Heme oxygenase‐1 promoter polymorphisms and risk of spina bifida

Conclusion: Although, an association was not found between HO‐1 polymorphisms and risk of spina bifida, we speculate that the combined effect of low HO‐1 expression and exposures to known environmental oxidative stressors (low folate status or diabetes), may overwhelm antioxidant defenses and increase risk of NTDs and warrants further study. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc.
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - Category: Perinatology & Neonatology Authors: Tags: Original Research Article Source Type: research