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Elevated body mass index and decreased diet quality among women and risk of birth defects in their offspring
ConclusionThese findings provide evidence for the hypothesis of highest birth defect risks among offspring to women who are obese and have low diet quality but insufficient evidence for an interaction of these factors in their contribution to risk. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - December 1, 2015 Category: Perinatology & Neonatology Authors: Suzan L Carmichael, Wei Yang, Suzanne Gilboa, Elizabeth Ailes, Adolfo Correa, Lorenzo D Botto, Marcia L Feldkamp, Gary M Shaw, Tags: Original Research Article Source Type: research

Population‐based birth defects data in the United States, 2008 to 2012: Presentation of state‐specific data and descriptive brief on variability of prevalence
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 19, 2015 Category: Perinatology & Neonatology Authors: Cara T. Mai, Jennifer Isenburg, Peter H. Langlois, CJ Alverson, Suzanne M. Gilboa, Russel Rickard, Mark A. Canfield, Suzanne B. Anjohrin, Philip J. Lupo, Deanna R. Jackson, Erin B. Stallings, Angela E. Scheuerle, Russell S. Kirby, Tags: Brief Report Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 19, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Long‐term survival for infants born with orofacial clefts in Western Australia
CONCLUSIONParents with a child diagnosed with an OFC ± additional minor anomalies only can be reassured that the OFC does not influence survival rates in infancy, or long‐term. Infant survival was lower only for children with OFC and additional major anomalies. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 1, 2015 Category: Perinatology & Neonatology Authors: Jane C. Bell, Natasha Nassar, Carol Bower, Robin M. Turner, Camille Raynes‐Greenow Tags: Original Research Article Source Type: research

Variability in a three‐generation family with pierre robin sequence, acampomelic campomelic dysplasia, and intellectual disability due to a novel ∼1 Mb deletion upstream of SOX9, and including KCNJ2 and KCNJ16
ConclusionThe identified deletion was smaller than all other chromosome rearrangements associated with ACD. Comparison with other reported translocations and deletions involving this region allowed further refining of genotype–phenotype correlations and an update of the smallest regions of overlap associated with the different phenotypes. Intrafamilial variability in this pedigree suggests a phenotypic continuity between ACD and PRS in patients carrying mutations in the SOX9 5′ regulatory region. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and ...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 1, 2015 Category: Perinatology & Neonatology Authors: Marco Castori, Irene Bottillo, Silvia Morlino, Chiara Barone, Piero Cascone, , Paola Grammatico, Luigi Laino Tags: Brief Report Source Type: research

Replication analysis of 15 susceptibility loci for nonsyndromic cleft lip with or without cleft palate in an italian population
CONCLUSIONDifferent loci, including 8q24 and 1p22 have been found associated with nsCL/P in multiple populations. Further efforts are needed to identify causative variants and transfer knowledge to clinical application, such as personal genetic risk assessment. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 1, 2015 Category: Perinatology & Neonatology Authors: Francesca Cura, Anne C. Böhmer, Johanna Klamt, Hannah Schünke, Luca Scapoli, Marcella Martinelli, Francesco Carinci, Markus M. Nöthen, Michael Knapp, Kerstin U. Ludwig, Elisabeth Mangold Tags: Original Research Article Source Type: research

Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish
ConclusionThese studies demonstrate that while reduction of either RA or Shh signaling produces the same disruption of MHB or ocular development, that can be phenocopied using ethanol combined with either MO, RA overexpression can only rescue disrupted MHB, but not microphthalmia, in combined subthreshold Shh MO and ethanol. Our data suggest that MHB development may involve crosstalk between RA and Shh signaling, while ocular development depends on RA and Shh signaling that both are targets of ethanol in fetal alcohol spectrum disorders but do not depend on a mechanism involving crosstalk. Birth Defects Research (Part A), ...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 16, 2015 Category: Perinatology & Neonatology Authors: Chengjin Zhang, Ashley Anderson, Gregory J. Cole Tags: Original Research Article Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 15, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Population‐based birth defects surveillance data: The cornerstone of epidemiologic and health services research and disease prevention
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 1, 2015 Category: Perinatology & Neonatology Authors: Russell S. Kirby, Marilyn L. Browne Tags: Editorial Source Type: research

Success rates for consent and collection of prenatal biological specimens in an epidemiologic survey of child health
ConclusionHigh rates of consent for and collection of a wide variety of biospecimens can be achieved in prospective epidemiologic cohort studies of pregnant women. Ease of sample collection may be a primary factor influencing successful biospecimen collection. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 26, 2015 Category: Perinatology & Neonatology Authors: Omar A. Abdul‐Rahman, Beatriz Rodriguez, Sandra R. Wadlinger, Julia Slutsman, Elizabeth B. Boyle, Lori S. Merrill, Jeffrey Botkin, Jack Moye Tags: Research Article Source Type: research

Reduction in cadmium‐induced toxicity by c‐Jun modulation in mouse embryo limb bud cells
ConclusionThe JNK pathway, and particularly the downstream effector c‐Jun, appears to play an important role in regulating cell survival and differentiation in mouse embryo limb bud cells both in the presence and absence of the toxic metal cadmium. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 26, 2015 Category: Perinatology & Neonatology Authors: Carolyn M. Kapron, Le Cheng Tags: Original Research Source Type: research

Time trends in prevalence of gastroschisis in Texas, 1999 to 2011: Subgroup analyses by maternal and infant characteristics
ConclusionThis study confirms the increasing prevalence of gastroschisis over the time period 1999 to 2011 in Texas. The results suggest that no population subgroups are experiencing a significantly different increase in gastroschisis prevalence over time than others. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 26, 2015 Category: Perinatology & Neonatology Authors: Loc‐Uyen T. Vo, Peter H. Langlois Tags: Original Research Article Source Type: research

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice
ConclusionDeficiency of the MTHFD1 10‐formyltetrahydrofolate synthetase activity in embryos is associated with increased incidence of congenital heart defects. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 26, 2015 Category: Perinatology & Neonatology Authors: Karen E. Christensen, Liyuan Deng, Renata H. Bahous, Loydie A. Jerome‐Majewska, Rima Rozen Tags: Original Research Article Source Type: research

Folate receptor autoantibodies in pregnancy related complications
ConclusionThis long‐term follow up of a subject with folate receptor autoantibodies is a first report of its kind and describes treatment strategy to prevent pregnancy related complications due to folate receptor autoantibodies. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 21, 2015 Category: Perinatology & Neonatology Authors: Iuliana Shapira, Jeffrey M. Sequeira, Edward V. Quadros Tags: Brief Report Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 9, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research