Increased β-Catenin Accumulation and Nuclear Translocation are Associated with Concentric Hypertrophy in Cardiomyocytes

Defective Wnt/ β-Catenin signaling, activated under various pathological conditions can result in cardiac and vascular abnormalities. In the present study, the possible role of β-catenin over expression during cardiac hypertrophy was investigated. 10 samples from hearts of human patients with acute infarction, g ranulation tissue from 20 patients and 10 from normal ones were collected in order to investigate roles of β-catenin in cardiac hypertrophy. H9c2 cardiomyoblast cells and Wistar rat primary neonatal cardiomyocytes were overexpressed with β-catenin.
Source: Cardiovascular Pathology - Category: Cardiology Authors: Source Type: research