Increased β-Catenin Accumulation and Nuclear Translocation are Associated with Concentric Hypertrophy in Cardiomyocytes
Defective Wnt/ β-Catenin signaling, activated under various pathological conditions can result in cardiac and vascular abnormalities. In the present study, the possible role of β-catenin over expression during cardiac hypertrophy was investigated. 10 samples from hearts of human patients with acute infarction, g ranulation tissue from 20 patients and 10 from normal ones were collected in order to investigate roles of β-catenin in cardiac hypertrophy. H9c2 cardiomyoblast cells and Wistar rat primary neonatal cardiomyocytes were overexpressed with β-catenin.
Source: Cardiovascular Pathology - Category: Cardiology Authors: Cheng-Yu Lee, Wei Wen Kuo, Rathinasamy Baskaran, Cecilia Hsuan Day, Pei Ying Pai, Chao Hung Lai, Yu-Feng Chen, Ray-Jade Chen, Viswanadha Vijaya Padma, Chih Yang Huang Source Type: research
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