Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use

ConclusionOur study provides evidence that maternal and infant polymorphisms within the ERCC1, PARP2, ERCC5, and OSGEP genes are associated with CHD risk in the presence of maternal tobacco use. These results may provide insight into the susceptibility of having a pregnancy affected by CHDs among women who smoke. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 2, 2015 Category: Perinatology & Neonatology Authors: Xinyu Tang, Charlotte A. Hobbs, Mario A. Cleves, Stephen W. Erickson, Stewart L. MacLeod, Sadia Malik, Tags: Original Research Article Source Type: research