Heart Failure Therapies: New Strategies for Old Treatments and New Treatments for Old Strategies
Heart failure, whether acute or chronic, remains a major health care crisis affecting almost 6 million Americans and over 23 million people worldwide. Roughly half of those affected will die within 5 years, and the annual cost exceeds $30 billion in the US alone. Although medical therapy has made some modest inroads in partially stemming the heart failure tsunami, there remains a significant population for whom medication is unsuccessful or has ceased being effective; such patients can benefit from heart transplantation or mechanical circulatory support (MCS). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 28, 2016 Category: Cardiology Authors: Marc K. Halushka, Richard N. Mitchell, Robert F. Padera Source Type: research
Peri-strut micro-hemorrhages: a possible cause of in-stent neoatherosclerosis?
In-stent neoatherosclerosis is characterized by the delayed appearance of markers of atheroma in the sub-intima, but the pathophysiology underlying this new disease entity remains unclear. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 28, 2016 Category: Cardiology Authors: Zaven Terzian, T. Christian Gasser, Francis Blackwell, Fabien Hyafil, Liliane Louedec, Catherine Deschildre, Walid Ghodbane, Richard Dorent, Antonino Nicoletti, Marion Morvan, Mohammed Nejjari, Laurent Feldman, Graciela Pavon-Djavid, Jean-Baptiste Michel Source Type: research
Anatomopathological changes of the cardiac conduction system in sudden cardiac death, particularly in infants: advances over the last 25 years
Sudden cardiac death (SCD) is defined as the unexpected death without an obvious noncardiac cause that occurs within 1 h of witnessed symptom onset (established SCD) or within 24 h of unwitnessed symptom onset (probable SCD). In the United States, its incidence is 69/100,000 per year. Dysfunctions of the cardiac conduction and autonomic nervous systems are known to contribute to SCD pathogenesis, even if most clinicians and cardiovascular pathologists lack experience with detailed examination of the cardiac conduction system and fail to recognize lesions that are crucial to explain the SCD itself. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 27, 2016 Category: Cardiology Authors: Giulia Ottaviani, L. Maximilian Buja Tags: Original Article Source Type: research
Anatomo-Pathological Changes of the Cardiac Conduction System in Sudden Cardiac Death, Particularly in Infants: Advances over the Last 25 Years
Sudden cardiac death (SCD) is defined as the unexpected death without an obvious noncardiac cause that occurs within one hour of witnessed symptom onset (established SCD) or within 24 h of unwitnessed symptom onset (probable SCD). In the USA, its incidence is 69/100,000 per year. Dysfunctions of the cardiac conduction and autonomic nervous systems are known to contribute to SCD pathogenesis, even if most clinicians and cardiovascular pathologists lack experience with detailed examination of the cardiac conduction system and fail to recognize lesions that are crucial to explain the SCD itself. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 27, 2016 Category: Cardiology Authors: Giulia Ottaviani, L. Maximilian Buja Source Type: research
Lipomatous Hamartoma-like Lesion of a Bicuspid Aortic Valve: An incidental surgical finding
We report a quite unique case of a lipomatous hamartoma-like lesion involving a bicuspid aortic valve. The lesion was incidentally found in a young patient undergoing cardiac surgery for aortic regurgitation and the diagnosis was done by histology. It cannot be excluded that the lipomatous hamartoma-like lesion might have contributed to aortic valve regurgitation. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 27, 2016 Category: Cardiology Authors: Andrea De Martino, Stefania Blasi, Daniele Lorenzini, Mariagrazia Fornaro, Fulvio Basolo, Uberto Bortolotti, Angela Pucci Tags: Case Report Source Type: research
Paraffin processing of stented arteries using a postfixation dissolution of metallic and polymeric stents
Studying the morphology of the arterial response to endovascular stent implantation requires embedding the explanted stented artery in rigid materials such as poly(methyl methacrylate) to enable sectioning through both the in situ stent and the arterial wall, thus maintaining the proper anatomic relationships. This is a laborious, time-consuming process. Moreover, the technical quality of stained plastic sections is typically suboptimal and, in some cases, precludes immunohistochemical analysis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 20, 2016 Category: Cardiology Authors: Ilia Fishbein, Tre Welch, David T. Guerrero, Ivan S. Alferiev, Richard F. Adamo, Michael Chorny, Rohit K. Gupte, Yanqing Tang, Robert J. Levy Tags: Original Article Source Type: research
Carbonic Anhydrase Inhibitors Reduce Cardiac Dysfunction after Sustained Coronary Artery Ligation in Rats
Two potent carbonic anhydrase (CA) inhibitors with widely differing membrane permeability, poorly diffusible benzolamide (BZ) and highly diffusible ethoxzolamide (ETZ) were assessed to determine whether they can reduce cardiac dysfunction in rats subjected to coronary artery ligation (CAL)-induced myocardial infarction. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 20, 2016 Category: Cardiology Authors: Lorena A. Vargas, Oscar A. Pinilla, Romina G. D íaz, Diana E. Sepúlveda, Erik R. Swenson, Néstor G. Pérez, Bernardo V. Álvarez Source Type: research
Endoglin Selectively Modulates Transient Receptor Potential Channel Expression in Left and Right Heart Failure
Transient receptor potential (TRP) channels are broadly expressed cation channels that mediate diverse physiological stimuli and include canonical (TRPC), melastatin (TRPM) and vanilloid (TRPV) subtypes. Recent studies have implicated a role for TRPC6 channels as an important component of signaling via the cytokine, transforming growth factor beta 1 (TGFb1) in right (RV) or left ventricular (LV) failure. Endoglin is a transmembrane glycoprotein that promotes TRPC6 expression and TGFb1 activity. No studies have defined biventricular expression of all TRP channel family members in heart failure. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 20, 2016 Category: Cardiology Authors: Kevin J. Morine, Vikram Paruchuri, Xiaoying Qiao, Mark Aronovitz, Gordon S. Huggins, David DeNofrio, Michael S. Kiernan, Richard H. Karas, Navin K. Kapur Source Type: research
Paraffin Processing of Stented Arteries Using a Post-Fixation Dissolution of Metallic and Polymeric Stents
Studying the morphology of the arterial response to endovascular stent implantation, requires embedding the explanted stented artery in rigid materials such as poly (methyl methacrylate) to enable sectioning through both the in situ stent and the arterial wall, thus maintaining the proper anatomic relationships. This is a laborious, time consuming process. Moreover, the technical quality of stained plastic sections is typically suboptimal, and in some cases precludes immunohistochemical analysis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 20, 2016 Category: Cardiology Authors: Ilia Fishbein, Tre Welch, David T. Guerrero, Ivan S. Alferiev, Richard F. Adamo, Michael Chorny, Rohit K. Gupte, Yanqing Tang, Robert J. Levy Source Type: research
The Impact of Splenectomy on Human Coronary Artery Atherosclerosis and Vascular Macrophage Distribution
In this study, the direct impact of splenectomy on human coronary artery atherosclerotic plaque severity and macrophage content was investigated. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - August 2, 2016 Category: Cardiology Authors: Yu Li, James R. Stone Source Type: research
A novel LAMP2 mutation associated with severe cardiac hypertrophy and microvascular remodeling in a female with Danon disease: a case report and literature review
Danon disease (DD) is a rare disorder characterized by cardiomyopathy, intellectual disability, and proximal myopathy. It is caused by mutations in the LAMP2 gene on X chromosome. Female patients most often present with late-onset cardiomyopathy and slow disease progression, but early-onset cases with unfavorable prognosis have been reported. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 24, 2016 Category: Cardiology Authors: Irene Bottillo, Carla Giordano, Bruna Cerbelli, Daniela D'Angelantonio, Martina Lipari, Taisia Polidori, Silvia Majore, Enrico Bertini, Adele D'Amico, Diana Giannarelli, Carmelilia De Bernardo, Laura Masuelli, Francesco Musumeci, Andrea Avella, Federica R Tags: Case Report Source Type: research
Cardiovascular medicine in Morgagni's De sedibus: Dawn of cardiovascular pathology
The most significant cardiovascular anatomo-clinical observations from Morgagni's masterpiece De sedibus et causis morborum per anatomen indagatis (1761) are herein reported, divided into the current taxonomy according to cardiac structure: A) aorta and pulmonary artery; B) pericardium, C) coronary arteries, D) myocardium, E) endocardium, F) congenital heart defects, and G) heart rhythm disorders. Morgagni's interpretations in cardiovascular pathology were strictly related with the most advanced theories of his time, such as those of blood circulation and iatromechanics, nevertheless he remained close to the empirical desc...
Source: Cardiovascular Pathology - July 24, 2016 Category: Cardiology Authors: Fabio Zampieri, Alberto Zanatta, Cristina Basso, Gaetano Thiene Source Type: research
A novel LAMP2 mutation associated with severe cardiac hypertrophy and microvascular remodelling in a female with Danon disease: a case report and literature review
Danon disease (DD) is a rare disorder characterized by cardiomyopathy, intellectual disability and proximal myopathy. It is caused by mutations in the LAMP2 gene on X chromosome. Female patients most often present with late onset cardiomyopathy and slow disease progression, but early-onset cases with unfavourable prognosis have been reported. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 24, 2016 Category: Cardiology Authors: Bottillo Irene, Giordano Carla, Cerbelli Bruna, D'Angelantonio Daniela, Lipari Martina, Polidori Taisia, Majore Silvia, Bertini Enrico, D'Amico Adele, Giannarelli Diana, De Bernardo Carmelilia, Masuelli Laura, Musumeci Francesco, Avella Andrea, Re Federic Source Type: research
Cardiovascular medicine in Morgagni's De sedibus: Dawn of cardiovascular pathology
The most significant cardiovascular anatomo-clinical observations from Morgagni's masterpiece De sedibus et causis morborum per anatomen indagatis (1761) are herein reported, divided into the current taxonomy according to cardiac structure: A) aorta and pulmonary artery; B) pericardium, C) coronary arteries, D) myocardium, E) endocardium, F) congenital heart defects, and G) heart rhythm disorders. Morgagni's interpretations in cardiovascular pathology were strictly related with the most advanced theories of his time, such as those of blood circulation and iatromechanics, nevertheless he remained close to the empirical desc...
Source: Cardiovascular Pathology - July 24, 2016 Category: Cardiology Authors: Fabio Zampieri, Alberto Zanatta, Cristina Basso, Gaetano Thiene Source Type: research
A novel LAMP2 mutation associated with severe cardiac hypertrophy and microvascular remodelling in a female with Danon disease: a case report and literature review
Danon disease (DD) is a rare disorder characterized by cardiomyopathy, intellectual disability and proximal myopathy. It is caused by mutations in the LAMP2 gene on X chromosome. Female patients most often present with late onset cardiomyopathy and slow disease progression, but early-onset cases with unfavourable prognosis have been reported. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - July 24, 2016 Category: Cardiology Authors: Bottillo Irene, Giordano Carla, Cerbelli Bruna, D'Angelantonio Daniela, Lipari Martina, Polidori Taisia, Majore Silvia, Bertini Enrico, D'Amico Adele, Giannarelli Diana, De Bernardo Carmelilia, Masuelli Laura, Musumeci Francesco, Avella Andrea, Re Federic Source Type: research
