CD39 and CD73 in the aortic valve —biochemical and immunohistochemical analysis in valve cell populations and its changes in valve mineralization

The calcific aortic valve disease (CAVD) is a common heart pathology that involves inflammation, fibrosis, and calcification of aortic valve leaflets. All these processes could be affected by changes in the extracellular purinergic signaling that depend on the activity of ectonucleotidases, mainly ectonucleoside triphosphate diphosphohydrolase 1 (CD39, eNTPD1) and ecto-5 ’nucleotidase (CD73, e5NT).

Source: Cardiovascular Pathology - June 7, 2018 Category: Cardiology Authors: Ewa Kaniewska-Bednarczuk, Barbara Kutryb-Zajac, Padmini Sarathchandra, Iwona Pelikant-Malecka, Alicja Sielicka, Izabela Piotrowska, Ewa M. Slominska, Adrian H. Chester, Magdi H. Yacoub, Ryszard T. Smolenski Tags: Original Article Source Type: research