Winning the battle, but losing the war: mechanisms and morphology of cancer-therapy-associated cardiovascular toxicity
In the United States, the lifetime risk of a cancer diagnosis is nearly 40%; in 2016, that represents almost 1.6 million new patients, and despite advances in early diagnosis and treatment, roughly 35% will ultimately die of their malignancy. Fortunately, the number of patients living with a cancer diagnosis also continues to expand, anticipated to be more than 19 million in less than a decade. In calculating the relative risks and benefits of therapy, it is therefore important to consider the morbidity and mortality associated with antitumor therapy itself. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Carolyn Kwak Glass, Richard N. Mitchell Tags: Review Article Source Type: research
Cardiac arrest due to ventricular fibrillation in a 23-year-old woman with broken heart syndrome
Broken heart syndrome, also known as takotsubo cardiomyopathy, is a syndrome characterized by a transient regional systolic dysfunction of the left ventricle associated to a psychological stress. We herein describe a case of a 23-year-old female habitual marijuana user who was resuscitated after cardiac arrest and then diagnosed with midventricular stress cardiomyopathy complicated by subendocardial hemorrhage. We discuss this unique pathological finding, the incidence of arrhythmias in this syndrome, and the possible relation with chronic cannabis and tobacco use. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Marco Giuseppe Del Buono, Michael P. O'Quinn, Paulo Garcia, Enrique Gerszten, Charlotte Roberts, F. Gerald Moeller, Antonio Abbate Tags: Clinical Case Report Source Type: research
Tanshinone IIA ameliorated endothelial dysfunction in rats with chronic intermittent hypoxia
The objective of this study was to explore the effect of Tan IIA in endothelium-dependent contracting factors and endothelin receptors in aortic endothelial dysfunction in CIH rats. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Lingling Chen, Qiu-Hong Guo, Yue Chang, Ya-Shuo Zhao, Ai-Ying Li, En-Sheng Ji Source Type: research
Winning the Battle, but Losing the War: Mechanisms and Morphology of Cancer Therapy-Associated Cardiovascular Toxicity
In the United States, the lifetime risk of a cancer diagnosis is nearly 40%; in 2016 that represents almost 1.6 million new patients, and despite advances in early diagnosis and treatment, roughly 35% will ultimately die of their malignancy. Fortunately, the number of patients living with a cancer diagnosis also continues to expand, anticipated to be more than 19 million in less than a decade. In calculating the relative risks and benefits of therapy it is therefore important to consider the morbidity and mortality associated with anti-tumor therapy itself. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Carolyn Kwak Glass, Richard N. Mitchell Source Type: research
Opacification patterns of cardiac masses using low-mechanical index contrast echocardiography: comparison with histopathological findings
Two-dimensional echocardiography is the main non invasive imaging tool to identify cardiac masses but is unable to provide detailed tissue characterization. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Agata Barchitta, Cristina Basso, Pier Giuseppe Piovesana, Francesco Antonini-Canterin, Luisa Ruzza, Alessandra Bianchi, Alberto Banzato, Maurizio Chiesa, Gaetano Thiene, Gino Gerosa, Stefania Rizzo Source Type: research
Cardiac arrest due to ventricular fibrillation in a 23year old woman with broken heart syndrome
We chose to report this case for the following reasons: (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 30, 2017 Category: Cardiology Authors: Marco Giuseppe Del Buono, Michael P. O'Quinn, Paulo Garcia, Enrique Gerszten, Charlotte Roberts, Antonio Abbate Source Type: research
Histological Topography of the Atrioventricular Node and its Extensions in Relation to the Cardiothoracic Surgical Landmarks in Normal Human Hearts
Atrioventricular (AV) nodal injury which results in cardiac conduction disorders is one of the potential complications of heart valve surgeries and radiofrequency catheter ablations. Understanding the topography of the AV conduction system in relation to the tricuspid and mitral valves will help in reducing these complications. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 29, 2017 Category: Cardiology Authors: Arpandeep Randhawa, Tulika Gupta, Anjali Aggarwal, Daisy Sahni, Rana Sandip Singh Tags: Original Article Source Type: research
Editorial Board
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 27, 2017 Category: Cardiology Source Type: research
Table of Contents
(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 27, 2017 Category: Cardiology Source Type: research
Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure
Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, structural remodeling of the atrium plays an important role in the pathogenesis of atrial tachyarrhythmias. Despite the potential value of the atrium in assessment of functional endpoints in myocardial disease, atrial pathologic alterations in mouse models of left ventricular disease have not been systematically investigated. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 21, 2017 Category: Cardiology Authors: Waqas Hanif, Linda Alex, Ya Su, Arti V Shinde, Ilaria Russo, Na Li, Nikolaos G. Frangogiannis Tags: Original Article Source Type: research
Polymer coating embolism from intravascular medical devices — a clinical literature review
Over the past three decades, lubricious (hydrophobic and/or hydrophilic) polymer-coated devices have been increasingly adopted by interventional physicians and vascular surgeons to access and treat a wider range of clinical presentations. Recent clinical literature highlights the presence of polymer coating emboli within the anatomy — a result of coating separation from an intravascular device — and associates it with a range of adverse clinical sequelae. The 2015 U.S. Food and Drug Administration safety communication titled “Lubricious Coating Separation from Intravascular Medical Devices” acknowledges these conce...
Source: Cardiovascular Pathology - June 21, 2017 Category: Cardiology Authors: Amitabh M. Chopra, Monik Mehta, Jean Bismuth, Maksim Shapiro, Michael C. Fishbein, Alina G. Bridges, Harry V. Vinters Tags: Review Article Source Type: research
Left atrial remodeling, hypertrophy and fibrosis in mouse models of heart failure
Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, structural remodeling of the atrium plays an important role in the pathogenesis of atrial tachyarrhythmias. Despite the potential value of the atrium in assessment of functional endpoints in myocardial disease, atrial pathologic alterations in mouse models of left ventricular disease have not been systematically investigated. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 21, 2017 Category: Cardiology Authors: Waqas Hanif, Linda Alex, Ya Su, Arti V Shinde, Ilaria Russo, Na Li, Nikolaos G Frangogiannis Source Type: research
Polymer Coating Embolism from Intravascular Medical Devices – A Clinical Literature Review
Over the past three decades, lubricious (hydrophobic and/or hydrophilic) polymer coated devices have been increasingly adopted by interventional physicians and vascular surgeons to access and treat a wider range of clinical presentations. Recent clinical literature highlights the presence of polymer coating emboli within the anatomy – a result of coating separation from an intravascular device – and associates it with a range of adverse clinical sequelae. The 2015U.S. Food and Drug Administration safety communication titled, ‘Lubricious Coating Separation from Intravascular Medical Devices’, acknowledges these conc...
Source: Cardiovascular Pathology - June 21, 2017 Category: Cardiology Authors: Amitabh M. Chopra, Monik Mehta, Jean Bismuth, Maksim Shapiro, Michael C. Fishbein, Alina G. Bridges, Harry V. Vinters Source Type: research
Intraleaflet hemorrhages are a common finding in symptomatic aortic and mitral valves
We examined the prevalence, age and potential source of ILH in a consecutive series of surgically removed aortic and mitral valves, and related the findings to specific types of heart valve pathology. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - June 16, 2017 Category: Cardiology Authors: Olga C.G. Stam, Mat J.A.P. Daemen, Jan Willem van Rijswijk, Bas A.J.M. de Mol, Allard C. van der Wal Tags: Original Article Source Type: research
Histopathologic Differences Partially Distinguish Syndromic Aortic Diseases
A variety of syndromic diseases such as Marfan syndrome, Loeys-Dietz syndrome, and bicuspid aortic valve with aneurysm along with risk factors of smoking and hypertension result in ascending aortic aneurysms and dissections. Historically, a complicated variety of terms have been used to describe a range of histopathologies that are present in resected specimens. As a result, no consistent patterns of histopathology have been reported. We used the recent SCVP/AECVP consensus statement on nomenclature and diagnostic criteria for noninflammatory aortic disease to blindly evaluate 148 surgically resected specimens. (Source: Ca...
Source: Cardiovascular Pathology - June 15, 2017 Category: Cardiology Authors: Kevin M. Waters, Lisa M. Rooper, Andrew Guajardo, Marc K. Halushka Source Type: research
