Birth Defects Research Part A: Clinical and Molecular Teratology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Editorial reflections on the etiology of structural birth defects: Established teratogens and risk factors
ConclusionThere are numerous risk factors, some modifiable, that have been proposed in recent years. These factors (associations) are only at the preliminary level in the causal chain and require replication. There is a need for more work on protective factors. The phenotypic characterization of cases with congenital defects has improved remarkably in recent years. However, there remains considerable concern with the precise characterization of exposures and the documentation of timing during embryologic development. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 20, 2015 Category: Perinatology & Neonatology Authors: Marcia L. Feldkamp, Lorenzo D. Botto, John C. Carey Tags: Editorial Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 11, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Editorial perspectives from the founding CDC leadership of the National Birth Defects Prevention study
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 10, 2015 Category: Perinatology & Neonatology Authors: Cynthia A. Moore, Paula W. Yoon, Larry D. Edmonds, J. David Erickson Tags: Editorial Source Type: research

Thalidomide embryopathy: Follow‐up of cases born between 1959 and 2010
ConclusionAlthough there is no sufficient evidence that thalidomide exposure caused or worsened the described events, this approach helps to better understand the TE phenotype, improves the clinical diagnosis, and can lead to adequate health support for these individuals. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 4, 2015 Category: Perinatology & Neonatology Authors: Thayne Woycinck Kowalski, Maria Teresa Vieira Sanseverino, Lavinia Schuler‐Faccini, Fernanda Sales Luiz Vianna Tags: Original Research Article Source Type: research

Hyperbole as Harmful as Cocaine
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Qwynten Richards, Carl L. Hart Tags: Correspondence Source Type: research

Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the national birth defects prevention study
ConclusionOur findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Jacqueline L. O'Brien, Peter H. Langlois, Christina C. Lawson, Angela Scheuerle, Carissa M. Rocheleau, Martha A. Waters, Elaine Symanski, Paul A. Romitti, A.J. Agopian, Philip J. Lupo, Tags: Brief Report Source Type: research

Multicenter investigation of lifestyle‐related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age
ConclusionSubjects with TE have also a risk for lifestyle‐related disease as well as the general Japanese population. In addition, cervical spine radiography and magnetic resonance imaging are recommended to assess block vertebrae in subjects with TE with gallbladder aplasia who develop shoulder pain. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Tomoko Shiga, Takuro Shimbo, Atsuto Yoshizawa Tags: Original Article Source Type: research

Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use
ConclusionOur study provides evidence that maternal and infant polymorphisms within the ERCC1, PARP2, ERCC5, and OSGEP genes are associated with CHD risk in the presence of maternal tobacco use. These results may provide insight into the susceptibility of having a pregnancy affected by CHDs among women who smoke. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Xinyu Tang, Charlotte A. Hobbs, Mario A. Cleves, Stephen W. Erickson, Stewart L. MacLeod, Sadia Malik, Tags: Original Research Article Source Type: research

Clinical aspects of Fanconi anemia individuals with the same mutation of FANCF identified by next generation sequencing
ConclusionThe systematic use of next generation sequencing will allow the recognition of individuals from rare complementation groups, a better definition of their clinical phenotypes, and consequently, an appropriate genetic counseling. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Elena Nicchia, Francesco Benedicenti, Daniela De Rocco, Chiara Greco, Roberta Bottega, Francesca Inzana, Michela Faleschini, Serena Bonin, Enrico Cappelli, Massimo Mogni, Franco Stanzial, Johanna Svahn, Carlo Dufour, Anna Savoia Tags: Original Research Article Source Type: research

Maternal occupational pesticide exposure and risk of congenital heart defects in the national birth defects prevention study
CONCLUSIONBroad pesticide exposure categories were not associated with CHDs overall, but examining specific CHD subtypes revealed some increased odds ratios. These results highlight the importance of examining specific CHDs separately. Because of multiple comparisons, additional work is needed to verify these associations. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Carissa M. Rocheleau, Stephen J. Bertke, Christina C. Lawson, Paul A. Romitti, Wayne T. Sanderson, Sadia Malik, Philip J. Lupo, Tania A. Desrosiers, Erin Bell, Charlotte Druschel, Adolfo Correa, Jennita Reefhuis, Tags: Original Research Article Source Type: research

Prenatal diagnosis of the VACTERL association using routine ultrasound examination
ConclusionFurther studies of fetuses with the VACTERL association are necessary to better delineate the malformations spectrum observed prenatally to improve the early recognition of the VACTERL association. Birth Defects Research (Part A), 2014. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Anne Debost‐Legrand, Carole Goumy, Hélène Laurichesse‐Delmas, Pierre Déchelotte, Isabelle Perthus, Christine Francannet, Didier Lémery, Denis Gallot Tags: Original Article Source Type: research

Poor sleep during the periconceptional period increases risk for neural tube defects in offspring
ConclusionMaternal frequent poor sleep during the periconceptional period may increase the risk for all NTDs and spina bifida. The association appears to be independent of some lifestyle factors that are closely associated with sleep quality. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 1, 2015 Category: Perinatology & Neonatology Authors: Zhiwen Li, Le Zhang, Lei Jin, Rongwei Ye, Camille Raynes‐Greenow, Aiguo Ren Tags: Original Research Article Source Type: research

Heme oxygenase‐1 promoter polymorphisms and risk of spina bifida
Conclusion: Although, an association was not found between HO‐1 polymorphisms and risk of spina bifida, we speculate that the combined effect of low HO‐1 expression and exposures to known environmental oxidative stressors (low folate status or diabetes), may overwhelm antioxidant defenses and increase risk of NTDs and warrants further study. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 1, 2015 Category: Perinatology & Neonatology Authors: Kazumichi Fujioka, Wei Yang, Matthew B. Wallenstein, Hui Zhao, Ronald J. Wong, David K. Stevenson, Gary M. Shaw Tags: Original Research Article Source Type: research

Register based study of anorectal anomalies over 26 years: Associated anomalies, prevalence, and trends
CONCLUSIONThe prevalence of anorectal anomalies in this study is comparable to other case series. There was no evidence of a temporal increase in prevalence. We confirmed a male predominance of anorectal anomalies and no significant association with maternal age. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 1, 2015 Category: Perinatology & Neonatology Authors: Alok S. Godse, Kate E. Best, Anne Lawson, Lucy Rosby, Judith Rankin Tags: Research Article Source Type: research

Promise and peril: Dissemination of findings from studies of drugs used in pregnancy and their association with birth defects
ConclusionRigorous research evaluating the impact of drugs used in pregnancy, coupled with effective dissemination strategies, has the potential improve outcomes for mothers and their infants for generations. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 1, 2015 Category: Perinatology & Neonatology Authors: Stephen W. Patrick, William O. Cooper Tags: Brief Report Source Type: research