Left atrial remodeling, hypertrophy and fibrosis in mouse models of heart failure

Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, structural remodeling of the atrium plays an important role in the pathogenesis of atrial tachyarrhythmias. Despite the potential value of the atrium in assessment of functional endpoints in myocardial disease, atrial pathologic alterations in mouse models of left ventricular disease have not been systematically investigated.

Source: Cardiovascular Pathology - June 21, 2017 Category: Cardiology Authors: Waqas Hanif, Linda Alex, Ya Su, Arti V Shinde, Ilaria Russo, Na Li, Nikolaos G Frangogiannis Source Type: research