Pathological evidence of adrenergic cardiac denervation in a patient with congestive heart failure

Autonomic dysfunction, with sympathetic hyperactivity and parasympathetic depression, is a key component of congestive heart failure (CHF) and a therapeutic target. Impaired autonomic modulation correlates inversely with survival, and an inverse correlation between chronotropic incompetence and exercise capacity has also been reported [1]. Finally, in patients with CHF, cardiac denervation is associated with sudden death [2]. All these findings justify further study of cardiac innervation.

Source: Cardiovascular Pathology - June 5, 2018 Category: Cardiology Authors: D Acanfora, G Casucci, MM Ciccone, P Scicchitano, T Lonobile, L Chiariello, R Maestri, C Pedone, V Provitera, M Nolano, R Antonelli Incalzi Tags: Case Report Source Type: research