In utero nicotine exposure epigenetically alters fetal chromatin structure and differentially regulates transcription of the glucocorticoid receptor in a rat model

ConclusionWe conclude that nicotine exposure is associated with epigenetic alterations in the offspring and may lead to susceptibility to adult disease,. Our finding that in utero exposure to nicotine is associated with inhibition of histone deacetylase activity in the brain of offspring is of importance as a similar inhibition has been suggested as a mechanism for the potentiation of addiction. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2015 Category: Perinatology & Neonatology Authors: Melissa A. Suter, Adi R. Abramovici, Emily Griffin, D. Ware Branch, Robert H. Lane, Joan Mastrobattista, Virender K. Rehan, Kjersti Aagaard Tags: Original Research Article Source Type: research