Changes in neurofilament 200 and tyrosine hydroxylase expression in the cardiac innervation of diabetic rats during ageing

Changes in sensory and sympathetic innervation during diabetes mellitus (DM) can be a predictor of arrhythmias, silent myocardial ischemia and chronic heart failure, but knowledge about these changes is still unsatisfactorily. We analysed whether prolonged DM induces changes in density of sensory and sympathetic nerve terminals of rat's heart, and whether it contributes to cardiomyopathy during ageing. DM was induced by i/p injecting 55 mg/kg streptozotocin (STZ) to male Sprague-Dawley rats, while a control group received a citrate buffer.

Source: Cardiovascular Pathology - November 15, 2017 Category: Cardiology Authors: Marija Bakovic, Natalija Filipovic, Lejla Ferhatovic Hamzic, Nenad Kunac, Elena Zdrilic, Marija Vitlov Uljevic, Sandra Kostic, Livia Puljak, Katarina Vukojevic Tags: Original Article Source Type: research