Thrombus on the inflow cannula of the HeartWare HVAD: an update
The HeartWare ™ HVAD™ (Medtronic, Inc., Minneapolis, MN) is a continuous-flow left ventricular assist device (LVAD) approved by the FDA in 2012 as a bridge to transplant in patients with end-stage left ventricular heart failure. The current inflow cannula has a smooth outer surface near the inflow edge and a sintered collar of titanium microspheres near the pump. A previous case series of HVAD patients bridged to transplant revealed thrombus on the outer surface of the inflow cannula in 8/8 patients, predominantly at the smooth-sintered interface, that was associated with a clinical stroke rate of 12.5% . (Source: Card...
Source: Cardiovascular Pathology - September 14, 2018 Category: Cardiology Authors: Carolyn H. Glass, Alexander Christakis, Gregory A. Fishbein, Jaclyn C. Watkins, Kyle C. Strickland, Richard N. Mitchell, Robert F. Padera Tags: Orignal Article Source Type: research
Phenotypic variations in carriers of predicted protein-truncating genetic variants in MYBPC3: an autopsy-based case series
Our aim is to characterize predicted protein-truncating variants (PTVs) in MYBPC3, the gene most commonly associated with hypertrophic cardiomyopathy (HCM), found in a series of autopsied HCM cases after sudden unexpected cardiac death (SUCD). All cases underwent death scene investigation, gross and microscopic autopsies, toxicological testing, a review of medical records, and a molecular analysis of 95 cardiac genes. We found four pathogenic PTVs in MYBPC3 among male decedents. All variants were submitted to ClinVar without phenotype details. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 13, 2018 Category: Cardiology Authors: Nori Williams, Robert Marion, Thomas V. McDonald, Dawei Wang, Bo Zhou, Lucy S. Eng, Sung Yon Um, Ying Lin, Kevin Ruiter, Lisa Rojas, Barbara A. Sampson, Yingying Tang Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 1, 2018 Category: Cardiology Source Type: research
Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - September 1, 2018 Category: Cardiology Source Type: research
Myocardial rupture after small acute myocardial infarction in the absence of coronary artery disease
A 73-year-old woman with a past medical history of hypertension suffered a cardiac arrest. After successful resuscitation, she was hypotensive and tachycardic and the ECG showed ST elevation in the inferior and lateral precordial leads. Coronary angiography did not show evidence of obstructive coronary artery disease. A bedside echocardiogram demonstrated a large pericardial effusion with signs of cardiac tamponade. The echocardiogram and subsequent aortic root angiography did not reveal evidence of dissection. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 25, 2018 Category: Cardiology Authors: C.P. Roth, M. Qarmali, S.H. Litovsky, B.C. Brott Source Type: research
miR-143 and miR-145 promote hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells through regulating ABCA1 expression
Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) plays an important role in the occurrence and development of pulmonary arterial hypertension (PAH). miR-143/145 was reported to be upregulated in the animal models and PAH patients, and deletion of miR-143/145 cluster prevented the development of hypoxia-induced pulmonary hypertension, but its underlying mechanism has not been elucidated. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 23, 2018 Category: Cardiology Authors: Yuxia Yue, Zhiyong Zhang, Lei Zhang, Songhu Chen, Yilin Guo, Yan Hong Tags: Original Article Source Type: research
Potential cardiac consequences of thrombocytopenia and thrombocytosis
This report illustrates the heart in three patients with cardiac hemorrhages associated with extreme thrombocytopenia, and the hearts in three patients with rocks speculated to result at least in part from organization of thrombi possibly related to thrombocytosis in one or more cardiac chambers. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 17, 2018 Category: Cardiology Authors: William C. Roberts, Ishani P. Kale, Joseph M. Guileyardo Tags: Original Article Source Type: research
Tuberculous Myocarditis on autopsy: a rare underdiagnosed entity
Extra pulmonary tuberculosis is very common and has been reported extensively. The disease can affect any organ of the body but there are certain body sites that are rarely affected. It has been proposed that 1 % of all cases of tuberculosis have cardiac involvement [1]. Tuberculous myocarditis is a very rare entity with only a few reported cases in literature [2]. Tuberculosis mostly affects the pericardium but myocardial involvement though known, is very rarely diagnosed during life. The patient may suffer a sudden death and the disease is usually diagnosed at autopsy. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 10, 2018 Category: Cardiology Authors: Sanjay Kumar, Namita Bhutani, Sant Prakash Kataria, Rajeev Sen Tags: Case Report Source Type: research
Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia induced pulmonary hypertension via nuclear factor-kappa B (NFkB)
Chronic hypoxia induced Pulmonary hypertension (PH) is a disorder that is characterized by increased pulmonary arterial pressure resulting from lung diseases or shortage of oxygen in the body. Excess proliferation of pulmonary vascular cells such as pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), plays a critical role in the pathogenesis of PH. Recent evidence indicates that, in addition to genetic predisposition and environmental factors, epigenetic mechanisms play a pivotal role in etiology of PH. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 3, 2018 Category: Cardiology Authors: Yuanshi Li, Sining Liu, Yihong Zhang, Qianping Gao, Weiju Sun, Lu Fu, Junxian Cao Tags: Original Article Source Type: research
Three-dimensional histologic reconstruction of remnant functional accessory atrioventricular myocardial connections in a case of Wolff-Parkinson-white syndrome
Myocardial bundles working as accessory pathways in Wolff-Parkinson-White (WPW) syndrome are generally tiny tissues, so elucidating the culprit histology of atrioventricular (AV) myocardial connections requires careful serial sectioning of the AV junction. We performed a postmortem examination of accessory AV myocardial connections in an 84-year-old man who died from pneumonia 20years after surgical cryoablation for WPW syndrome. Three-dimensional reconstruction images of serial histologic sections revealed accessory AV connections between the atrial and ventricular myocardium in the vicinity of the cryoablation scar. (Sou...
Source: Cardiovascular Pathology - July 26, 2018 Category: Cardiology Authors: Taka-aki Matsuyama, Ryo Haraguchi, Junko Nakashima, Kengo Kusano, Hatsue Ishibashi-Ueda Tags: Case Report Source Type: research
A novel mutation of dystrophin in a Becker muscular dystrophy family with severe cardiac involvement: from genetics to clinicopathology
Dystrophin gene defects are the pathogenic molecular basis of Becker muscular dystrophy (BMD), characterised by skeletal myopathy and cardiomyopathy. Because of the broad phenotype spectrum, it was difficult to use the traditional diagnostic method to achieve an early accurate diagnosis of BMD-associated cardiomyopathy. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 26, 2018 Category: Cardiology Authors: Liang Chen, Jie Ren, Xiao Chen, Kai Chen, Man Rao, Ningning Zhang, Wenhua Yu, Jiangping Song Tags: Case Report Source Type: research
In memoriam Hugh H. McAllister, Jr., M.D.
Our colleague and friend, Hugh Alexander “Chip” McAllister, 79, passed away June 15th in Houston, TX. Dr. McAllister was born in Washington, DC, and was raised in Lumberton, NC. He received his undergraduate education at Davidson College, NC, and his medical education (M.D., 1966) at the University of North Carolina, Chapel Hill. Immed iately after medical school, he began a distinguished Army career as an intern at Walter Reed Army Medical Center. This was followed by training in pathology and cardiac pathology at Walter Reed General Hospital and the Armed Forces Institute of Pathology (AFIP), this last under the guid...
Source: Cardiovascular Pathology - July 22, 2018 Category: Cardiology Authors: L. Maximilian Buja Tags: Editorial Source Type: research
Obituary: in memoriam Hugh H. McAllister, Jr., M.D.
Our colleague and friend, Hugh Alexander “Chip” McAllister, 79, passed away June 15th in Houston, TX. Dr. McAllister was born in Washington, DC, and was raised in Lumberton, NC. He received his undergraduate education at Davidson College, NC, and his medical education (M.D., 1966) at the University of North Carolina, Chapel Hill. Immed iately after medical school, he began a distinguished Army career as an intern at Walter Reed Army Medical Center. This was followed by training in pathology and cardiac pathology at Walter Reed General Hospital and the Armed Forces Institute of Pathology (AFIP), this last under the guid...
Source: Cardiovascular Pathology - July 22, 2018 Category: Cardiology Authors: L. Maximilian Buja Tags: Correspondence Source Type: research
Obituary: in Memoriam Hugh H. McAllister, Jr. MD
Our colleague and friend, Hugh Alexander “Chip” McAllister, 79, passed away June 15th in Houston, Texas. Dr. McAllister was born in Washington, DC and was raised in Lumberton, North Carolina. He received his undergraduate education at Davidson College, North Carolina, and his medical education (MD, 1966) at the University of North Caro lina, Chapel Hill. Immediately after medical school, he began a distinguished Army career as an intern at Walter Reed Army Medical Center. This was followed by training in pathology and cardiac pathology at Walter Reed General Hospital and the Armed Forces Institute of Pathology (AFIP), ...
Source: Cardiovascular Pathology - July 22, 2018 Category: Cardiology Authors: L. Maximilian Buja Tags: Correspondence Source Type: research
Splenectomy had no significant impact on lipid metabolism and atherogenesis in Apoe deficient mice fed on a severe atherogenic diet
For a long time, our major understanding of the spleen is to function as a blood filter for the removal of aged erythrocytes and circulating microorganisms. Splenectomy, therefore, has been widely performed in case of trauma and a variety of hematologic disorders. Although some studies have indicated an increased rate of developing hyperlipidemia and atherosclerotic cardiovascular diseases in splenectomized patients, our recognition of the splenic regulation on lipid metabolism and atherogenesis is still lacking. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 23, 2018 Category: Cardiology Authors: Ying Zhang, Xiang-bo An, Qiu-Yue Lin, Jie Bai, Feng Wang, Jia-wei Liao Tags: Original Article Source Type: research
