C reactive protein and enzymatically modified LDL cooperatively promote dendritic cell-mediated T cell activation
This study aimed to investigate whether eLDL and CRP could cooperatively promote dendritic cells (DCs) mediated T cell activation and proliferation. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - April 7, 2017 Category: Cardiology Authors: Wei He, Yong Ren, Xiao Wang, Qiao Chen, Shifang Ding Source Type: research
Left ventricular outflow tract rupture during transcatheter aortic valve implantation: Anatomic evidence of the vulnerable area
Transcatheter aortic valve implantation (TAVI) has become the standard of care in inoperable or high-risk patients with aortic valve stenosis [1], and an ever-growing number of intermediate-risk patients are now being treated with TAVI worldwide [2]. The expansion of the use of TAVI to a younger, lower risk population mandates a reduction in procedural complications (i.e. stroke, acute coronary occlusion, aortic rupture, conduction disturbances with pacemaker implantations, paravalvular leak and vascular complications). (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - April 4, 2017 Category: Cardiology Authors: Giuseppe Tarantini, Cristina Basso, Luca Nai Fovino, Chiara Fraccaro, Gaetano Thiene, Stefania Rizzo Tags: Original Article Source Type: research
Syndecan-4 deficiency accelerates the transition from compensated hypertrophy to heart failure following pressure overload
Increasing evidence suggests that a mismatch between angiogenesis and myocardial growth contributes to the transition from adaptive cardiac hypertrophy to heart failure following pressure overload. Syndecan-4 is a transmembrane proteoglycan that binds to growth factors and extracellular matrix proteins and is critical in focal adhesion formation. However, its effects on coronary angiogenesis during pressure overload-induced heart failure have not been studied. Here, we hypothesize that syndecan-4 modulates cardiac remodeling in response to pressure overload through its ability to regulate adaptive angiogenesis. (Source: Ca...
Source: Cardiovascular Pathology - March 29, 2017 Category: Cardiology Authors: Guannan Li, Jun Xie, Jianzhou Chen, Ran Li, Han Wu, Xinlin Zhang, Qinhua Chen, Rong Gu, Biao Xu Source Type: research
Corynebacterium propinquum Endocarditis: a Confounding Presentation of a Rare Entity
We report a unique case of Corynebacterium propinquum endocarditis in an otherwise healthy individual, and it is the first example of this organism causing culture-negative endocarditis. Conflicting clinical and microbiological data led to the use of sequencing to confirm the causative organism. This case illustrates Corynebacterium propinquum as a cause of infective endocarditis, and it demonstrates the utility of ancillary molecular diagnostic techniques to identify etiologic agents in difficult cases of infective endocarditis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 22, 2017 Category: Cardiology Authors: Bryan Rea, Jaleah Hawkins, Htun Min, Richard Maniglia, Naasha Talati, Laurel Glaser Tags: Case Report Source Type: research
Calcifying giant cell cardiomyopathy: a possible new entity
We demonstrated an extremely unusual case of an 83-year-old male's sudden death secondary to characteristic myocardial necrosis and fibrosis with calcification and multinucleated giant cells infiltration, possibly due to sepsis and Stage IV pulmonary pleomorphic carcinoma-induced cachexia after postmortem study. We propose that this calcifying giant cell cardiomyopathy (CGC) would be a new entity especially from the pathological viewpoints and should be considered in the classification of noninfectious myocarditis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 11, 2017 Category: Cardiology Authors: Ke-Yong Wang, Sohsuke Yamada, Shohei Shimajiri, Ryuji Nakano, Naoki Yamashita, Tetsuya So, Akihide Tanimoto Tags: Case Report Source Type: research
Intramyocardial bronchogenic cyst: histological appearance and a review of the literature
We report histological appearance of a bronchogenic cyst that was incidentally found in 78-year-old man who died from drowning related to a traumatic accident. The cyst was found in the posterior edge of the interventricular septum and was monolocular with a 5-mm diameter. The cystic wall was not associated with cartilage or the smooth muscle layer, and was lined by ciliated respiratory epithelium. Immunohistochemistry showed that many of these epithelial cells were positive for cytokeratin 7 and thyroid transcription factor-1. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 11, 2017 Category: Cardiology Authors: Naoki Nishida, Yukiko Hata, Kazuhiro Nomoto Tags: Case report Source Type: research
R1: Calcifying Giant Cell Cardiomyopathy: A Possible New Entity
We demonstrated an extremely unusual case of an 83-year-old male's sudden death secondary to characteristic myocardial necrosis and fibrosis with calcification and multinucleated giant cells infiltration, possibly due to sepsis and stage IV pulmonary pleomorphic carcinoma-induced cachexia after postmortem study. We propose that this calcifying giant cell cardiomyopathy (CGC) would be a new entity especially from the pathological viewpoints and should be considered in the classification of noninfectious myocarditis. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 11, 2017 Category: Cardiology Authors: Ke-Yong Wang, Sohsuke Yamada, Shohei Shimajiri, Ryuji Nakano, Naoki Yamashita, Tetsuya So, Akihide Tanimoto Source Type: research
Lymphocyte-rich capillary –cavernous hemangioma of the mitral valve: a case report and review of the literature
In this report, we describe a 62-year-old man who presented with mild edema of the lower limbs. An echocardiogram revealed an incidental 1.3-cm diameter mass on the anterior mitral valve leaflet for which he underwent surgical resection and mitral valve replacement. Histopathological examination showed a lymphocyte-rich capillary –cavernous hemangioma. The exuberant lymphoid stroma is unusual for hemangioma and represents an undescribed pattern of cardiac hemangioma. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 9, 2017 Category: Cardiology Authors: J. Fernando Val-Bernal, Nuria Ter án-Villagrá, Olga GarcÃa-Diego, José A. Sarralde Tags: Original Article Source Type: research
Lymphocyte-rich capillary-cavernous hemangioma of the mitral valve: a case report and review of the literature
In this report, we describe a 62-year-old man who presented with mild edema of the lower limbs. An echocardiogram revealed an incidental 1.3-cm diameter mass on the anterior mitral valve leaflet for which he underwent surgical resection and mitral valve replacement. Histopathological examination showed a lymphocyte-rich capillary-cavernous hemangioma. The exuberant lymphoid stroma is unusual for hemangioma and represents an undescribed pattern of cardiac hemangioma. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 9, 2017 Category: Cardiology Authors: J. Fernando Val-Bernal, Nuria Ter án-Villagrá, Olga GarcÃa-Diego, José A. Sarralde Tags: Original Article Source Type: research
Primary intracardiac leiomyoma arising from cardiomyocyte progenitors at the right ventriculoseptal interface: case report with literature review
Primary cardiac neoplasms are rare and are usually benign myxomas and rhabdomyomas. Cardiac leiomyomas are usually seen as a part of the spectrum of intravenous leiomyomatosis or benign metastasizing leiomyoma. De novo occurrence of primary intracardiac leiomyomas (PICL) is a rarity. Herein we describe a 14-year-old boy presenting with intermittent dyspnea for 2 years, with a large right ventricular mass suggestive of myxoma on transthoracic echocardiography, without any extracardiac lesions. Histology and immunohistochemistry of the tumor excised under cardiopulmonary bypass confirmed a PICL arising at the cardiomyocyte â...
Source: Cardiovascular Pathology - March 7, 2017 Category: Cardiology Authors: Kavita Gaur, Kaushik Majumdar, Navnita Kisku, Ranjana Gondal, Puja Sakhuja, Deepak Kumar Satsangi Tags: Original Article Source Type: research
Primary intracardiac leiomyoma arising from cardiomyocyte progenitors at the right ventriculo-septal interface: Case report with literature review
Primary cardiac neoplasms are rare, and are usually benign myxomas and rhabdomyomas. Cardiac leiomyomas are usually seen as a part of the spectrum of intravenous leiomyomatosis or benign metastasizing leiomyoma. De novo occurrence of primary intracardiac leiomyomas (PICL) is a rarity. Herein we describe a 14year old boy presenting with intermittent dyspnea for two years, with a large right ventricular mass suggestive of myxoma on transthoracic echocardiography, without any extracardiac lesions. Histology and immunohistochemistry of the tumour excised under cardiopulmonary bypass confirmed a PICL arising at the cardiomyocyt...
Source: Cardiovascular Pathology - March 7, 2017 Category: Cardiology Authors: Kavita Gaur, Kaushik Majumdar, Navnita Kisku, Ranjana Gondal, Puja Sakhuja, Deepak Kumar Satsangi Tags: Original Article Source Type: research
Coronary Fat Embolism following Subarachnoid Hemorrhage: An Experimental Study
This study aimed to investigate the possible effect of NPE on the development of coronary fat embolism. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 6, 2017 Category: Cardiology Authors: Ednan Bayram, Canan Atalay, Ender Alta ş, Yavuzer Koza, Eşref Kabalar, Mahmut Açıkel, Mehmet Dumlu Aydın Tags: Original Article Source Type: research
Aortic Calcified Particles Modulate Valvular Endothelial and Interstitial Cells
Normal and calcified human valve cusps, coronary arteries and aortae harbour spherical calcium phosphate micro-particles of the identical composition and crystallinity and their role remains unknown. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 2, 2017 Category: Cardiology Authors: Nicole C.A. van Engeland, Sergio Bertazzo, Padmini Sarathchandra, Ann McCormack, Carlijn V.C. Bouten, Magdi H Yacoub, Adrian H Chester, Najma Latif Tags: Original Article Source Type: research
Zygomycotic Infective Endocarditis in Pregnancy
We report a fatal case of zygomycotic valvular and mural endocarditis in a young non-diabetic primigravida with a positive hepatitis B serology. (Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 2, 2017 Category: Cardiology Authors: Pradeep Vaideeswar, Rushabh Shah Source Type: research
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(Source: Cardiovascular Pathology)
Source: Cardiovascular Pathology - March 1, 2017 Category: Cardiology Source Type: research
