inflammatory responses and atherosclerosis. ApoE KO mice, a well established animal model of atherosclerosis, had higher expressions of KLF14 in aorta tissues than that in C57BL/6 J mice when fed the high fat diet (HFD) or standard chow diet (SCD). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 13, 2016 Category: Cardiology Authors: Xiao Wei, Ruomei Yang, Chengpan Wang, Xun Jian, Ling Li, Hua Liu, Gangyi Yang, Zhiyong Li Source Type: research
Adverse remodeling of the obtuse marginal artery in compensatory hypertrophied myocardium from spontaneously hypertensive rats
This study was designed to assess remodeling (changes in vascular structure and fibrosis) of this coronary artery. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - November 11, 2016 Category: Cardiology Authors: Bego ña Quintana-Villamandos, María Jesús Delgado-Martos, E Delgado-Baeza Source Type: research
