Endoglin Selectively Modulates Transient Receptor Potential Channel Expression in Left and Right Heart Failure

Transient receptor potential (TRP) channels are broadly expressed cation channels that mediate diverse physiological stimuli and include canonical (TRPC), melastatin (TRPM) and vanilloid (TRPV) subtypes. Recent studies have implicated a role for TRPC6 channels as an important component of signaling via the cytokine, transforming growth factor beta 1 (TGFb1) in right (RV) or left ventricular (LV) failure. Endoglin is a transmembrane glycoprotein that promotes TRPC6 expression and TGFb1 activity. No studies have defined biventricular expression of all TRP channel family members in heart failure.

Source: Cardiovascular Pathology - August 20, 2016 Category: Cardiology Authors: Kevin J. Morine, Vikram Paruchuri, Xiaoying Qiao, Mark Aronovitz, Gordon S. Huggins, David DeNofrio, Michael S. Kiernan, Richard H. Karas, Navin K. Kapur Source Type: research