Sudden unexpected death in early Parkinson's disease: neurogenic or cardiac death?
We present two cases of sudden unexpected death (SUD) in elderly individuals in whom autopsy unexpectedly showed Lewy pathology, a hallmark of Parkinson's disease. Both individuals were 68-year-old males who were found dead in their homes without lethal trauma or poisoning. Inquests into their deaths suggested that non-motor cardiovascular signs of Parkinson's disease might have appeared just before their deaths, although few typical motor signs were present. Autopsy showed Lewy pathology in the heart and peripheral autonomic nervous system in addition to lesser involvement of the brainstem that was consistent with Braak s...
Source: Cardiovascular Pathology - June 15, 2017 Category: Cardiology Authors: Naoki Nishida, Koji Yoshida, Yukiko Hata Tags: Case report Source Type: research
Primary Inferior Vena Cava smooth muscle tumor with diffuse bizarre giant nuclei and low mitotic rate: a nomenclatural conundrum
A male patient with obstructive jaundice was found to have an incidental nodule within the inferior vena cava (IVC), below the level of the renal vein, on abdominal imaging. At the time of the Whipple's procedure for pancreatic adenocarcinoma, the IVC mass measuring 3.4 x 2.7 x 2.2cm, was also removed.Histologically, the lesion was well-circumscribed, composed focally of spindle shaped cells with cigar-shaped nuclei reminiscent of smooth muscle, and a dominant pervasive, pleomorphic, bizarre giant cell component. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 4, 2017 Category: Cardiology Authors: Runjan Chetty, Sangeetha N Kalimuthu, Hanna-Riikka Heinonen Tags: IVC smooth muscle tumor. Source Type: research
Histopathological and biomechanical properties of the aortic wall in 2 patients with chronic type A aortic dissection
Type A aortic dissection is an acute condition that requires urgent surgical intervention. However, in a subset of patients, aortic dissections go undiagnosed and become chronic, thereby allowing the dissected wall to undergo a distinct remodeling process from that of the surrounding intact wall. Here, we observe the biomechanical and histological changes in the aortic wall of two patients with chronic Type A aortic dissection. Partial or complete disruption of the elastic structure of the medial layer was observed in the dissected wall of both patients; however, aortic stiffness in the region of dissection covaried with a...
Source: Cardiovascular Pathology - May 29, 2017 Category: Cardiology Authors: Alexander Emmott, Isma ïl El-Hamamsy, Richard L. Leask Tags: Clinical Case Report Source Type: research
Case Report: Histopathological and biomechanical properties of the aortic wall in 2 patients with chronic type A aortic dissection
Thoracic aortic aneurysms (TAAs) are associated with an increased risk of acute aortic events, especially in patients with familial forms of TAAs. Acute type A aortic dissection represents a life-threatening condition requiring emergency surgical intervention to remove the primary intimal entry tear. In a subset of patients, the dissection goes unnoticed and becomes chronic. Though there is a growing understanding of the pathology and mechanical properties of aneurysmal aortic walls [1, 2], little is known about the characteristics of chronically dissected aortic walls. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 29, 2017 Category: Cardiology Authors: Alexander Emmott, Isma ïl El-Hamamsy, Richard L. Leask Source Type: research
Assessment of Atherosclerotic Luminal Narrowing of Coronary Arteries Based on Morphometrically Generated Visual Guides
Determination of the degree of stenosis of atherosclerotic coronary arteries is an important part of postmortem examination of the heart but, unfortunately, estimation of the degree of luminal narrowing can be imprecise and tend to be approximations. Visual guides can be useful to assess this, but earlier attempts to develop such guides did not employ digital technology. Using this approach we have developed two computer-generated morphometric guides to estimate the degree of luminal narrowing of atherosclerotic coronary arteries. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 29, 2017 Category: Cardiology Authors: Rolf F. Barth, David A. Kellough, Patricia Allenby, Luke E. Blower, Scott H. Hammond, Greg M. Allenby, L. Maximilian Buja Source Type: research
Phospholamban Immunostaining is A Highly Sensitive and Specific Method For Diagnosing Phospholamban p.Arg14del Cardiomyopathy
Phospholamban (PLN) p.Arg14del cardiomyopathy is associated with an increased risk of malignant ventricular arrhythmias and severe heart failure, and a poor prognosis from late adolescence. It can be diagnosed in whole heart specimens, but rarely in right ventricular biopsy specimens, by PLN immunohistochemistry (IHC) showing PLN-containing aggregates concentrated in cardiomyocytes in dense perinuclear aggresomes. The purpose of this study was to determine whether PLN IHC can be used to diagnose PLN p.Arg14del cardiomyopathy using apical left ventricular (LV) myocardial specimens harvested during LV assist device (LVAD) im...
Source: Cardiovascular Pathology - May 29, 2017 Category: Cardiology Authors: Wouter P. te Rijdt, Z. Joy van der Klooster, Edgar T. Hoorntje, Jan D.H. Jongbloed, Paul A. van der Zwaag, Folkert W. Asselbergs, Dennis Dooijes, Rudolf A. de Boer, J. Peter van Tintelen, Maarten P. van den Berg, Aryan Vink, Albert J.H. Suurmeijer Source Type: research
Exercise training ameliorates matrix metalloproteinases 2 and 9 messenger RNA expression and mitigates adverse left ventricular remodeling in streptozotocin-induced diabetic rats
The aim was to investigate whether exercise training (ExT) would ameliorate expression of key genes for myocardial morphostructure and mitigate adverse left ventricular (LV) remodeling in experimental type 1 diabetes (T1D). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 18, 2017 Category: Cardiology Authors: Fl ávio S. Silva, Raul H. Bortolin, Diego N. Araújo, Dáfiny E.S. Marques, João Paulo M.S. Lima, Adriana A. Rezende, Wouber H.B. Vieira, Naisandra B. Silva, Karina C.P. Medeiros, Paul W. Ackermann, Bento J. Abreu, Fernando A.L. Dias Tags: Original Article Source Type: research
Exercise training ameliorates matrix metalloproteinases 2 and 9 mRNA expression and mitigates adverse left ventricular remodeling in streptozotocin-induced diabetic rats
To investigate whether exercise training (ExT) would ameliorate expression of key genes for myocardial morphostructure and mitigate adverse left ventricular (LV) remodeling in experimental type 1 diabetes (T1D). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 18, 2017 Category: Cardiology Authors: Fl ávio S. Silva, Raul H. Bortolin, Diego N. Araújo, Dáfiny E.S. Marques, João Paulo M.S. Lima, Adriana A. Rezende, Wouber H.B. Vieira, Naisandra B. Silva, Karina C.P. Medeiros, Paul W. Ackermann, Bento J. Abreu, Fernando A.L. Dias Tags: Original Article Source Type: research
Adventitial Cystic Disease of Radial Artery. Apropos of A Case and Review of Literature
We report a 72-year-old female patient that underwent surgical treatment of an adventitial cyst of the right radial artery. The involved arterial segment was resected and reconstruction by means of the interposition of a saphenous vein graft was performed. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 11, 2017 Category: Cardiology Authors: Álvaro Torres-Blanco, Luis Ariel Pepén-Moquete, Vicente Molina-Nácher, Francisco Gómez-Palonés Tags: Case Report Source Type: research
Recurrent pulmonary emboli with characteristic histopathology
We present a case of recurrent pulmonary emboli with characteristic histopathology. A 78-year-old patient who developed exertional dyspnea was evaluated at this hospital. Thrombi were detected in the pulmonary artery using contrast-enhanced computed tomography and a diagnosis of pulmonary embolism was made (Fig. 1A). Symptoms were ameliorated by anticoagulation therapy and the size of the thrombus decreased (Fig. 1B). Blood tests did not reveal any coagulation disorders or malignancies. However, one year later, a temporary withdrawal of warfarin due to conjunctival hemorrhage aggravated the dyspnea with an enlargement of t...
Source: Cardiovascular Pathology - May 11, 2017 Category: Cardiology Authors: Sadahiro Hijikata, Takamichi Miyamoto, Junji Yamaguchi, Takamasa Iwai, Keita Watanabe, Yuichiro Sagawa, Ryo Masuda, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Tetsuo Yamaguchi, Nobuhiro Hara, Yasutoshi Nagata, Toshihiro Nozato, Urara Sakurai, Kenz Tags: Case Report Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 1, 2017 Category: Cardiology Source Type: research
Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - May 1, 2017 Category: Cardiology Source Type: research
Clinically Isolated Aortitis: Pitfalls, Progress, and Possibilities
Non-infectious aortitis may be caused by several distinct systemic rheumatologic diseases. In some patients, aortitis is identified either pathologically or radiologically in the absence of clinical evidence of a systemic vasculitis. By consensus nomenclature, such cases are referred to as clinically isolated aortitis (CIA). Some systemic disorders may initially present as CIA including giant cell arteritis (GCA), IgG4-related disease, infectious aortitis, and granulomatosis with polyangiitis. CIA most commonly occurs in women of European descent over the age of 50, and thus mirrors the gender, age, and geographic distribu...
Source: Cardiovascular Pathology - April 23, 2017 Category: Cardiology Authors: Ikay Cinar, He Wang, James R. Stone Source Type: research
Late onset cardiomyopathy as presenting sign of ATTR A45G amyloidosis caused by a novel TTR mutation (p.A65G)
The clinical description of a novel TTR gene mutation characterized by a late onset amyloid cardiomyopathy. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - April 18, 2017 Category: Cardiology Authors: Sebastiaan H.C. Klaassen, Henny H. Lemmink, Johan Bijzet, Andor W.J.M. Glaudemans, Reinhard Bos, Wouter Plattel, Maarten P. van den Berg, Riemer H.J.A. Slart, Hans L.A. Nienhuis, Dirk J. van Veldhuisen, Bouke P.C. Hazenberg Tags: Case Report Source Type: research
Association of Altered Collagen Content and Lysyl Oxidase Expression in Degenerative Mitral Valve Disease
Collagen cross-linking is mediated by lysyl oxidase (LOX) enzyme in the extracellular matrix (ECM) of mitral valve leaflets. Alterations in collagen content and LOX protein expression in the ECM of degenerative mitral valve may enhance leaflet expansion and disease severity. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - April 13, 2017 Category: Cardiology Authors: K-Raman Purushothaman, Meerarani Purushothaman, Irene C. Turnbull, David H. Adams, Anelechi Anyanwu, Prakash Krishnan, Annapoorna Kini, Samin K. Sharma, William N O'Connor, Pedro R. Moreno Source Type: research
