A novel role for the Kr üppel-like factor 14 on macrophage inflammatory response and atherosclerosis development

Genome-wide association studies have shown that Kr üppel-like factor 14 (KLF14) is associated with both type 2 diabetes mellitus and lipid metabolism. However, its role in chronic inflammatory responses and the pathogenesis of atherosclerosis remains unknown. The present study was designed to investigate both in vivo and in vitro the impact of KLF1 4 on chronic inflammatory responses and atherosclerosis. ApoE KO mice, a well established animal model of atherosclerosis, had higher expressions of KLF14 in aorta tissues than that in C57BL/6 J mice when fed the high fat diet (HFD) or standard chow diet (SCD).
Source: Cardiovascular Pathology - Category: Cardiology Authors: Source Type: research