Birth Defects Research Part A: Clinical and Molecular Teratology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preventing birth defects: The value of the NBDPS case–control approach
Birth Defect Registries provide a basis for epidemiological research into risk factors, thus facilitating a growing understanding of what causes congenital anomalies and how one might target preventive public health actions and reduce inequalities. The National Birth Defects Prevention Study (NBDPS) has used 10 U.S. registries as a basis for a large case–control study. This commentary reviews its methodology and selected areas of output. The strengths of NBDPS lie in the quality of diagnostic coding and classification of birth defects and its size. The sources of bias in NBDPS data relate particularly to retrospective ex...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Helen Dolk Tags: Original Research Article Source Type: research

Sensory neuron differentiation potential of in utero mesenchymal stem cell transplantation in rat fetuses with spina bifida aperta
CONCLUSIONOur results indicate that the transplantation of MSCs into the spinal cord could promote the transplanted MSCs and the surrounding cells to differentiate toward a sensory neuron cell fate and to play an important role in protecting sensory neurons in DRG. This approach might be of value in the treatment of sensory neuron deficiency in spina bifida aperta. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Wei Ma, Xiaowei Wei, Hui Gu, Hui Li, Kaoping Guan, Dan Liu, Lizhu Chen, Songying Cao, Dong An, Henan Zhang, Tianchu Huang, Jianing Miao, Guifeng Zhao, Di Wu, Bo Liu, Weilin Wang, Zhengwei Yuan Tags: Original Research Article Source Type: research

What we don't know can hurt us: Nonresponse bias assessment in birth defects research
CONCLUSIONAs survey response rates continue to decline, the importance of assessing the potential impact of nonresponse bias has become more critical. Birth defects research is particularly conducive to nonresponse bias analysis, especially when birth defect registries and birth certificate records are used. Future birth defect studies which use population‐based surveillance data and have incomplete participation could benefit from this type of nonresponse bias assessment. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Paula D. Strassle, Cynthia H. Cassell, Stuart K. Shapira, Sarah C. Tinker, Robert E. Meyer, Scott D. Grosse Tags: Original Article Source Type: research

Erratum to maternal prepregnancy body mass index and risk of neural tube defects: A population‐based case–control study in shanxi province, China
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Zhiwen Li, Jianmeng Liu, Rongwei Ye, Le Zhang, Lijun Pei, Xiaoying Zheng, Aiguo Ren Tags: Erratum Source Type: research

In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model
ConclusionWe conclude that nicotine exposure is associated with epigenetic alterations in the offspring and may lead to susceptibility to adult disease,. Our finding that in utero exposure to nicotine is associated with inhibition of histone deacetylase activity in the brain of offspring is of importance as a similar inhibition has been suggested as a mechanism for the potentiation of addiction. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Melissa A. Suter, Adi R. Abramovici, Emily Griffin, D. Ware Branch, Robert H. Lane, Joan Mastrobattista, Virender K. Rehan, Kjersti Aagaard Tags: Original Research Article Source Type: research

CMV‐induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition
ConclusionThis phenomenon has important biologic and therapeutic implications. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Michael Melnick, Tina Jaskoll Tags: Research Article Source Type: research

Preventable spina bifida and anencephaly in Europe
CONCLUSIONEurope has an epidemic of spina bifida and anencephaly compared with countries with mandatory folic acid fortification policy. Primary prevention through mandatory folic acid fortification would considerably reduce the number of affected pregnancies, and associated additional costs. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Rima Obeid, Klaus Pietrzik, Godfrey P. Oakley, Vijaya Kancherla, Wolfgang Holzgreve, Simon Wieser Tags: Original Research Article Source Type: research

Application of data screening to drug exposure in large risk factor studies of birth defects
ConclusionWhile screening programs such as the one described can be a valuable tool for exploring potential associations in large data bases, they must be applied with caution. The issue of multiple testing and chance findings is a major concern. While statistics are a necessary component, human judgment must be an integral part of the process. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Carol Louik, Martha Werler, Marlene Anderka, Allen A. Mitchell Tags: Original Research Article Source Type: research

Issues involved in the phenotypic classification of orofacial clefts ascertained through a state birth defects registry for the north carolina cleft outcomes study
Conclusion: Verbatim descriptions of the clinical findings are critical for accurate classification of diagnoses. This review process improved the precision of orofacial cleft phenotype classification for our study. Precision would have been further improved if all of the cases had verbatim descriptions of diagnoses and all medical records could have been reviewed by the classification team. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Arthur S. Aylsworth, Alexander C. Allori, Luiz A. Pimenta, Jeffrey R. Marcus, Katherine G. Harmsen, Stephanie E. Watkins, Barry L. Ramsey, Ronald P. Strauss, Robert E. Meyer Tags: Original Research Article Source Type: research

Descriptive epidemiology of birth defects thought to arise by new mutation
ConclusionThis study suggests that birth defects arising by new mutation may be more prevalent among offspring of older parents and in plural births. The increasing time pattern and race/ethnic pattern may be related to greater use of or access to genetic tests. This approach to mutation epidemiology seems feasible for birth defects registries to consider.Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Peter H. Langlois, Angela E. Scheuerle Tags: Original Research Article Source Type: research

Evaluating cost and resource use associated with pulse oximetry screening for critical congenital heart disease: Empiric estimates and sources of variation
ConclusionCCHD screening by means of pulse oximetry is reasonably fast for most babies, leading to relative small labor costs with little variation by provider type. The main driver of costs is equipment: in a high throughput setting, reusable probes are currently associated with considerable cost saving compared with disposable probes. As programs expand to universal screening, improved and cheaper technologies could lead to considerable economies of scale. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Matthew R. Reeder, Jaewhan Kim, Amy Nance, Sergey Krikov, Marcia L. Feldkamp, Harper Randall, Lorenzo D. Botto Tags: Original Research Article Source Type: research

Assessing congenital malformation risk from medications used in pregnancy: The contribution of NBDPS in pregnancy labeling of prescription drug products
ConclusionThe Pregnancy and Lactation Labeling Rule will set new and improved standards for the inclusion of information about the use of prescription drugs and biological products during pregnancy; the National Birth Defects Prevention Study, along with other data sources, will be critical for providing safety data to inform product labeling. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Melissa S. Tassinari, Leyla Sahin, Lynne P. Yao Tags: Brief Report Source Type: research

Tea consumption is not associated with reduced plasma folate concentration among chinese pregnant women
ConclusionLow level of tea drinking is not associated with decreased plasma folate concentration in the Chinese populations with high and low prevalence of NTDs. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 27, 2015 Category: Perinatology & Neonatology Authors: Jufen Liu, Lei Jin, Yali Zhang, Le Zhang, Zhiwen Li, Linlin Wang, Rongwei Ye, Aiguo Ren Tags: Original Research Source Type: research

Maternal periconceptional alcohol consumption and congenital heart defects
ConclusionAnalysis of this large, well‐defined study sample did not show statistically significant increased risks between measures of maternal alcohol consumption and most CHDs examined. These findings may reflect, in part, limitations with retrospective exposure assessment or unmeasured confounders. Additional studies with continued improvement in measurement of alcohol consumption are recommended. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 27, 2015 Category: Perinatology & Neonatology Authors: Yong Zhu, Paul A. Romitti, Kristin M. Caspers Conway, Dereck H. Shen, Lixian Sun, Marilyn L. Browne, Lorenzo D. Botto, Angela E. Lin, Charlotte M. Druschel, Tags: Original Research Article Source Type: research

Reflections on the etiology of structural birth defects: Established teratogens and risk factors
ConclusionThere are numerous risk factors, some modifiable, that have been proposed in recent years. These factors (associations) are only at the preliminary level in the causal chain and require replication. There is a need for more work on protective factors. The phenotypic characterization of cases with congenital defects has improved remarkably in recent years. However, there remains considerable concern with the precise characterization of exposures and the documentation of timing during embryologic development. Birth Defects Research (Part A) 103:652–655, 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 20, 2015 Category: Perinatology & Neonatology Authors: Marcia L. Feldkamp, Lorenzo D. Botto, John C. Carey Tags: Editorial Source Type: research